Rarres1 retinoic acid receptor responder (tazarotene induced) 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rarres1provided by MGI
Official Full Name: retinoic acid receptor responder (tazarotene induced) 1provided by MGI
Primary source: MGI:MGI:1924461
See related: Ensembl:ENSMUSG00000049404 AllianceGenome:MGI:1924461
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5430417P09Rik
Summary: Predicted to enable metalloendopeptidase inhibitor activity. Predicted to be active in extracellular space. Used to study follicular lymphoma. Orthologous to human RARRES1 (retinoic acid receptor responder 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver adult (RPKM 15.1), genital fat pad adult (RPKM 3.4) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 E1; 3 30.99 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (67386219..67422856, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (67478886..67515523, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Podocyte-derived soluble RARRES1 drives kidney disease progression through direct podocyte and proximal tubular injury.
Title: Podocyte-derived soluble RARRES1 drives kidney disease progression through direct podocyte and proximal tubular injury.
Loss of RARRES1 function Promotes Follicular Lymphomagenesis and Inhibits B cell Differentiation in Mice.
Title: Loss of RARRES1 function Promotes Follicular Lymphomagenesis and Inhibits B cell Differentiation in Mice.
Retinoic acid receptor responder1 promotes development of glomerular diseases via the Nuclear Factor-kappaB signaling pathway.
Title: Retinoic acid receptor responder1 promotes development of glomerular diseases via the Nuclear Factor-κB signaling pathway.
Soluble RARRES1 induces podocyte apoptosis to promote glomerular disease progression.
Title: Soluble RARRES1 induces podocyte apoptosis to promote glomerular disease progression.
RARRES1 and 2 may have different expression and roles in human and rodent placentas, thereby underlining immanent limitations of comparative interspecies placentology.
Title: Expression of Retinoid Acid Receptor-Responsive Genes in Rodent Models of Placental Pathology.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (6) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metalloendopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: retinoic acid receptor responder protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164763.1 → NP_001158235.1 retinoic acid receptor responder protein 1 precursor

Status: VALIDATED

Source sequence(s)

AC124190, AK077393, AV243667

Consensus CDS

CCDS57216.1

UniProtKB/TrEMBL

F6ZIS7, Q8BVL6

Related

ENSMUSP00000056728.6, ENSMUST00000054825.5

Conserved Domains (1) summary

pfam06907
Location:45 → 263

Latexin; Latexin