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    PLCB4 phospholipase C beta 4 [ Homo sapiens (human) ]

    Gene ID: 5332, updated on 3-Dec-2024

    Summary

    Official Symbol
    PLCB4provided by HGNC
    Official Full Name
    phospholipase C beta 4provided by HGNC
    Primary source
    HGNC:HGNC:9059
    See related
    Ensembl:ENSG00000101333 MIM:600810; AllianceGenome:HGNC:9059
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARCND2; PI-PLC; ARCND2A; ARCND2B
    Summary
    The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]
    Expression
    Broad expression in thyroid (RPKM 7.9), salivary gland (RPKM 5.4) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PLCB4 in Genome Data Viewer
    Location:
    20p12.3-p12.2
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (9068678..9480808)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (9111633..9523716)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (9049325..9461455)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene phospholipase C beta 1 Neighboring gene Sharpr-MPRA regulatory region 2883 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:8917332-8917836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:8917837-8918339 Neighboring gene RNA, U105B small nucleolar Neighboring gene uncharacterized LOC105372522 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:9031646-9032845 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:9055836-9056336 Neighboring gene Sharpr-MPRA regulatory region 7247 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:9160877-9161492 Neighboring gene MPRA-validated peak4143 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17537 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:9496172-9496756 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:9499300-9500006 Neighboring gene uncharacterized LOC105372523 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:9553223-9553723 Neighboring gene LAMP5 antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:9557290-9557799 Neighboring gene lysosomal associated membrane protein family member 5 Neighboring gene p21 (RAC1) activated kinase 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Auriculocondylar syndrome 2
    MedGen: C3553404 OMIM: 614669 GeneReviews: Not available
    Compare labs
    Auriculocondylar syndrome 2B
    MedGen: C5830664 OMIM: 620458 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    Common variations in PSMD3-CSF3 and PLCB4 are associated with neutrophil count.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells PubMed
    Tat tat Phospholipase C/protein kinase C pathway-dependent phosphorylation of p44/42 and JNK MAP kinases is partially involved in IL-1beta induction by HIV-1 Tat PubMed
    tat HIV-1 Tat induces release of calcium and TNF-alpha production, an effect mediated at least in part by activation of phospholipase C PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ16169

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phospholipase C activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipase C-activating endothelin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
    Names
    1-phosphatidyl-D-myo-inositol-4,5-bisphosphate
    PLC-beta-4
    dJ1119D9.2 (Phopholipase C, beta 4 (1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Beta 4))
    inositoltrisphosphohydrolase
    monophosphatidylinositol phosphodiesterase
    phosphoinositidase C
    phosphoinositide phospholipase C-beta-4
    triphosphoinositide phosphodiesterase
    NP_000924.3
    NP_001166117.1
    NP_001364063.1
    NP_001364064.1
    NP_001364065.1
    NP_001364071.1
    NP_001364072.1
    NP_877949.2
    XP_005260781.1
    XP_006723632.1
    XP_011527556.1
    XP_016883373.1
    XP_024307666.1
    XP_024307668.1
    XP_047296157.1
    XP_047296158.1
    XP_047296159.1
    XP_047296160.1
    XP_047296161.1
    XP_047296162.1
    XP_054179488.1
    XP_054179489.1
    XP_054179490.1
    XP_054179491.1
    XP_054179492.1
    XP_054179493.1
    XP_054179494.1
    XP_054179495.1
    XP_054179496.1
    XP_054179497.1
    XP_054179498.1
    XP_054179499.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032790.2 RefSeqGene

      Range
      5034..416755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000933.4NP_000924.3  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a

      See identical proteins and their annotated locations for NP_000924.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon in the central coding region and includes an alternate exon in the 3' coding region that results in a frameshift, compared to variant 3. The complete exon combination of the 5' UTR for this variant has not been determined. The resulting isoform (a) lacks an internal segment and has a longer and distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AL023805, AL031652, AL121898, AL121909
      Consensus CDS
      CCDS13104.1
      UniProtKB/TrEMBL
      A0A8I5KXD7
      Related
      ENSP00000508600.1, ENST00000686976.1
      Conserved Domains (6) summary
      PTZ00121
      Location:8471194
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:702818
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312668
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:914955
      DUF1154; Protein of unknown function (DUF1154)
    2. NM_001172646.2NP_001166117.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes isoform c.
      Source sequence(s)
      AK307837, AL117633, BC143868, DB270238, DN913865
      Consensus CDS
      CCDS54447.1
      UniProtKB/TrEMBL
      A0A8I5KQZ0
      Related
      ENSP00000508676.1, ENST00000685823.1
      Conserved Domains (6) summary
      cd00275
      Location:714830
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312680
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam06631
      Location:926967
      DUF1154; Protein of unknown function (DUF1154)
      cd16211
      Location:148300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      cl26511
      Location:8511182
      Neuromodulin_N; Gap junction protein N-terminal region
    3. NM_001377134.2NP_001364063.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL023805, AL031652, AL121898, AL121909
      Consensus CDS
      CCDS13104.1
      UniProtKB/TrEMBL
      A0A8I5KXD7
      Related
      ENSP00000510118.1, ENST00000686871.1
      Conserved Domains (6) summary
      PTZ00121
      Location:8471194
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:702818
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312668
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:914955
      DUF1154; Protein of unknown function (DUF1154)
    4. NM_001377135.1NP_001364064.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL023805, AL031652, AL121898, AL121909
      Consensus CDS
      CCDS13104.1
      UniProtKB/TrEMBL
      A0A8I5KXD7
      Related
      ENSP00000508595.1, ENST00000686313.1
      Conserved Domains (6) summary
      PTZ00121
      Location:8471194
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:702818
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312668
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:914955
      DUF1154; Protein of unknown function (DUF1154)
    5. NM_001377136.1NP_001364065.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL023805, AL031652, AL121898, AL121909
      Consensus CDS
      CCDS13105.1
      UniProtKB/Swiss-Prot
      B7ZLK6, E2QRH8, Q15147, Q17R56, Q5JYS8, Q5JYS9, Q5JYT0, Q5JYT3, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2
      UniProtKB/TrEMBL
      A0A8I5KQZ0
      Related
      ENSP00000510302.1, ENST00000685859.1
      Conserved Domains (6) summary
      PTZ00121
      Location:8391170
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:702818
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312668
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:914955
      DUF1154; Protein of unknown function (DUF1154)
    6. NM_001377142.1NP_001364071.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL023805, AL031652, AL121898, AL121909
      Consensus CDS
      CCDS93005.1
      UniProtKB/TrEMBL
      A0A7P0MRI8, A0A8I5KS50
      Related
      ENSP00000367734.5, ENST00000378473.9
      Conserved Domains (6) summary
      PTZ00121
      Location:8591206
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:714830
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312680
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:926967
      DUF1154; Protein of unknown function (DUF1154)
    7. NM_001377143.1NP_001364072.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL023805, AL031652, AL121898, AL121909
      Consensus CDS
      CCDS93005.1
      UniProtKB/TrEMBL
      A0A7P0MRI8, A0A8I5KS50
      Related
      ENSP00000508726.1, ENST00000685568.1
      Conserved Domains (6) summary
      PTZ00121
      Location:8591206
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:714830
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312680
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:926967
      DUF1154; Protein of unknown function (DUF1154)
    8. NM_182797.3NP_877949.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform b

      See identical proteins and their annotated locations for NP_877949.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 3. The complete exon combination of the 5' UTR for this variant has not been determined. The resulting isoform (b) lacks an internal segment, compared to isoform c.
      Source sequence(s)
      AL023805, AL031652, AL121898, AL121909
      Consensus CDS
      CCDS13105.1
      UniProtKB/Swiss-Prot
      B7ZLK6, E2QRH8, Q15147, Q17R56, Q5JYS8, Q5JYS9, Q5JYT0, Q5JYT3, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2
      UniProtKB/TrEMBL
      A0A8I5KQZ0
      Related
      ENSP00000508650.1, ENST00000689910.1
      Conserved Domains (6) summary
      PTZ00121
      Location:8391170
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:702818
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312668
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:914955
      DUF1154; Protein of unknown function (DUF1154)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      9068678..9480808
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451898.2XP_024307666.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      A0A7P0MRI8, A0A8I5KS50
      Conserved Domains (6) summary
      PTZ00121
      Location:8591206
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:714830
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312680
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:926967
      DUF1154; Protein of unknown function (DUF1154)
    2. XM_005260724.3XP_005260781.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      See identical proteins and their annotated locations for XP_005260781.1

      UniProtKB/TrEMBL
      A0A7P0MRI8, A0A8I5KS50
      Conserved Domains (6) summary
      PTZ00121
      Location:8591206
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:714830
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312680
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:926967
      DUF1154; Protein of unknown function (DUF1154)
    3. XM_006723569.3XP_006723632.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      See identical proteins and their annotated locations for XP_006723632.1

      UniProtKB/TrEMBL
      A0A7P0MRI8, A0A8I5KS50
      Conserved Domains (6) summary
      PTZ00121
      Location:8591206
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:714830
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312680
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:926967
      DUF1154; Protein of unknown function (DUF1154)
    4. XM_024451900.2XP_024307668.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      A0A7P0MRI8, A0A8I5KS50
      Conserved Domains (6) summary
      PTZ00121
      Location:8591206
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:714830
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312680
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:926967
      DUF1154; Protein of unknown function (DUF1154)
    5. XM_047440201.1XP_047296157.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      A0A7P0MRI8, A0A8I5KS50
    6. XM_047440202.1XP_047296158.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2

      UniProtKB/TrEMBL
      A0A8I5KXD7
      Related
      ENSP00000509212.1, ENST00000492632.5
    7. XM_047440203.1XP_047296159.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      A0A7P0MRI8, A0A8I5KS50
    8. XM_047440204.1XP_047296160.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3

      UniProtKB/TrEMBL
      A0A8I5KW09
      Related
      ENSP00000508624.1, ENST00000690729.1
    9. XM_017027884.2XP_016883373.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3

      UniProtKB/TrEMBL
      A0A8I5KW09
      Conserved Domains (6) summary
      cd00275
      Location:601717
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:199567
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      pfam06631
      Location:813854
      DUF1154; Protein of unknown function (DUF1154)
      cd16211
      Location:35187
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      cl17171
      Location:130
      PH-like; Pleckstrin homology-like domain
      cl26511
      Location:7461093
      Neuromodulin_N; Gap junction protein N-terminal region
    10. XM_011529254.3XP_011527556.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X4

      UniProtKB/TrEMBL
      A0A8I5KW09
      Conserved Domains (6) summary
      cd00275
      Location:554670
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:152520
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02228
      Location:58659
      PLN02228; Phosphoinositide phospholipase C
      pfam06631
      Location:766806
      DUF1154; Protein of unknown function (DUF1154)
      pfam09279
      Location:61152
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam09728
      Location:7811018
      Taxilin; Myosin-like coiled-coil protein
    11. XM_047440205.1XP_047296161.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5

      UniProtKB/TrEMBL
      A0A8I5KW09
      Related
      ENST00000482123.1
    12. XM_047440206.1XP_047296162.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      9111633..9523716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323515.1XP_054179490.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KS50
    2. XM_054323517.1XP_054179492.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KS50
    3. XM_054323516.1XP_054179491.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KS50
    4. XM_054323518.1XP_054179493.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KS50
    5. XM_054323513.1XP_054179488.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KS50
    6. XM_054323514.1XP_054179489.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2

      UniProtKB/TrEMBL
      A0A8I5KXD7
    7. XM_054323519.1XP_054179494.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KS50
    8. XM_054323521.1XP_054179496.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3

      UniProtKB/TrEMBL
      A0A8I5KW09
    9. XM_054323520.1XP_054179495.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3

      UniProtKB/TrEMBL
      A0A8I5KW09
    10. XM_054323522.1XP_054179497.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X4

      UniProtKB/TrEMBL
      A0A8I5KW09
    11. XM_054323523.1XP_054179498.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5

      UniProtKB/TrEMBL
      A0A8I5KW09
    12. XM_054323524.1XP_054179499.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X6