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    HTB2 histone B2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832352, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HTB2
    Official Full Name
    histone B2
    Primary source
    TAIR:AT5G22880
    Locus tag
    AT5G22880
    See related
    Araport:AT5G22880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    H2B; histone B2; HISTONE H2B; MRN17.11; MRN17_11
    Summary
    Encodes a histone 2B (H2B) protein. This protein can be ubiquitinated in planta, and this modification depends on the HUB1 and HUB2 E3 ubiquitin ligases.
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    Genomic context

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    See HTB2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    1
    Sequence:
    Chromosome: 5; NC_003076.8 (7651868..7652714, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family Neighboring gene uncharacterized protein Neighboring gene C2H2 and C2HC zinc fingers superfamily protein Neighboring gene cation/H+ exchanger 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Function of histone H2B monoubiquitination in transcriptional regulation of auxin biosynthesis in Arabidopsis. Zhang L, et al. Commun Biol, 2021 Feb 15. PMID 33589721, Free PMC Article
    2. Histone H2B monoubiquitination is involved in regulating the dynamics of microtubules during the defense response to Verticillium dahliae toxins in Arabidopsis. Hu M, et al. Plant Physiol, 2014 Apr. PMID 24567190, Free PMC Article
    3. Histone H2B deubiquitination is required for transcriptional activation of FLOWERING LOCUS C and for proper control of flowering in Arabidopsis. Schmitz RJ, et al. Plant Physiol, 2009 Feb. PMID 19091875, Free PMC Article
    4. DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis. Nassrallah A, et al. Elife, 2018 Sep 7. PMID 30192741, Free PMC Article
    5. Monoubiquitination of histone 2B at the disease resistance gene locus regulates its expression and impacts immune responses in Arabidopsis. Zou B, et al. Plant Physiol, 2014 May. PMID 24664204, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Function of histone H2B monoubiquitination in transcriptional regulation of auxin biosynthesis in Arabidopsis.
      Title: Function of histone H2B monoubiquitination in transcriptional regulation of auxin biosynthesis in Arabidopsis.
    2. DET1-DDB1-Associated-1 (DDA1) protein interacts with SGF11 in vivo, linking the DET1 complex to light-dependent ubiquitin-mediated proteolytic degradation of the deubiquitination module.
      Title: DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis.
    3. H2B monoubiquitination at the R gene locus regulates its expression.
      Title: Monoubiquitination of histone 2B at the disease resistance gene locus regulates its expression and impacts immune responses in Arabidopsis.
    4. These findings provide direct evidence for H2B monoubiquitination as an important modification with regulatory roles in the defense against Verticillium dahliae toxins.
      Title: Histone H2B monoubiquitination is involved in regulating the dynamics of microtubules during the defense response to Verticillium dahliae toxins in Arabidopsis.
    5. Role of histone H2B deubiquitination in the activation of gene expression and the perturbation of histone H2B deubiquitination in the timing of the floral transition in Arabidopsis.
      Title: Histone H2B deubiquitination is required for transcriptional activation of FLOWERING LOCUS C and for proper control of flowering in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_122194.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    histone B2
    NP_197679.1
    • histone B2 (HTB2); FUNCTIONS IN: DNA binding; INVOLVED IN: nucleosome assembly; LOCATED IN: nucleolus, nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Histone H2B (InterPro:IPR000558), Histone-fold (InterPro:IPR009072), Histone core (InterPro:IPR007125); BEST Arabidopsis thaliana protein match is: Histone superfamily protein (TAIR:AT3G45980.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      7651868..7652714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122194.3 → NP_197679.1  histone B2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197679.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q96516, Q9FFC0
      UniProtKB/TrEMBL
      A0A178UDD3, A0A654G3H0, Q1H5F7
      Conserved Domains (1) summary
      smart00427
      Location:54 → 144
      H2B; Histone H2B
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FFC0.3

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