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    Shq1 SHQ1 homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 72171, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Shq1provided by MGI
    Official Full Name
    SHQ1 homolog (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1919421
    See related
    Ensembl:ENSMUSG00000035378 AllianceGenome:MGI:1919421
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Grim-1; 2810403P18Rik
    Summary
    Predicted to enable unfolded protein binding activity. Acts upstream of or within with a positive effect on regulation of androgen receptor signaling pathway. Acts upstream of or within positive regulation of TORC1 signaling. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in brain ventricular layer; cortical plate; olfactory epithelium; and submandibular gland primordium. Human ortholog(s) of this gene implicated in dystonia 35, childhood-onset. Orthologous to human SHQ1 (SHQ1, H/ACA ribonucleoprotein assembly factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 2.7), CNS E11.5 (RPKM 2.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Shq1 in Genome Data Viewer
    Location:
    6 D3; 6 46.82 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (100548772..100648135, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (100571811..100671183, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700049E22 gene Neighboring gene predicted gene, 33741 Neighboring gene STARR-seq mESC enhancer starr_16870 Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr6:100621045-100621346 Neighboring gene glucoside xylosyltransferase 2 Neighboring gene high mobility group box 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1325 Neighboring gene STARR-positive B cell enhancer ABC_E2197 Neighboring gene STARR-seq mESC enhancer starr_16873 Neighboring gene protein phosphatase 4, regulatory subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis. Hieronymus H, et al. Nat Commun, 2017 Oct 20. PMID 29057879, Free PMC Article
    2. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in box H/ACA snoRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in box H/ACA snoRNP assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of TORC1 signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein-RNA complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-RNA complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within_positive_effect regulation of androgen receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein SHQ1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181590.5 → NP_853621.2  protein SHQ1 homolog

      See identical proteins and their annotated locations for NP_853621.2

      Status: VALIDATED

      Source sequence(s)
      AC162389, AK012978, BY776788, CB522035, CF746515
      Consensus CDS
      CCDS39580.2
      UniProtKB/Swiss-Prot
      Q7TMX5
      Related
      ENSMUSP00000127797.2, ENSMUST00000170667.8
      Conserved Domains (3) summary
      cd00298
      Location:9 → 78
      ACD_sHsps_p23-like; This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, ...
      pfam04925
      Location:245 → 414
      SHQ1; SHQ1 protein
      cl21457
      Location:179 → 266
      TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      100548772..100648135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506669.5 → XP_006506732.1  protein SHQ1 homolog isoform X2

      UniProtKB/Swiss-Prot
      Q7TMX5
      Related
      ENSMUSP00000086656.7, ENSMUST00000089245.7
      Conserved Domains (2) summary
      cd00298
      Location:9 → 78
      ACD_sHsps_p23-like; This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, ...
      pfam04925
      Location:244 → 305
      SHQ1; SHQ1 protein

    2. XM_006506668.5 → XP_006506731.1  protein SHQ1 homolog isoform X1

      Conserved Domains (3) summary
      cd00298
      Location:9 → 78
      ACD_sHsps_p23-like; This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, ...
      pfam04925
      Location:245 → 407
      SHQ1; SHQ1 protein
      cl21457
      Location:179 → 266
      TIM; TIM-like beta/alpha barrel domains

    3. XM_006506670.5 → XP_006506733.1  protein SHQ1 homolog isoform X3

      Conserved Domains (3) summary
      cd00298
      Location:9 → 78
      ACD_sHsps_p23-like; This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, ...
      pfam04925
      Location:245 → 358
      SHQ1; SHQ1 protein
      cl21457
      Location:179 → 266
      TIM; TIM-like beta/alpha barrel domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TMX5.2 GenPept UniProtKB/Swiss-Prot:Q7TMX5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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