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    GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 [ Homo sapiens (human) ]

    Gene ID: 2982, updated on 27-Nov-2024

    Summary

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    Official Symbol
    GUCY1A1provided by HGNC
    Official Full Name
    guanylate cyclase 1 soluble subunit alpha 1provided by HGNC
    Primary source
    HGNC:HGNC:4685
    See related
    Ensembl:ENSG00000164116 MIM:139396; AllianceGenome:HGNC:4685
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GUCA3; MYMY6; GC-SA3; GUC1A3; GUCSA3; GUCY1A3; GCS-alpha-3; GC-S-alpha-1
    Summary
    Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
    Expression
    Ubiquitous expression in prostate (RPKM 11.3), heart (RPKM 8.5) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GUCY1A1 in Genome Data Viewer
    Location:
    4q32.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (155666848..155737059)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (158999647..159069856)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (156588000..156658211)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377505 Neighboring gene uncharacterized LOC105377504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:156473069-156473570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:156473571-156474070 Neighboring gene Sharpr-MPRA regulatory region 7198 Neighboring gene uncharacterized LOC105377506 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15770 Neighboring gene guanylate cyclase 1 soluble subunit beta 1 Neighboring gene uncharacterized LOC105377507 Neighboring gene acid sensing ion channel subunit family member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Assignment of GUCY1A3, a candidate gene for hypertension, to human chromosome bands 4q31.1-->q31.2 by in situ hybridization. Behrends S, et al. Cytogenet Cell Genet, 2000. PMID 10828587
    2. Loss of α1β1 soluble guanylate cyclase, the major nitric oxide receptor, leads to moyamoya and achalasia. Hervé D, et al. Am J Hum Genet, 2014 Mar 6. PMID 24581742, Free PMC Article
    3. α1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among Kyrgyz highlanders. Wilkins MR, et al. Circ Cardiovasc Genet, 2014 Dec. PMID 25373139
    4. Disrupted nitric oxide signaling due to GUCY1A3 mutations increases risk for moyamoya disease, achalasia and hypertension. Wallace S, et al. Clin Genet, 2016 Oct. PMID 26777256, Free PMC Article
    5. Stimulators of the soluble guanylyl cyclase: promising functional insights from rare coding atherosclerosis-related GUCY1A3 variants. Wobst J, et al. Basic Res Cardiol, 2016 Jul. PMID 27342234

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biallelic variants in NOS3 and GUCY1A3, the two major genes of the nitric oxide pathway, cause moyamoya cerebral angiopathy.
      Title: Biallelic variants in NOS3 and GUCY1A3, the two major genes of the nitric oxide pathway, cause moyamoya cerebral angiopathy.
    2. Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
      Title: Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
    3. Higher susceptibility to heme oxidation and lower protein stability of the rare alpha1C517Ybeta1 sGC variant associated with moyamoya syndrome.
      Title: Higher susceptibility to heme oxidation and lower protein stability of the rare α(1)C517Yβ(1) sGC variant associated with moyamoya syndrome.
    4. Inflammation in the Human Periodontium Induces Downregulation of the alpha1- and beta1-Subunits of the sGC in Cementoclasts.
      Title: Inflammation in the Human Periodontium Induces Downregulation of the α(1)- and β(1)-Subunits of the sGC in Cementoclasts.
    5. Soluble guanylyl cyclase alpha1 subunit is a key mediator of proliferation, survival, and migration in ECC-1 and HeLa cell lines.
      Title: Soluble guanylyl cyclase α1 subunit is a key mediator of proliferation, survival, and migration in ECC-1 and HeLa cell lines.
    6. Genetic variation at the coronary artery disease risk locus GUCY1A3 modifies cardiovascular disease prevention effects of aspirin.
      Title: Genetic variation at the coronary artery disease risk locus GUCY1A3 modifies cardiovascular disease prevention effects of aspirin.
    7. Results suggest mechanistic insights into the molecular pathway for soluble guanylyl cyclase (sGC) activation.
      Title: Synergistic mutations in soluble guanylyl cyclase (sGC) reveal a key role for interfacial regions in the sGC activation mechanism.
    8. Homozygous GUCY1A3 risk allele carriers are at increased risk of cardiovascular death or stent thrombosis within 30 days after coronary stenting, likely due to higher on-aspirin platelet reactivity.
      Title: Association of the coronary artery disease risk gene GUCY1A3 with ischaemic events after coronary intervention.
    9. Our results indicate that the GUCY1A3 rs1842896 polymorphism is an large artery atherosclerotic (LAA) stroke risk factor in Southern Han Chinese.
      Title: Associations between GUCY1A3 genetic polymorphisms and large artery atherosclerotic stroke risk in Chinese Han population: a case-control study.
    10. Genetic predisposition to enhanced nitric oxide signaling was associated with reduced blood pressure, improved renal and pulmonary function, and significantly reduced risks of coronary heart disease in people with rs7692387 GUCY1A3 variant.
      Title: Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Moyamoya disease with early-onset achalasia
    MedGen: C3810403 OMIM: 615750 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
    EBI GWAS Catalog
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    EBI GWAS Catalog
    Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
    EBI GWAS Catalog
    Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat potentiates NMDA-evoked (Ca2+)I responses involve LRP and a Src family kinase via the NOS/sGC/PKG pathway PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in blood circulation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nitric oxide mediated signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in nitric oxide-cGMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of nitric oxide mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in relaxation of vascular associated smooth muscle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxygen levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of guanylate cyclase complex, soluble IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of guanylate cyclase complex, soluble IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of guanylate cyclase complex, soluble IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanylate cyclase soluble subunit alpha-1
    Names
    guanylate cyclase 1, soluble, alpha 3
    soluble guanylate cyclase large subunit
    NP_000847.2
    NP_001124154.1
    NP_001124155.1
    NP_001124156.1
    NP_001124157.1
    NP_001124159.1
    NP_001243378.1
    NP_001366595.1
    NP_001366596.1
    NP_001366597.1
    NP_001366598.1
    NP_001366599.1
    NP_001366600.1
    NP_001366601.1
    NP_001366602.1
    NP_001366603.1
    NP_001366604.1
    NP_001366605.1
    XP_005263013.1
    XP_005263014.1
    XP_047306099.1
    XP_047306100.1
    XP_047306102.1
    XP_047306103.1
    XP_047306104.1
    XP_054205815.1
    XP_054205816.1
    XP_054205817.1
    XP_054205818.1
    XP_054205819.1
    XP_054205820.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034128.1 RefSeqGene

      Range
      5139..75350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000856.6 → NP_000847.2  guanylate cyclase soluble subunit alpha-1 isoform A

      See identical proteins and their annotated locations for NP_000847.2

      Status: REVIEWED

      Source sequence(s)
      AC104083, CD671731, Y15723
      Consensus CDS
      CCDS34085.1
      UniProtKB/Swiss-Prot
      D3DP19, D6RDW3, O43843, Q02108, Q8TAH3
      UniProtKB/TrEMBL
      B3KU69
      Related
      ENSP00000421493.1, ENST00000511108.5
      Conserved Domains (2) summary
      pfam00211
      Location:472 → 643
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:277 → 466
      HNOBA; Heme NO binding associated

    2. NM_001130682.3 → NP_001124154.1  guanylate cyclase soluble subunit alpha-1 isoform A

      See identical proteins and their annotated locations for NP_001124154.1

      Status: REVIEWED

      Source sequence(s)
      AC104083, CD671731, DA793192, Y15723
      Consensus CDS
      CCDS34085.1
      UniProtKB/Swiss-Prot
      D3DP19, D6RDW3, O43843, Q02108, Q8TAH3
      UniProtKB/TrEMBL
      B3KU69
      Related
      ENSP00000424361.1, ENST00000506455.6
      Conserved Domains (2) summary
      pfam00211
      Location:472 → 643
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:277 → 466
      HNOBA; Heme NO binding associated

    3. NM_001130683.4 → NP_001124155.1  guanylate cyclase soluble subunit alpha-1 isoform A

      See identical proteins and their annotated locations for NP_001124155.1

      Status: REVIEWED

      Source sequence(s)
      AC104083, AK226125, BX649180, CD671731, DA518091
      Consensus CDS
      CCDS34085.1
      UniProtKB/Swiss-Prot
      D3DP19, D6RDW3, O43843, Q02108, Q8TAH3
      UniProtKB/TrEMBL
      B3KU69
      Related
      ENSP00000296518.7, ENST00000296518.11
      Conserved Domains (2) summary
      pfam00211
      Location:472 → 643
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:277 → 466
      HNOBA; Heme NO binding associated

    4. NM_001130684.3 → NP_001124156.1  guanylate cyclase soluble subunit alpha-1 isoform A

      See identical proteins and their annotated locations for NP_001124156.1

      Status: REVIEWED

      Source sequence(s)
      AC104083, CD671731, Y15723
      Consensus CDS
      CCDS34085.1
      UniProtKB/Swiss-Prot
      D3DP19, D6RDW3, O43843, Q02108, Q8TAH3
      UniProtKB/TrEMBL
      B3KU69
      Related
      ENSP00000426040.1, ENST00000513574.1
      Conserved Domains (2) summary
      pfam00211
      Location:472 → 643
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:277 → 466
      HNOBA; Heme NO binding associated

    5. NM_001130685.3 → NP_001124157.1  guanylate cyclase soluble subunit alpha-1 isoform B

      See identical proteins and their annotated locations for NP_001124157.1

      Status: REVIEWED

      Source sequence(s)
      AC104083, AK226125, CD671731, DA518091
      UniProtKB/TrEMBL
      J3KPQ8
      Related
      ENSP00000377418.3, ENST00000393832.7
      Conserved Domains (4) summary
      smart00044
      Location:210 → 399
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:237 → 408
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:42 → 231
      HNOBA; Heme NO binding associated
      cl01153
      Location:395 → 441
      NapB; Nitrate reductase cytochrome c-type subunit (NapB)

    6. NM_001130687.3 → NP_001124159.1  guanylate cyclase soluble subunit alpha-1 isoform D

      Status: REVIEWED

      Source sequence(s)
      AC104083
      Consensus CDS
      CCDS54812.1
      UniProtKB/TrEMBL
      B3KU69
      Related
      ENSP00000426968.1, ENST00000511507.5
      Conserved Domains (4) summary
      smart00044
      Location:445 → 624
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:472 → 624
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:126 → 235
      HNOB; Haem-NO-binding
      pfam07701
      Location:277 → 466
      HNOBA; Heme NO binding associated

    7. NM_001256449.2 → NP_001243378.1  guanylate cyclase soluble subunit alpha-1 isoform A

      See identical proteins and their annotated locations for NP_001243378.1

      Status: REVIEWED

      Source sequence(s)
      AC104083, AK096588, CD671731, Y15723
      Consensus CDS
      CCDS34085.1
      UniProtKB/Swiss-Prot
      D3DP19, D6RDW3, O43843, Q02108, Q8TAH3
      UniProtKB/TrEMBL
      B3KU69
      Related
      ENSP00000412201.2, ENST00000455639.6
      Conserved Domains (2) summary
      pfam00211
      Location:472 → 643
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:277 → 466
      HNOBA; Heme NO binding associated

    8. NM_001379666.1 → NP_001366595.1  guanylate cyclase soluble subunit alpha-1 isoform A

      Status: REVIEWED

      Source sequence(s)
      AC104083
      Consensus CDS
      CCDS34085.1
      UniProtKB/Swiss-Prot
      D3DP19, D6RDW3, O43843, Q02108, Q8TAH3
      UniProtKB/TrEMBL
      B3KU69
      Conserved Domains (2) summary
      pfam00211
      Location:472 → 643
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:277 → 466
      HNOBA; Heme NO binding associated

    9. NM_001379667.1 → NP_001366596.1  guanylate cyclase soluble subunit alpha-1 isoform A

      Status: REVIEWED

      Source sequence(s)
      AC104083
      Consensus CDS
      CCDS34085.1
      UniProtKB/Swiss-Prot
      D3DP19, D6RDW3, O43843, Q02108, Q8TAH3
      UniProtKB/TrEMBL
      B3KU69
      Conserved Domains (2) summary
      pfam00211
      Location:472 → 643
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:277 → 466
      HNOBA; Heme NO binding associated

    10. NM_001379668.1 → NP_001366597.1  guanylate cyclase soluble subunit alpha-1 isoform A

      Status: REVIEWED

      Source sequence(s)
      AC104083
      Consensus CDS
      CCDS34085.1
      UniProtKB/Swiss-Prot
      D3DP19, D6RDW3, O43843, Q02108, Q8TAH3
      UniProtKB/TrEMBL
      B3KU69
      Conserved Domains (2) summary
      pfam00211
      Location:472 → 643
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:277 → 466
      HNOBA; Heme NO binding associated

    11. NM_001379669.1 → NP_001366598.1  guanylate cyclase soluble subunit alpha-1 isoform A

      Status: REVIEWED

      Source sequence(s)
      AC104083
      Consensus CDS
      CCDS34085.1
      UniProtKB/Swiss-Prot
      D3DP19, D6RDW3, O43843, Q02108, Q8TAH3
      UniProtKB/TrEMBL
      B3KU69
      Conserved Domains (2) summary
      pfam00211
      Location:472 → 643
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:277 → 466
      HNOBA; Heme NO binding associated

    12. NM_001379670.1 → NP_001366599.1  guanylate cyclase soluble subunit alpha-1 isoform A

      Status: REVIEWED

      Source sequence(s)
      AC104083
      Consensus CDS
      CCDS34085.1
      UniProtKB/Swiss-Prot
      D3DP19, D6RDW3, O43843, Q02108, Q8TAH3
      UniProtKB/TrEMBL
      B3KU69
      Conserved Domains (2) summary
      pfam00211
      Location:472 → 643
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:277 → 466
      HNOBA; Heme NO binding associated

    13. NM_001379671.1 → NP_001366600.1  guanylate cyclase soluble subunit alpha-1 isoform A

      Status: REVIEWED

      Source sequence(s)
      AC104083
      Consensus CDS
      CCDS34085.1
      UniProtKB/Swiss-Prot
      D3DP19, D6RDW3, O43843, Q02108, Q8TAH3
      UniProtKB/TrEMBL
      B3KU69
      Conserved Domains (2) summary
      pfam00211
      Location:472 → 643
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:277 → 466
      HNOBA; Heme NO binding associated

    14. NM_001379672.1 → NP_001366601.1  guanylate cyclase soluble subunit alpha-1 isoform A

      Status: REVIEWED

      Source sequence(s)
      AC104083
      Consensus CDS
      CCDS34085.1
      UniProtKB/Swiss-Prot
      D3DP19, D6RDW3, O43843, Q02108, Q8TAH3
      UniProtKB/TrEMBL
      B3KU69
      Conserved Domains (2) summary
      pfam00211
      Location:472 → 643
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:277 → 466
      HNOBA; Heme NO binding associated

    15. NM_001379673.1 → NP_001366602.1  guanylate cyclase soluble subunit alpha-1 isoform A

      Status: REVIEWED

      Source sequence(s)
      AC104083
      Consensus CDS
      CCDS34085.1
      UniProtKB/Swiss-Prot
      D3DP19, D6RDW3, O43843, Q02108, Q8TAH3
      UniProtKB/TrEMBL
      B3KU69
      Conserved Domains (2) summary
      pfam00211
      Location:472 → 643
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:277 → 466
      HNOBA; Heme NO binding associated

    16. NM_001379674.1 → NP_001366603.1  guanylate cyclase soluble subunit alpha-1 isoform A

      Status: REVIEWED

      Source sequence(s)
      AC104083
      Consensus CDS
      CCDS34085.1
      UniProtKB/Swiss-Prot
      D3DP19, D6RDW3, O43843, Q02108, Q8TAH3
      UniProtKB/TrEMBL
      B3KU69
      Conserved Domains (2) summary
      pfam00211
      Location:472 → 643
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:277 → 466
      HNOBA; Heme NO binding associated

    17. NM_001379675.1 → NP_001366604.1  guanylate cyclase soluble subunit alpha-1 isoform E

      Status: REVIEWED

      Source sequence(s)
      AC104083
      UniProtKB/TrEMBL
      B3KU69
      Conserved Domains (2) summary
      smart00044
      Location:445 → 573
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam07701
      Location:277 → 466
      HNOBA; Heme NO binding associated

    18. NM_001379676.1 → NP_001366605.1  guanylate cyclase soluble subunit alpha-1 isoform F

      Status: REVIEWED

      Source sequence(s)
      AC104083
      Conserved Domains (2) summary
      pfam00211
      Location:303 → 474
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:126 → 297
      HNOBA; Heme NO binding associated

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      155666848..155737059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005262957.4 → XP_005263014.1  guanylate cyclase soluble subunit alpha-1 isoform X3

      See identical proteins and their annotated locations for XP_005263014.1

      UniProtKB/TrEMBL
      J3KPQ8
      Conserved Domains (4) summary
      smart00044
      Location:210 → 399
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:237 → 408
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:42 → 231
      HNOBA; Heme NO binding associated
      cl01153
      Location:395 → 441
      NapB; Nitrate reductase cytochrome c-type subunit (NapB)

    2. XM_047450144.1 → XP_047306100.1  guanylate cyclase soluble subunit alpha-1 isoform X1

      UniProtKB/Swiss-Prot
      D3DP19, D6RDW3, O43843, Q02108, Q8TAH3

    3. XM_005262956.4 → XP_005263013.1  guanylate cyclase soluble subunit alpha-1 isoform X3

      See identical proteins and their annotated locations for XP_005263013.1

      UniProtKB/TrEMBL
      J3KPQ8
      Conserved Domains (4) summary
      smart00044
      Location:210 → 399
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:237 → 408
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:42 → 231
      HNOBA; Heme NO binding associated
      cl01153
      Location:395 → 441
      NapB; Nitrate reductase cytochrome c-type subunit (NapB)

    4. XM_047450148.1 → XP_047306104.1  guanylate cyclase soluble subunit alpha-1 isoform X3

    5. XM_047450143.1 → XP_047306099.1  guanylate cyclase soluble subunit alpha-1 isoform X1

      UniProtKB/Swiss-Prot
      D3DP19, D6RDW3, O43843, Q02108, Q8TAH3

    6. XM_047450146.1 → XP_047306102.1  guanylate cyclase soluble subunit alpha-1 isoform X1

      UniProtKB/Swiss-Prot
      D3DP19, D6RDW3, O43843, Q02108, Q8TAH3

    7. XM_047450147.1 → XP_047306103.1  guanylate cyclase soluble subunit alpha-1 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      158999647..159069856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349844.1 → XP_054205819.1  guanylate cyclase soluble subunit alpha-1 isoform X3

    2. XM_054349840.1 → XP_054205815.1  guanylate cyclase soluble subunit alpha-1 isoform X1

      UniProtKB/Swiss-Prot
      D3DP19, D6RDW3, O43843, Q02108, Q8TAH3

    3. XM_054349843.1 → XP_054205818.1  guanylate cyclase soluble subunit alpha-1 isoform X3

    4. XM_054349845.1 → XP_054205820.1  guanylate cyclase soluble subunit alpha-1 isoform X3

    5. XM_054349841.1 → XP_054205816.1  guanylate cyclase soluble subunit alpha-1 isoform X1

      UniProtKB/Swiss-Prot
      D3DP19, D6RDW3, O43843, Q02108, Q8TAH3

    6. XM_054349842.1 → XP_054205817.1  guanylate cyclase soluble subunit alpha-1 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001130686.1: Suppressed sequence

      Description
      NM_001130686.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02108.2 GenPept UniProtKB/Swiss-Prot:Q02108

    Gene LinkOut

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