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    TIP TCV-interacting protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832530, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TIP
    Official Full Name
    TCV-interacting protein
    Primary source
    TAIR:AT5G24590
    Locus tag
    AT5G24590
    See related
    Araport:AT5G24590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ANAC091; Arabidopsis NAC domain containing protein 91; TCV-interacting protein
    Summary
    Member of NAc protein family. Interacts with turnip crinkle virus (TCV) capsid protein. Transcription factor involved in regulating the defense response of Arabidopsis to TCV.
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    Genomic context

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    See TIP in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (8416375..8419076, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene TRP-like ion channel protein (Protein of unknown function, DUF599) Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HRT-mediated hypersensitive response and resistance to Turnip crinkle virus in Arabidopsis does not require the function of TIP, the presumed guardee protein. Jeong RD, et al. Mol Plant Microbe Interact, 2008 Oct. PMID 18785827
    2. HRT gene function requires interaction between a NAC protein and viral capsid protein to confer resistance to turnip crinkle virus. Ren T, et al. Plant Cell, 2000 Oct. PMID 11041886, Free PMC Article
    3. Turnip crinkle virus coat protein inhibits the basal immune response to virus invasion in Arabidopsis by binding to the NAC transcription factor TIP. Donze T, et al. Virology, 2014 Jan 20. PMID 24418554, Free PMC Article
    4. A nuclear factor regulates abscisic acid responses in Arabidopsis. Kim MJ, et al. Plant Physiol, 2009 Nov. PMID 19759343, Free PMC Article
    5. Type III effectors orchestrate a complex interplay between transcriptional networks to modify basal defence responses during pathogenesis and resistance. Truman W, et al. Plant J, 2006 Apr. PMID 16553893

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Turnip crinkle virus coat protein inhibits the basal immune response in Arabidopsis by binding to the TIP protein.
      Title: Turnip crinkle virus coat protein inhibits the basal immune response to virus invasion in Arabidopsis by binding to the NAC transcription factor TIP.
    2. Results show that loss of TIP does not alter HR or resistance to TCV, but resulted in increased replication of TCV and Cucumber mosaic virus, suggesting that TIP may play a role in basal resistance but is not required for HRT-mediated signaling.
      Title: HRT-mediated hypersensitive response and resistance to Turnip crinkle virus in Arabidopsis does not require the function of TIP, the presumed guardee protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_122367.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    acts_upstream_of_or_within defense response to virus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in positive regulation of defense response to virus by host IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to molecule of bacterial origin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to virus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in viral process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    TCV-interacting protein
    NP_197847.3
    • TCV-interacting protein (TIP); CONTAINS InterPro DOMAIN/s: No apical meristem (NAM) protein (InterPro:IPR003441); BEST Arabidopsis thaliana protein match is: NAC domain containing protein 62 (TAIR:AT3G49530.1); Has 2952 Blast hits to 2945 proteins in 75 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 2952; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      8416375..8419076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122367.4 → NP_197847.3  TCV-interacting protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197847.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LKG8
      UniProtKB/TrEMBL
      A0A178UKU0, A0A654G3R9
      Conserved Domains (1) summary
      pfam02365
      Location:14 → 140
      NAM; No apical meristem (NAM) protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LKG8.1

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