VDAC1 voltage dependent anion channel 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: VDAC1
Official Full Name: voltage dependent anion channel 1
Primary source: TAIR:AT3G01280
Locus tag: AT3G01280
See related: Araport:AT3G01280
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: 5076; ARABIDOPSIS THALIANA VOLTAGE DEPENDENT ANION CHANNEL 1; ATVDAC1; T22N4.9; T22N4_9; voltage dependent anion channel 1
Summary: Encodes a voltage-dependent anion channel (VDAC: AT3G01280/VDAC1, AT5G67500/VDAC2, AT5G15090/VDAC3, AT5G57490/VDAC4, AT5G15090/VDAC5). VDACs are reported to be porin-type, beta-barrel diffusion pores. They are prominently localized in the outer mitochondrial membrane and are involved in metabolite exchange between the organelle and the cytosol.
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Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Abnormal ovules in the process of female gametogenesis were observed. Both mitochondrial transmembrane potential and ATP synthesis rate were obviously reduced in the mitochondria isolated from atvdac1 plants.
Title: Arabidopsis voltage-dependent anion channel 1 (AtVDAC1) is required for female development and maintenance of mitochondrial functions related to energy-transaction.
Data indicate that both voltage-dependent anion channel 1 (AtVDAC1) and calcium sensor CBL1 regulate cold stress responses during seed germination and plant development.
Title: The voltage-dependent anion channel 1 (AtVDAC1) negatively regulates plant cold responses during germination and seedling development in Arabidopsis and interacts with calcium sensor CBL1.
AtVDAC1 has a main function in mitochondria
Title: Voltage-dependent-anion-channels (VDACs) in Arabidopsis have a dual localization in the cell but show a distinct role in mitochondria.
VDAC1 is not only necessary for normal growth but also important for disease resistance through regulation of hydrogen peroxide generation.
Title: Molecular and genetic characterization of the gene family encoding the voltage-dependent anion channel in Arabidopsis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_110994.4

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated monoatomic anion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
NOT located_in Golgi apparatus	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in chloroplast	HDA more info	PubMed
NOT located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast envelope	HDA more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in plant-type vacuole	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in vacuole	HDA more info	PubMed

NP_186777.1

voltage dependent anion channel 1 (VDAC1); FUNCTIONS IN: voltage-gated anion channel activity; INVOLVED IN: response to bacterium, anion transport; LOCATED IN: in 7 components; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: Porin, eukaryotic type (InterPro:IPR001925); BEST Arabidopsis thaliana protein match is: voltage dependent anion channel 3 (TAIR:AT5G15090.2); Has 888 Blast hits to 888 proteins in 197 species: Archae - 0; Bacteria - 0; Metazoa - 413; Fungi - 146; Plants - 300; Viruses - 0; Other Eukaryotes - 29 (source: NCBI BLink).