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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001278185.2 → NP_001265114.1 probable E3 ubiquitin-protein ligase HERC4 isoform c
Status: VALIDATED
- Description
- Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
- Source sequence(s)
-
AY650032, AY650033, BC018114
- Consensus CDS
-
CCDS60541.1
- UniProtKB/TrEMBL
-
A8K9U4
- Related
- ENSP00000416504.2, ENST00000412272.6
- Conserved Domains (3) summary
-
- smart00119
Location:735 → 976
- HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
- cd00078
Location:709 → 977
- HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
- pfam00415
Location:208 → 257
- RCC1; Regulator of chromosome condensation (RCC1) repeat
-
NM_001278186.2 → NP_001265115.1 probable E3 ubiquitin-protein ligase HERC4 isoform d
See identical proteins and their annotated locations for NP_001265115.1
Status: VALIDATED
- Description
- Transcript Variant: This variant (4) lacks two alternate exons compared to variant 1, and one causes a frameshift. These differences cause translation initiation at a downstream AUG and result in an isoform (d) with a shorter and distinct N-terminus and lacking an alternate internal segment, compared to isoform 1.
- Source sequence(s)
-
AY650032, BC018114
- UniProtKB/Swiss-Prot
-
Q5GLZ8
- Conserved Domains (3) summary
-
- smart00119
Location:472 → 791
- HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
- cd00078
Location:446 → 792
- HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
- pfam00415
Location:5 → 53
- RCC1; Regulator of chromosome condensation (RCC1) repeat
-
NM_001278187.2 → NP_001265116.1 probable E3 ubiquitin-protein ligase HERC4 isoform e
See identical proteins and their annotated locations for NP_001265116.1
Status: VALIDATED
- Description
- Transcript Variant: This variant (5) has an alternate 3'-most exon in place of most of the rest of the transcript compared to variant 1. The resulting isoform (e) has a shorter and distinct C-terminus compared to isoform a.
- Source sequence(s)
-
AC024258, AY650034, BX101651
- Consensus CDS
-
CCDS60542.1
- UniProtKB/Swiss-Prot
-
Q5GLZ8
- Related
- ENSP00000422383.1, ENST00000492996.6
- Conserved Domains (1) summary
-
- COG5184
Location:2 → 69
- ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
-
NM_015601.4 → NP_056416.2 probable E3 ubiquitin-protein ligase HERC4 isoform b
See identical proteins and their annotated locations for NP_056416.2
Status: VALIDATED
- Description
- Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
- Source sequence(s)
-
BC018114, BC039600, DB459623
- Consensus CDS
-
CCDS7274.1
- UniProtKB/TrEMBL
-
A8K9U4
- Related
- ENSP00000362804.4, ENST00000373700.9
- Conserved Domains (2) summary
-
- cd00078
Location:701 → 1047
- HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
- cl27697
Location:2 → 344
- RCC1; Regulator of chromosome condensation (RCC1) repeat
-
NM_022079.3 → NP_071362.1 probable E3 ubiquitin-protein ligase HERC4 isoform a
See identical proteins and their annotated locations for NP_071362.1
Status: VALIDATED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
- Source sequence(s)
-
AY221963, BC015043, BC018114
- Consensus CDS
-
CCDS41533.1
- UniProtKB/Swiss-Prot
- Q5GC98, Q5GC99, Q5GCA0, Q5GLZ8, Q8IXP9, Q9HCH9
- UniProtKB/TrEMBL
-
A8K9U4
- Related
- ENSP00000378624.3, ENST00000395198.7
- Conserved Domains (2) summary
-
- cd00078
Location:709 → 1055
- HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
- cl27697
Location:2 → 344
- RCC1; Regulator of chromosome condensation (RCC1) repeat
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000010.11 Reference GRCh38.p14 Primary Assembly
- Range
-
67921905..68075283 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047424999.1 → XP_047280955.1 probable E3 ubiquitin-protein ligase HERC4 isoform X11
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_017016041.3 → XP_016871530.1 probable E3 ubiquitin-protein ligase HERC4 isoform X10
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_047424998.1 → XP_047280954.1 probable E3 ubiquitin-protein ligase HERC4 isoform X9
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_011539597.4 → XP_011537899.1 probable E3 ubiquitin-protein ligase HERC4 isoform X8
- UniProtKB/TrEMBL
-
A8K9U4
- Conserved Domains (3) summary
-
- smart00119
Location:638 → 957
- HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
- cd00078
Location:612 → 958
- HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
- pfam00415
Location:232 → 281
- RCC1; Regulator of chromosome condensation (RCC1) repeat
-
XM_011539593.4 → XP_011537895.1 probable E3 ubiquitin-protein ligase HERC4 isoform X2
- UniProtKB/TrEMBL
-
A8K9U4
- Conserved Domains (3) summary
-
- smart00119
Location:751 → 1070
- HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
- cd00078
Location:725 → 1071
- HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
- pfam00415
Location:232 → 281
- RCC1; Regulator of chromosome condensation (RCC1) repeat
-
XM_011539592.4 → XP_011537894.1 probable E3 ubiquitin-protein ligase HERC4 isoform X1
- UniProtKB/TrEMBL
-
A8K9U4
- Conserved Domains (2) summary
-
- COG5184
Location:2 → 368
- ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
- cd00078
Location:733 → 1079
- HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
-
XM_024447930.2 → XP_024303698.1 probable E3 ubiquitin-protein ligase HERC4 isoform X3
- UniProtKB/Swiss-Prot
- Q5GC98, Q5GC99, Q5GCA0, Q5GLZ8, Q8IXP9, Q9HCH9
- UniProtKB/TrEMBL
-
A8K9U4
- Conserved Domains (2) summary
-
- cd00078
Location:709 → 1055
- HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
- cl27697
Location:2 → 344
- RCC1; Regulator of chromosome condensation (RCC1) repeat
-
XM_047424990.1 → XP_047280946.1 probable E3 ubiquitin-protein ligase HERC4 isoform X1
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_047425000.1 → XP_047280956.1 probable E3 ubiquitin-protein ligase HERC4 isoform X11
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_047424992.1 → XP_047280948.1 probable E3 ubiquitin-protein ligase HERC4 isoform X4
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_024447927.2 → XP_024303695.1 probable E3 ubiquitin-protein ligase HERC4 isoform X1
- UniProtKB/TrEMBL
-
A8K9U4
- Conserved Domains (2) summary
-
- COG5184
Location:2 → 368
- ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
- cd00078
Location:733 → 1079
- HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
-
XM_047424993.1 → XP_047280949.1 probable E3 ubiquitin-protein ligase HERC4 isoform X4
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_047424991.1 → XP_047280947.1 probable E3 ubiquitin-protein ligase HERC4 isoform X3
- UniProtKB/Swiss-Prot
- Q5GC98, Q5GC99, Q5GCA0, Q5GLZ8, Q8IXP9, Q9HCH9
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_024447928.2 → XP_024303696.1 probable E3 ubiquitin-protein ligase HERC4 isoform X1
- UniProtKB/TrEMBL
-
A8K9U4
- Conserved Domains (2) summary
-
- COG5184
Location:2 → 368
- ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
- cd00078
Location:733 → 1079
- HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
-
XM_047424997.1 → XP_047280953.1 probable E3 ubiquitin-protein ligase HERC4 isoform X7
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_047424996.1 → XP_047280952.1 probable E3 ubiquitin-protein ligase HERC4 isoform X6
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_047424995.1 → XP_047280951.1 probable E3 ubiquitin-protein ligase HERC4 isoform X5
- UniProtKB/TrEMBL
-
A8K9U4
- Related
- ENSP00000277817.6, ENST00000277817.10
-
XM_047425001.1 → XP_047280957.1 probable E3 ubiquitin-protein ligase HERC4 isoform X12
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_047425002.1 → XP_047280958.1 probable E3 ubiquitin-protein ligase HERC4 isoform X13
Alternate T2T-CHM13v2.0
Genomic
-
NC_060934.1 Alternate T2T-CHM13v2.0
- Range
-
68790646..68944156 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054365464.1 → XP_054221439.1 probable E3 ubiquitin-protein ligase HERC4 isoform X3
- UniProtKB/Swiss-Prot
- Q5GC98, Q5GC99, Q5GCA0, Q5GLZ8, Q8IXP9, Q9HCH9
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_054365476.1 → XP_054221451.1 probable E3 ubiquitin-protein ligase HERC4 isoform X11
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_054365459.1 → XP_054221434.1 probable E3 ubiquitin-protein ligase HERC4 isoform X1
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_054365466.1 → XP_054221441.1 probable E3 ubiquitin-protein ligase HERC4 isoform X3
- UniProtKB/Swiss-Prot
- Q5GC98, Q5GC99, Q5GCA0, Q5GLZ8, Q8IXP9, Q9HCH9
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_054365460.1 → XP_054221435.1 probable E3 ubiquitin-protein ligase HERC4 isoform X1
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_054365475.1 → XP_054221450.1 probable E3 ubiquitin-protein ligase HERC4 isoform X11
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_054365474.1 → XP_054221449.1 probable E3 ubiquitin-protein ligase HERC4 isoform X10
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_054365473.1 → XP_054221448.1 probable E3 ubiquitin-protein ligase HERC4 isoform X9
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_054365472.1 → XP_054221447.1 probable E3 ubiquitin-protein ligase HERC4 isoform X8
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_054365463.1 → XP_054221438.1 probable E3 ubiquitin-protein ligase HERC4 isoform X2
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_054365458.1 → XP_054221433.1 probable E3 ubiquitin-protein ligase HERC4 isoform X1
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_054365461.1 → XP_054221436.1 probable E3 ubiquitin-protein ligase HERC4 isoform X1
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_054365462.1 → XP_054221437.1 probable E3 ubiquitin-protein ligase HERC4 isoform X1
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_054365477.1 → XP_054221452.1 probable E3 ubiquitin-protein ligase HERC4 isoform X11
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_054365465.1 → XP_054221440.1 probable E3 ubiquitin-protein ligase HERC4 isoform X3
- UniProtKB/Swiss-Prot
- Q5GC98, Q5GC99, Q5GCA0, Q5GLZ8, Q8IXP9, Q9HCH9
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_054365467.1 → XP_054221442.1 probable E3 ubiquitin-protein ligase HERC4 isoform X4
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_054365468.1 → XP_054221443.1 probable E3 ubiquitin-protein ligase HERC4 isoform X4
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_054365471.1 → XP_054221446.1 probable E3 ubiquitin-protein ligase HERC4 isoform X7
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_054365470.1 → XP_054221445.1 probable E3 ubiquitin-protein ligase HERC4 isoform X6
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_054365469.1 → XP_054221444.1 probable E3 ubiquitin-protein ligase HERC4 isoform X5
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_054365478.1 → XP_054221453.1 probable E3 ubiquitin-protein ligase HERC4 isoform X12
- UniProtKB/TrEMBL
-
A8K9U4
-
XM_054365479.1 → XP_054221454.1 probable E3 ubiquitin-protein ligase HERC4 isoform X13
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.
-
NM_001017972.1: Suppressed sequence
- Description
- NM_001017972.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.