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    PIP2B plasma membrane intrinsic protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818293, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PIP2B
    Official Full Name
    plasma membrane intrinsic protein 2
    Primary source
    TAIR:AT2G37170
    Locus tag
    AT2G37170
    See related
    Araport:AT2G37170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    PIP2;2; plasma membrane intrinsic protein 2; PLASMA MEMBRANE INTRINSIC PROTEIN 2;2; T2N18.7; T2N18_7
    Summary
    a member of the plasma membrane intrinsic protein subfamily PIP2. localizes to the plasma membrane and exhibits water transport activity in Xenopus oocyte. expressed specifically in the vascular bundles and protein level increases slightly during leaf dev
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    Genomic context

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    See PIP2B in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (15613368..15615022, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Terpenoid synthases superfamily protein Neighboring gene RING/U-box superfamily protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene microRNA ath-MIR1886 precursor Neighboring gene Aquaporin-like superfamily protein Neighboring gene Ribosomal protein L11 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ERAD-related E2 and E3 enzymes modulate the drought response by regulating the stability of PIP2 aquaporins. Chen Q, et al. Plant Cell, 2021 Aug 31. PMID 34015125, Free PMC Article
    2. Evidence for in vivo interactions between dehydrins and the aquaporin AtPIP2B. Hernández-Sánchez IE, et al. Biochem Biophys Res Commun, 2019 Mar 19. PMID 30738581
    3. Water channels in the plant plasma membrane cloned by immunoselection from a mammalian expression system. Kammerloher W, et al. Plant J, 1994 Aug. PMID 7920711
    4. Whole gene family expression and drought stress regulation of aquaporins. Alexandersson E, et al. Plant Mol Biol, 2005 Oct. PMID 16235111
    5. A membrane protein/signaling protein interaction network for Arabidopsis version AMPv2. Lalonde S, et al. Front Physiol, 2010. PMID 21423366, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ERAD-related E2 and E3 enzymes modulate the drought response by regulating the stability of PIP2 aquaporins.
      Title: ERAD-related E2 and E3 enzymes modulate the drought response by regulating the stability of PIP2 aquaporins.
    2. The COR47, ERD10, and RAB18 Arabidopsis dehydrins are able to interact with PIP2B in planta.
      Title: Evidence for in vivo interactions between dehydrins and the aquaporin AtPIP2B.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_129273.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    enables water channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables water channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within water transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    plasma membrane intrinsic protein 2
    NP_181254.1
    • plasma membrane intrinsic protein 2 (PIP2B); FUNCTIONS IN: water channel activity; INVOLVED IN: response to water deprivation, response to salt stress, transport, water transport; LOCATED IN: plasma membrane, chloroplast, membrane; EXPRESSED IN: root, cultured cell, callus; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Major intrinsic protein, conserved site (InterPro:IPR022357), Aquaporin (InterPro:IPR012269), Major intrinsic protein (InterPro:IPR000425); BEST Arabidopsis thaliana protein match is: Aquaporin-like superfamily protein (TAIR:AT2G37180.1); Has 10851 Blast hits to 10838 proteins in 2234 species: Archae - 81; Bacteria - 5194; Metazoa - 1467; Fungi - 455; Plants - 2519; Viruses - 2; Other Eukaryotes - 1133 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      15613368..15615022 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336641.1 → NP_001323849.1  plasma membrane intrinsic protein 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VXV5, A0A1P8AYA1, A0A5S9X4P6

    2. NM_129273.5 → NP_181254.1  plasma membrane intrinsic protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181254.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P43287, Q8L5U5, Q9SKR8
      UniProtKB/TrEMBL
      A0A178VXV5, A0A5S9X4P6
      Conserved Domains (1) summary
      pfam00230
      Location:29 → 264
      MIP; Major intrinsic protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43287.2

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