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    THNSL1 threonine synthase like 1 [ Homo sapiens (human) ]

    Gene ID: 79896, updated on 9-Dec-2024

    Summary

    Official Symbol
    THNSL1provided by HGNC
    Official Full Name
    threonine synthase like 1provided by HGNC
    Primary source
    HGNC:HGNC:26160
    See related
    Ensembl:ENSG00000185875 MIM:611260; AllianceGenome:HGNC:26160
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TSH1
    Summary
    Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver (RPKM 5.2), thyroid (RPKM 5.2) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See THNSL1 in Genome Data Viewer
    Location:
    10p12.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (24952364..25026664)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (24970612..25044892)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (25305541..25315593)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376456 Neighboring gene MPRA-validated peak910 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:25051766-25052318 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3160 Neighboring gene phosphoribosyl transferase domain containing 1 Neighboring gene NFE2L2 motif-containing MPRA enhancer 245 Neighboring gene RN7SK pseudogene 241 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2229 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:25305216-25305978 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3162 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:25348855-25350054 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:25350646-25351845 Neighboring gene enkurin, TRPC channel interacting protein Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:25356859-25358058 Neighboring gene NANOG hESC enhancer GRCh37_chr10:25394727-25395330 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2233 Neighboring gene long intergenic non-protein coding RNA 1516 Neighboring gene GPR158 antisense RNA 1 Neighboring gene G protein-coupled receptor 158 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:25542036-25542637 Neighboring gene RN7SK pseudogene 220

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024838.5NP_079114.3  threonine synthase-like 1

      See identical proteins and their annotated locations for NP_079114.3

      Status: VALIDATED

      Source sequence(s)
      AK025655, AK125249, BX647989, DA496769
      Consensus CDS
      CCDS7147.1
      UniProtKB/Swiss-Prot
      B3KWL1, D3DRV3, Q5VV21, Q8IYQ7
      Related
      ENSP00000365534.4, ENST00000376356.5
      Conserved Domains (5) summary
      cd01560
      Location:230733
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
      PRK00131
      Location:56223
      aroK; shikimate kinase; Reviewed
      PRK09225
      Location:231739
      PRK09225; threonine synthase; Validated
      cd00464
      Location:57211
      SK; Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis ...
      cl21455
      Location:1478
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      24952364..25026664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016665.2XP_016872154.1  threonine synthase-like 1 isoform X1

      UniProtKB/Swiss-Prot
      B3KWL1, D3DRV3, Q5VV21, Q8IYQ7
      Conserved Domains (5) summary
      cd01560
      Location:230733
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
      PRK00131
      Location:56223
      aroK; shikimate kinase; Reviewed
      PRK09225
      Location:231739
      PRK09225; threonine synthase; Validated
      cd00464
      Location:57211
      SK; Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis ...
      cl21455
      Location:1478
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. XM_047425764.1XP_047281720.1  threonine synthase-like 1 isoform X1

      UniProtKB/Swiss-Prot
      B3KWL1, D3DRV3, Q5VV21, Q8IYQ7
    3. XM_005252597.4XP_005252654.1  threonine synthase-like 1 isoform X1

      See identical proteins and their annotated locations for XP_005252654.1

      UniProtKB/Swiss-Prot
      B3KWL1, D3DRV3, Q5VV21, Q8IYQ7
      Related
      ENSP00000434887.1, ENST00000524413.5
      Conserved Domains (5) summary
      cd01560
      Location:230733
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
      PRK00131
      Location:56223
      aroK; shikimate kinase; Reviewed
      PRK09225
      Location:231739
      PRK09225; threonine synthase; Validated
      cd00464
      Location:57211
      SK; Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis ...
      cl21455
      Location:1478
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      24970612..25044892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366762.1XP_054222737.1  threonine synthase-like 1 isoform X1

    2. XM_054366760.1XP_054222735.1  threonine synthase-like 1 isoform X1

    3. XM_054366761.1XP_054222736.1  threonine synthase-like 1 isoform X1