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    NRPB3 DNA-directed RNA polymerase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816035, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NRPB3
    Official Full Name
    DNA-directed RNA polymerase family protein
    Primary source
    TAIR:AT2G15430
    Locus tag
    AT2G15430
    See related
    Araport:AT2G15430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F26H6.5; F26H6_5; NRPD3; NRPE3A; RBP36A; RPB35.5A
    Summary
    Non-catalytic subunit of nuclear DNA-dependent RNA polymerases II, IV and V; homologous to budding yeast RPB3 and the E. coli RNA polymerase alpha subunit. A closely related paralog, encoded by At2g15400, can substitute for At2g15430 in the context of Pol V.
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    Genomic context

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    See NRPB3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Sequence:
    Chromosome: 2; NC_003071.7 (6733534..6735819)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene myosin heavy chain-like protein Neighboring gene ncRNA Neighboring gene polysaccharide biosynthesis protein (DUF579)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis. Chen L, et al. Development, 2016 May 1. PMID 26989174, Free PMC Article
    2. Arabidopsis CPL4 is an essential C-terminal domain phosphatase that suppresses xenobiotic stress responses. Fukudome A, et al. Plant J, 2014 Oct. PMID 25041272
    3. Association between 36- and 13.6-kDa alpha-like subunits of Arabidopsis thaliana RNA polymerase II. Ulmasov T, et al. J Biol Chem, 1996 Mar 1. PMID 8617787
    4. DTF1 is a core component of RNA-directed DNA methylation and may assist in the recruitment of Pol IV. Zhang H, et al. Proc Natl Acad Sci U S A, 2013 May 14. PMID 23637343, Free PMC Article
    5. A protein complex required for polymerase V transcripts and RNA- directed DNA methylation in Arabidopsis. Law JA, et al. Curr Biol, 2010 May 25. PMID 20409711, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    NM_001335452.1
    NM_127103.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within stomatal complex development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal complex patterning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II, core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase IV complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase V complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase family protein
    NP_179145.1
    • NRPB3; FUNCTIONS IN: DNA-directed RNA polymerase activity, protein dimerization activity, DNA binding; INVOLVED IN: transcription; LOCATED IN: in 6 components; CONTAINS InterPro DOMAIN/s: DNA-directed RNA polymerase, insert domain (InterPro:IPR011262), DNA-directed RNA polymerase, dimerisation (InterPro:IPR011261), DNA-directed RNA polymerase, RpoA/D/Rpb3-type (InterPro:IPR011263), DNA-directed RNA polymerase, 30-40kDa subunit, conserved site (InterPro:IPR001514), DNA-directed RNA polymerase, RBP11-like (InterPro:IPR009025); BEST Arabidopsis thaliana protein match is: DNA-directed RNA polymerase family protein (TAIR:AT2G15400.1); Has 1362 Blast hits to 1362 proteins in 353 species: Archae - 243; Bacteria - 1; Metazoa - 278; Fungi - 347; Plants - 109; Viruses - 0; Other Eukaryotes - 384 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      6733534..6735819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001335451.1 → NP_001324802.1  DNA-directed RNA polymerase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B178

    2. NM_127103.3 → NP_179145.1  DNA-directed RNA polymerase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179145.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39211
      UniProtKB/TrEMBL
      A0A178W202, A0A5S9WYB6, Q8LAJ1
      Conserved Domains (1) summary
      cd07031
      Location:10 → 302
      RNAP_II_RPB3; RPB3 subunit of Eukaryotic RNA polymerase II

    3. NM_001335452.1 → NP_001324803.1  DNA-directed RNA polymerase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B195
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39211.1

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