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    ACR4 ACT domain repeat 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843236, updated on 14-Nov-2024

    Summary

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    Official Symbol
    ACR4
    Official Full Name
    ACT domain repeat 4
    Primary source
    TAIR:AT1G69040
    Locus tag
    AT1G69040
    See related
    Araport:AT1G69040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ACT domain repeat 4; F4N2.2; F4N2_2
    Summary
    ACT-domain containing protein involved in feedback regulation of amino acid metabolism
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    Genomic context

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    See ACR4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (25957567..25960401)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene BSD domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Chaperone DnaJ-domain superfamily protein Neighboring gene nucleolar-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization and enzymatic properties of protein kinase ACR4 from Arabidopsis thaliana. Zhao Y, et al. Biochem Biophys Res Commun, 2017 Jul 22. PMID 28571742
    2. PP2A-3 interacts with ACR4 and regulates formative cell division in the Arabidopsis root. Yue K, et al. Proc Natl Acad Sci U S A, 2016 Feb 2. PMID 26792519, Free PMC Article
    3. Epidermal identity is maintained by cell-cell communication via a universally active feedback loop in Arabidopsis thaliana. San-Bento R, et al. Plant J, 2014 Jan. PMID 24147836
    4. Moderation of Arabidopsis root stemness by CLAVATA1 and ARABIDOPSIS CRINKLY4 receptor kinase complexes. Stahl Y, et al. Curr Biol, 2013 Mar 4. PMID 23394827
    5. Evidence for intermolecular interactions between the intracellular domains of the arabidopsis receptor-like kinase ACR4, its homologs and the Wox5 transcription factor. Meyer MR, et al. PLoS One, 2015. PMID 25756623, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. It reports the purification and enzymatic properties of the intracellular kinase domain (residues 464-799) of ACR4 (ACR4(IKD)), and study may lay the foundation for structure determination of ACR4(IKD) and further functional research, for example, screening significant substrates of ACR4 in Arabidopsis thaliana.
      Title: Characterization and enzymatic properties of protein kinase ACR4 from Arabidopsis thaliana.
    2. Results show that ACR4 can phosphorylate its homologs and interact with all four of them in the unphosphorylated state. Also, ACR4 can phosphorylate WOX5 and four phosphorylation sites within the WOX5 protein sequence have been identified.
      Title: Evidence for intermolecular interactions between the intracellular domains of the arabidopsis receptor-like kinase ACR4, its homologs and the Wox5 transcription factor.
    3. ACR4 positively affects the expression of ATML1 and PDF2 in seedlings. In contrast, ATML1- and PDF2-containing complexes directly and negatively affect both their own expression and that of ACR4.
      Title: Epidermal identity is maintained by cell-cell communication via a universally active feedback loop in Arabidopsis thaliana.
    4. interaction of CLV1 with ACR4 serves to moderate and control stemness homeostasis in the root meristem
      Title: Moderation of Arabidopsis root stemness by CLAVATA1 and ARABIDOPSIS CRINKLY4 receptor kinase complexes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_105575.3
    NM_202378.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of amino acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cytokinin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasmodesma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ACT domain repeat 4
    NP_177067.1
    • ACT domain repeat 4 (ACR4); FUNCTIONS IN: amino acid binding; INVOLVED IN: regulation of cellular amino acid metabolic process, response to cytokinin stimulus; LOCATED IN: cytosol; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Amino acid-binding ACT (InterPro:IPR002912); BEST Arabidopsis thaliana protein match is: ACT domain repeat 5 (TAIR:AT2G03730.2); Has 2469 Blast hits to 1537 proteins in 400 species: Archae - 0; Bacteria - 1346; Metazoa - 0; Fungi - 0; Plants - 646; Viruses - 0; Other Eukaryotes - 477 (source: NCBI BLink).
    NP_974107.1
    • ACT domain repeat 4 (ACR4); FUNCTIONS IN: amino acid binding; INVOLVED IN: regulation of cellular amino acid metabolic process, response to cytokinin stimulus; LOCATED IN: cytosol; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Amino acid-binding ACT (InterPro:IPR002912); BEST Arabidopsis thaliana protein match is: ACT domain repeat 5 (TAIR:AT2G03730.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      25957567..25960401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_202378.2 → NP_974107.1  ACT domain repeat 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974107.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WQR5, F4I0I7
      Conserved Domains (3) summary
      cd04895
      Location:37 → 108
      ACT_ACR_1; ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein)
      cd04897
      Location:261 → 335
      ACT_ACR_3; ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein)
      cl09141
      Location:339 → 410
      ACT; ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme

    2. NM_105575.3 → NP_177067.1  ACT domain repeat 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177067.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GWT8, Q8LJW3, Q9LQB5
      UniProtKB/TrEMBL
      A0A178WD79
      Conserved Domains (3) summary
      cd04895
      Location:33 → 104
      ACT_ACR_1; ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein)
      cd04897
      Location:257 → 331
      ACT_ACR_3; ACT domain-containing protein which is composed almost entirely of four ACT domain repeats (the "ACR" protein)
      cl09141
      Location:335 → 406
      ACT; ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LJW3.1

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