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    FMO GS-OX5 flavin-monooxygenase glucosinolate S-oxygenase 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837766, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FMO GS-OX5
    Official Full Name
    flavin-monooxygenase glucosinolate S-oxygenase 5
    Primary source
    TAIR:AT1G12140
    Locus tag
    AT1G12140
    See related
    Araport:AT1G12140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    flavin-monooxygenase glucosinolate S-oxygenase 5; T28K15.12; T28K15_12
    Summary
    belongs to the flavin-monooxygenase (FMO) family, encodes a glucosinolate S-oxygenase that catalyzes the conversion of methylthioalkyl glucosinolates to methylsulfinylalkyl glucosinolates
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    Genomic context

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    See FMO GS-OX5 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (4121285..4124595)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene hypothetical protein (DUF863) Neighboring gene Flavin-binding monooxygenase family protein Neighboring gene ncRNA Neighboring gene weak chloroplast movement under blue light protein (DUF827) Neighboring gene ncRNA Neighboring gene Flavin-binding monooxygenase family protein Neighboring gene F-box family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. flasher, a novel mutation in a glucosinolate modifying enzyme, conditions changes in plant architecture and hormone homeostasis. Garrido AN, et al. Plant J, 2020 Sep. PMID 32529723
    2. Identification of a flavin-monooxygenase as the S-oxygenating enzyme in aliphatic glucosinolate biosynthesis in Arabidopsis. Hansen BG, et al. Plant J, 2007 Jun. PMID 17461789
    3. Subclade of flavin-monooxygenases involved in aliphatic glucosinolate biosynthesis. Li J, et al. Plant Physiol, 2008 Nov. PMID 18799661, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. flasher, a novel mutation in a glucosinolate modifying enzyme, conditions changes in plant architecture and hormone homeostasis.
      Title: flasher, a novel mutation in a glucosinolate modifying enzyme, conditions changes in plant architecture and hormone homeostasis.
    2. Identification of FMOprovides a molecular tool for breeding of Brassica vegetable crops with increased levels of glucosinolates.
      Title: Identification of a flavin-monooxygenase as the S-oxygenating enzyme in aliphatic glucosinolate biosynthesis in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001084053.1
    NM_001332018.1
    NM_101086.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 8-methylthiopropyl glucosinolate S-oxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 8-methylthiopropyl glucosinolate S-oxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables N,N-dimethylaniline monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within floral organ morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within glucosinolate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of hormone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    flavin-monooxygenase glucosinolate S-oxygenase 5
    NP_001077522.1
    • flavin-monooxygenase glucosinolate S-oxygenase 5 (FMO GS-OX5); CONTAINS InterPro DOMAIN/s: Flavin-containing monooxygenase FMO (InterPro:IPR000960), Flavin-containing monooxygenase-like (InterPro:IPR020946); BEST Arabidopsis thaliana protein match is: flavin-monooxygenase glucosinolate S-oxygenase 3 (TAIR:AT1G62560.1); Has 11380 Blast hits to 10828 proteins in 1431 species: Archae - 28; Bacteria - 5328; Metazoa - 1193; Fungi - 1290; Plants - 802; Viruses - 0; Other Eukaryotes - 2739 (source: NCBI BLink).
    NP_172678.3
    • flavin-monooxygenase glucosinolate S-oxygenase 5 (FMO GS-OX5); FUNCTIONS IN: monooxygenase activity, 8-methylthiopropyl glucosinolate S-oxygenase activity, flavin-containing monooxygenase activity; INVOLVED IN: glucosinolate biosynthetic process; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Flavin-containing monooxygenase FMO (InterPro:IPR000960), Flavin-containing monooxygenase-like (InterPro:IPR020946); BEST Arabidopsis thaliana protein match is: flavin-monooxygenase glucosinolate S-oxygenase 3 (TAIR:AT1G62560.1); Has 12586 Blast hits to 12018 proteins in 1454 species: Archae - 35; Bacteria - 5986; Metazoa - 1231; Fungi - 1610; Plants - 812; Viruses - 0; Other Eukaryotes - 2912 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      4121285..4124595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101086.5 → NP_172678.3  flavin-monooxygenase glucosinolate S-oxygenase 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172678.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MRX0, Q9FWW4
      UniProtKB/TrEMBL
      A0A178WQ06, A0A5S9TYS0
      Conserved Domains (1) summary
      PLN02172
      Location:1 → 459
      PLN02172; flavin-containing monooxygenase FMO GS-OX

    2. NM_001084053.1 → NP_001077522.1  flavin-monooxygenase glucosinolate S-oxygenase 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077522.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MRX0
      Conserved Domains (2) summary
      PLN02172
      Location:1 → 457
      PLN02172; flavin-containing monooxygenase FMO GS-OX
      cl21454
      Location:21 → 235
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. NM_001332018.1 → NP_001323223.1  flavin-monooxygenase glucosinolate S-oxygenase 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MRX0, Q9FWW4
      UniProtKB/TrEMBL
      A0A178WQ06, A0A5S9TYS0
      Conserved Domains (1) summary
      PLN02172
      Location:1 → 459
      PLN02172; flavin-containing monooxygenase FMO GS-OX
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8MRX0.2

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