AFB2 auxin signaling F-box 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: AFB2
Official Full Name: auxin signaling F-box 2
Primary source: TAIR:AT3G26810
Locus tag: AT3G26810
See related: Araport:AT3G26810
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: auxin signaling F-box 2
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Genomic context

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See AFB2 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 3

Sequence:: Chromosome: 3; NC_003074.8 (9867652..9870782)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FERONIA-mediated TIR1/AFB2 oxidation stimulates auxin signaling in Arabidopsis.
Title: FERONIA-mediated TIR1/AFB2 oxidation stimulates auxin signaling in Arabidopsis.
Control of Adventitious Rooting by TIR1/AFB2-Aux/IAA-Dependent Auxin Signaling in Arabidopsis
Title: A Molecular Framework for the Control of Adventitious Rooting by TIR1/AFB2-Aux/IAA-Dependent Auxin Signaling in Arabidopsis.
Auxin signaling through TIR1/AFB2/AFB3 mediates feedback regulation of indole-3-acetic acid biosynthesis.
Title: Auxin signaling through SCF(TIR1/AFBs) mediates feedback regulation of IAA biosynthesis.
Results suggest the MIRNA393a and MIRNA393b -mediated regulation of TIR1 and AFB2 during embryogenic transition.
Title: miR393 contributes to the embryogenic transition induced in vitro in Arabidopsis via the modification of the tissue sensitivity to auxin treatment.
miR393 regulation of the TIR1 and AFB2 receptors could be a critical checkpoint between auxin signaling and specfic redox-associated components
Title: MiR393 regulation of auxin signaling and redox-related components during acclimation to salinity in Arabidopsis.
miR393 and secondary siRNAs regulate expression of the AFB2
Title: miR393 and secondary siRNAs regulate expression of the TIR1/AFB2 auxin receptor clade and auxin-related development of Arabidopsis leaves.
It is reported that salicylic acid (SA)-treated tir1 afb2 mutant shows enhanced transcript level of a pathogenesis related gene, PR1.
Title: Auxin and salicylic acid signalings counteract the regulation of adaptive responses to stress.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_113593.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables auxin binding	IGI Inferred from Genetic Interaction more info	PubMed
enables auxin binding	ISS Inferred from Sequence or Structural Similarity more info
enables inositol hexakisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within auxin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in auxin-activated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within pollen maturation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within stamen development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in plant-type vacuole	HDA more info	PubMed

General protein information

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Preferred Names: auxin signaling F-box 2

NP_566800.1

auxin signaling F-box 2 (AFB2); FUNCTIONS IN: ubiquitin-protein ligase activity, auxin binding; INVOLVED IN: stamen development, pollen maturation, response to molecule of bacterial origin; LOCATED IN: plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: F-box domain, cyclin-like (InterPro:IPR001810); BEST Arabidopsis thaliana protein match is: auxin signaling F-box 3 (TAIR:AT1G12820.1); Has 2856 Blast hits to 1854 proteins in 175 species: Archae - 0; Bacteria - 10; Metazoa - 953; Fungi - 156; Plants - 1568; Viruses - 0; Other Eukaryotes - 169 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

9867652..9870782

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_113593.3 → NP_566800.1 auxin signaling F-box 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_566800.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LW29

UniProtKB/TrEMBL

A0A178VGF7, A0A5S9XG37

Conserved Domains (4) summary

cd09293
Location:304 → 393

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:286 → 311

LRR_AMN1; leucine-rich repeat [structural motif]

pfam18511
Location:1 → 42

F-box_5

pfam18791
Location:61 → 107

Transp_inhibit; Transport inhibitor response 1 protein domain