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    eEF-1Bb1 translation elongation factor EF1B/ribosomal protein S6 family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839903, updated on 18-Sep-2024

    Summary

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    Official Symbol
    eEF-1Bb1
    Official Full Name
    translation elongation factor EF1B/ribosomal protein S6 family protein
    Primary source
    TAIR:AT1G30230
    Locus tag
    AT1G30230
    See related
    Araport:AT1G30230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    EF1Bb; elongation factor 1B beta; eukaryotic elongation factor 1B beta 1; F12P21.12; F12P21_12
    Summary
    Encodes a guanine nucleotide exchange factor that plays an important role in translation elongation. It is localized in the plasma membrane and cytosol. Mutants display ectopic lignin deposition as well as cell expansion defects
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    Genomic context

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    See eEF-1Bb1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (10638878..10640941)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene TEOSINTE BRANCHED 1, cycloidea, and PCF family 24 Neighboring gene inositol transporter 2 Neighboring gene proline-, glutamic acid/leucine-rich protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The translation elongation factor eEF-1Bβ1 is involved in cell wall biosynthesis and plant development in Arabidopsis thaliana. Hossain Z, et al. PLoS One, 2012. PMID 22272350, Free PMC Article
    2. Class I and II Small Heat Shock Proteins Together with HSP101 Protect Protein Translation Factors during Heat Stress. McLoughlin F, et al. Plant Physiol, 2016 Oct. PMID 27474115, Free PMC Article
    3. Protein and metabolite composition of Arabidopsis stress granules. Kosmacz M, et al. New Phytol, 2019 May. PMID 30664249
    4. Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Klopffleisch K, et al. Mol Syst Biol, 2011 Sep 27. PMID 21952135, Free PMC Article
    5. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that both class I and II small heat shock proteins (sHSPs) were present in cytosolic foci, some of which colocalized with HSP101 and with eEF1Bgamma and eEF1Bbeta.
      Title: Class I and II Small Heat Shock Proteins Together with HSP101 Protect Protein Translation Factors during Heat Stress.
    2. Data strongly suggest a role for EF1Bbeta gene (At1g30230) in plant development and cell wall formation.
      Title: The translation elongation factor eEF-1Bβ1 is involved in cell wall biosynthesis and plant development in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NM_001084158.1
    NM_102762.5

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within lignin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type cell wall assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cellulose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation elongation factor 1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translation elongation factor EF1B/ribosomal protein S6 family protein
    NP_001077627.1
    • Glutathione S-transferase, C-terminal-like;Translation elongation factor EF1B/ribosomal protein S6; FUNCTIONS IN: translation elongation factor activity; INVOLVED IN: translational elongation; LOCATED IN: plasma membrane, eukaryotic translation elongation factor 1 complex; EXPRESSED IN: guard cell; CONTAINS InterPro DOMAIN/s: Translation elongation factor EF1B/ribosomal protein S6 (InterPro:IPR014717), Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange (InterPro:IPR014038), Glutathione S-transferase, C-terminal-like (InterPro:IPR010987), Translation elongation factor EF1B, beta/delta chains, conserved site (InterPro:IPR001326); BEST Arabidopsis thaliana protein match is: Translation elongation factor EF1B/ribosomal protein S6 family protein (TAIR:AT2G18110.1); Has 1008 Blast hits to 1006 proteins in 266 species: Archae - 0; Bacteria - 0; Metazoa - 526; Fungi - 158; Plants - 163; Viruses - 0; Other Eukaryotes - 161 (source: NCBI BLink).
    NP_174314.2
    • Glutathione S-transferase, C-terminal-like;Translation elongation factor EF1B/ribosomal protein S6; FUNCTIONS IN: translation elongation factor activity; INVOLVED IN: translational elongation, response to cadmium ion; LOCATED IN: plasma membrane, eukaryotic translation elongation factor 1 complex; EXPRESSED IN: guard cell, cultured cell, leaf; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Translation elongation factor EF1B/ribosomal protein S6 (InterPro:IPR014717), Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange (InterPro:IPR014038), Translation elongation factor EF1B, beta/delta chains, conserved site (InterPro:IPR001326); BEST Arabidopsis thaliana protein match is: Translation elongation factor EF1B/ribosomal protein S6 family protein (TAIR:AT2G18110.1); Has 1011 Blast hits to 1009 proteins in 269 species: Archae - 0; Bacteria - 0; Metazoa - 524; Fungi - 164; Plants - 164; Viruses - 0; Other Eukaryotes - 159 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      10638878..10640941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102762.5 → NP_174314.2  translation elongation factor EF1B/ribosomal protein S6 family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174314.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48006, Q0WWW7
      UniProtKB/TrEMBL
      A0A654EFT3, B3LF87
      Conserved Domains (2) summary
      pfam00736
      Location:145 → 231
      EF1_GNE; EF-1 guanine nucleotide exchange domain
      cl02776
      Location:1 → 63
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    2. NM_001084158.1 → NP_001077627.1  translation elongation factor EF1B/ribosomal protein S6 family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077627.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654EFT3, A8MRC4
      Conserved Domains (2) summary
      pfam00736
      Location:145 → 231
      EF1_GNE; EF-1 guanine nucleotide exchange domain
      cl02776
      Location:1 → 63
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48006.2

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