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    CARA carbamoyl phosphate synthetase A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822396, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CARA
    Official Full Name
    carbamoyl phosphate synthetase A
    Primary source
    TAIR:AT3G27740
    Locus tag
    AT3G27740
    See related
    Araport:AT3G27740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    carbamoyl phosphate synthetase A; CARBAMOYL PHOSPHATE SYNTHETASE SMALL SUBUNIT; VEN6; VENOSA 6
    Summary
    Encodes carbamoyl phosphate synthetase (CPS) small subunit (carA), also named as VEN6. Heterologous expression of the Arabidopsis VEN3 and VEN6 genes in a CPS-deficient Escherichia coli strain fully restored bacterial growth in minimal medium, demonstrating the enzymatic activity of the VEN3 and VEN6 proteins.
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    Genomic context

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    See CARA in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Sequence:
    Chromosome: 3; NC_003074.8 (10281230..10283935, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene IBR domain containing protein Neighboring gene DNA helicase ROCK-N-ROLLERS Neighboring gene ncRNA Neighboring gene PPR containing protein Neighboring gene plant/protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of ven3 and ven6 reticulate mutants reveals the importance of arginine biosynthesis in Arabidopsis leaf development. Mollá-Morales A, et al. Plant J, 2011 Feb. PMID 21265888
    2. Effects of phosphate limitation on expression of genes involved in pyrimidine synthesis and salvaging in Arabidopsis. Hewitt MM, et al. Plant Physiol Biochem, 2005 Feb. PMID 15820655
    3. The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Peltier JB, et al. Mol Cell Proteomics, 2006 Jan. PMID 16207701
    4. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article
    5. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001084749.1
    NM_113690.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' UMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-arginine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to phosphate starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of carbamoyl-phosphate synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    carbamoyl phosphate synthetase A
    NP_001078218.1
    • carbamoyl phosphate synthetase A (CARA); FUNCTIONS IN: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity, catalytic activity; INVOLVED IN: cellular response to phosphate starvation; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Glutamine amidotransferase class-I, C-terminal (InterPro:IPR000991), Glutamine amidotransferase superfamily (InterPro:IPR011702), Carbamoyl phosphate synthase, GATase domain (InterPro:IPR001317), Carbamoyl phosphate synthase, small subunit, N-terminal (InterPro:IPR002474), Glutamine amidotransferase type 1 (InterPro:IPR017926), Carbamoyl phosphate synthase, small subunit (InterPro:IPR006274), Anthranilate synthase component II/delta crystallin (InterPro:IPR006220); BEST Arabidopsis thaliana protein match is: anthranilate synthase beta subunit 1 (TAIR:AT1G25220.1); Has 28262 Blast hits to 23423 proteins in 4115 species: Archae - 591; Bacteria - 17320; Metazoa - 1741; Fungi - 716; Plants - 245; Viruses - 0; Other Eukaryotes - 7649 (source: NCBI BLink).
    NP_566824.1
    • carbamoyl phosphate synthetase A (CARA); FUNCTIONS IN: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity, catalytic activity; INVOLVED IN: cellular response to phosphate starvation; LOCATED IN: chloroplast, chloroplast stroma; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Glutamine amidotransferase class-I, C-terminal (InterPro:IPR000991), Glutamine amidotransferase superfamily (InterPro:IPR011702), Carbamoyl phosphate synthase, GATase domain (InterPro:IPR001317), Carbamoyl phosphate synthase, small subunit, N-terminal (InterPro:IPR002474), Glutamine amidotransferase type 1 (InterPro:IPR017926), Carbamoyl phosphate synthase, small subunit (InterPro:IPR006274), Anthranilate synthase component II/delta crystallin (InterPro:IPR006220); BEST Arabidopsis thaliana protein match is: anthranilate synthase beta subunit 1 (TAIR:AT1G25220.1); Has 23531 Blast hits to 23511 proteins in 4128 species: Archae - 520; Bacteria - 13864; Metazoa - 1675; Fungi - 510; Plants - 198; Viruses - 0; Other Eukaryotes - 6764 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      10281230..10283935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113690.3 → NP_566824.1  carbamoyl phosphate synthetase A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566824.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O24447, Q9LVW7
      UniProtKB/TrEMBL
      A0A178VAM7, A0A7G2ENW7
      Conserved Domains (1) summary
      PLN02771
      Location:1 → 416
      PLN02771; carbamoyl-phosphate synthase (glutamine-hydrolyzing)

    2. NM_001084749.1 → NP_001078218.1  carbamoyl phosphate synthetase A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078218.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2ENW7, A8MRD8
      Conserved Domains (3) summary
      cd01744
      Location:172 → 348
      GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
      PLN02771
      Location:1 → 344
      PLN02771; carbamoyl-phosphate synthase (glutamine-hydrolyzing)
      pfam00988
      Location:58 → 122
      CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LVW7.1

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