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    RPL30 ribosomal protein L30 [ Homo sapiens (human) ]

    Gene ID: 6156, updated on 10-Dec-2024

    Summary

    Official Symbol
    RPL30provided by HGNC
    Official Full Name
    ribosomal protein L30provided by HGNC
    Primary source
    HGNC:HGNC:10333
    See related
    Ensembl:ENSG00000156482 MIM:180467; AllianceGenome:HGNC:10333
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L30; eL30
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30E family of ribosomal proteins. It is located in the cytoplasm. This gene is co-transcribed with the U72 small nucleolar RNA gene, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 1597.1), lymph node (RPKM 816.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See RPL30 in Genome Data Viewer
    Location:
    8q22.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (98041721..98045545, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (99167205..99171037, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (99053949..99057773, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:98880393-98880892 Neighboring gene ribosomal protein S23 pseudogene 1 Neighboring gene matrilin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:98909071-98909570 Neighboring gene uncharacterized LOC124901987 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:98962761-98963312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:98963313-98963863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:99019619-99020119 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:99023104-99023762 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_103766 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_103770 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:99044769-99045968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27672 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:99057921-99058857 Neighboring gene small nucleolar RNA, H/ACA box 72 Neighboring gene RNA, U6 small nuclear 703, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19394 Neighboring gene glutamate rich 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27676

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human 60S ribosomal protein L30 (RPL30) at amino acid residues 92-93 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    General protein information

    Preferred Names
    large ribosomal subunit protein eL30
    Names
    60S ribosomal protein L30

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000989.4 → NP_000980.1  large ribosomal subunit protein eL30

      See identical proteins and their annotated locations for NP_000980.1

      Status: REVIEWED

      Source sequence(s)
      BC095426, BM785413
      Consensus CDS
      CCDS34928.1
      UniProtKB/Swiss-Prot
      B2R591, P04645, P62888, Q502Z6
      UniProtKB/TrEMBL
      E5RI99
      Related
      ENSP00000287038.3, ENST00000287038.8
      Conserved Domains (1) summary
      PTZ00106
      Location:2 → 107
      PTZ00106; 60S ribosomal protein L30; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      98041721..98045545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      99167205..99171037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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