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    PMSR2 peptidemethionine sulfoxide reductase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830637, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PMSR2
    Official Full Name
    peptidemethionine sulfoxide reductase 2
    Primary source
    TAIR:AT5G07460
    Locus tag
    AT5G07460
    See related
    Araport:AT5G07460
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA METHIONINE SULFOXIDE REDUCTASE 2; ATMSRA2; peptidemethionine sulfoxide reductase 2; T2I1.170; T2I1_170
    Summary
    ubiquitous enzyme that repairs oxidatively damaged proteins. Methionine sulfoxide reductase activity. Mutant lacking reductase activity showed increased protein oxidation, nitration and glycation of specific amino acid residues during darkness.
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    Genomic context

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    See PMSR2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (2360630..2362228, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene glutamate dehydrogenase 2 Neighboring gene cyclin p4;3 Neighboring gene peptidemethionine sulfoxide reductase 3 Neighboring gene Cupredoxin superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantitative measurement of specific biomarkers for protein oxidation, nitration and glycation in Arabidopsis leaves. Bechtold U, et al. Plant J, 2009 Aug. PMID 19392687
    2. Arabidopsis peptide methionine sulfoxide reductase2 prevents cellular oxidative damage in long nights. Bechtold U, et al. Plant Cell, 2004 Apr. PMID 15031406, Free PMC Article
    3. Plant methionine sulfoxide reductase A and B multigenic families. Rouhier N, et al. Photosynth Res, 2006 Sep. PMID 17031545
    4. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_120828.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-methionine:thioredoxin-disulfide S-oxidoreductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables peptide-methionine (S)-S-oxide reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    peptidemethionine sulfoxide reductase 2
    NP_196363.1
    • peptidemethionine sulfoxide reductase 2 (PMSR2); CONTAINS InterPro DOMAIN/s: Peptide methionine sulphoxide reductase MsrA (InterPro:IPR002569); BEST Arabidopsis thaliana protein match is: peptidemethionine sulfoxide reductase 3 (TAIR:AT5G07470.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      2360630..2362228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120828.4 → NP_196363.1  peptidemethionine sulfoxide reductase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196363.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LY15
      UniProtKB/TrEMBL
      A0A178UBC0, A0A5S9Y4E8
      Conserved Domains (1) summary
      pfam01625
      Location:56 → 196
      PMSR; Peptide methionine sulfoxide reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LY15.1

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