CSD2 copper/zinc superoxide dismutase 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: CSD2
Official Full Name: copper/zinc superoxide dismutase 2
Primary source: TAIR:AT2G28190
Locus tag: AT2G28190
See related: Araport:AT2G28190
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtSOD2; COPPER/ZINC SUPEROXIDE DISMUTASE; copper/zinc superoxide dismutase 2; COPPER/ZINC SUPEROXIDE DISMUTASE 2; CZSOD2; F24D13.2; F24D13_2; SOD2; superoxide dismutase 2
Summary: Encodes a chloroplastic copper/zinc superoxide dismutase CSD2 that can detoxify superoxide radicals. Its expression is affected by miR398-directed mRNA cleavage. Activation depends totally on CCS. Overexpression of a miR398-resistant form of CSD2 leads to more dramatic improvements in stress (hight light, Cu2+ and methyl viologen) tolerance than overexpression of wild-type CSD2.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See CSD2 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 8

Sequence:: Chromosome: 2; NC_003071.7 (12014412..12016569)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In a series of grafting experiments using spl7 mutant and wild-type (WT) plants, expression of Cu-responsive microRNAs and the resulting suppression of CSD1 and CSD2 mRNAs were observed in leaves only when the aerial part was from WT plants, in which a low level of SPL7 was transcribed also in the vascular tissues.
Title: SPL7 locally regulates copper-homeostasis-related genes in Arabidopsis.
downregulation of CSD2 by the heat-inducible miR398 is required for thermotolerance in Arabidopsis.
Title: Downregulation of CSD2 by a heat-inducible miR398 is required for thermotolerance in Arabidopsis.
Data indicate that in the MKK5-RNAi (RNA interference) lines, the induction of CSD1 and CSD2 as well as the activation of MKK5 activity were completely arrested.
Title: MKK5 regulates high light-induced gene expression of Cu/Zn superoxide dismutase 1 and 2 in Arabidopsis.
Data indicate that transgenic plants expressing miR398-resistant forms of CSD1, CSD2 and CCS under the control of their native promoters are more sensitive to heat stress.
Title: Heat stress induction of miR398 triggers a regulatory loop that is critical for thermotolerance in Arabidopsis.
miR398 links expression of the three major chloroplast copper proteins, plastocyanin, CCS1 and Csd2, to copper availability.
Title: The strength of the miR398-Csd2-CCS1 regulon is subject to natural variation in Arabidopsis thaliana.
Results show that CSD1, but not CSD2, mRNA levels were negatively correlated with miR398 levels during ozone, salinity and biotic stress.
Title: Biotic and abiotic stress down-regulate miR398 expression in Arabidopsis.
CSD2 expression is fine-tuned by miR398-directed mRNA cleavage.
Title: Posttranscriptional induction of two Cu/Zn superoxide dismutase genes in Arabidopsis is mediated by downregulation of miR398 and important for oxidative stress tolerance.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_128379.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables superoxide dismutase activity	IDA Inferred from Direct Assay more info	PubMed
enables superoxide dismutase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to UV-B	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to light intensity	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to ozone	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to salt stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to sucrose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within removal of superoxide radicals	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within response to copper ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to iron ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in response to salt stress	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in apoplast	HDA more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast stroma	HDA more info	PubMed
located_in thylakoid	HDA more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: copper/zinc superoxide dismutase 2

NP_565666.1

copper/zinc superoxide dismutase 2 (CSD2); FUNCTIONS IN: superoxide dismutase activity; INVOLVED IN: in 6 processes; LOCATED IN: thylakoid, apoplast, chloroplast stroma, chloroplast; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Superoxide dismutase, copper/zinc, binding site (InterPro:IPR018152), Superoxide dismutase, copper/zinc binding (InterPro:IPR001424); BEST Arabidopsis thaliana protein match is: copper/zinc superoxide dismutase 1 (TAIR:AT1G08830.2); Has 4720 Blast hits to 4704 proteins in 1488 species: Archae - 6; Bacteria - 1989; Metazoa - 1257; Fungi - 323; Plants - 669; Viruses - 141; Other Eukaryotes - 335 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

12014412..12016569

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_128379.4 → NP_565666.1 copper/zinc superoxide dismutase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_565666.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O78310, Q0WUQ0, Q541D5, Q9SUJ7, Q9SUJ8

UniProtKB/TrEMBL

A0A178VRV1, A0A5S9X1Z4, A0A7G2ECD5

Conserved Domains (1) summary

cl00891
Location:66 → 213

Cu-Zn_Superoxide_Dismutase; Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...