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    Sac3d1 SAC3 domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 66406, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sac3d1provided by MGI
    Official Full Name
    SAC3 domain containing 1provided by MGI
    Primary source
    MGI:MGI:1913656
    See related
    Ensembl:ENSMUSG00000024790 AllianceGenome:MGI:1913656
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    shd1; 2410004C24Rik
    Summary
    Acts upstream of or within microtubule cytoskeleton organization; negative regulation of receptor signaling pathway via JAK-STAT; and regulation of immune response. Located in centrosome; nucleus; and spindle. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human SAC3D1 (SAC3 domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 50.3), adrenal adult (RPKM 46.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sac3d1 in Genome Data Viewer
    Location:
    19 A; 19 4.34 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6166025..6168689, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6116004..6118586, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene 550 Neighboring gene N-acetylated alpha-linked acidic dipeptidase-like 1 Neighboring gene STARR-seq mESC enhancer starr_45420 Neighboring gene sorting nexin 15 Neighboring gene STARR-positive B cell enhancer ABC_E11014 Neighboring gene predicted gene, 57660 Neighboring gene microRNA 12193 Neighboring gene ADP-ribosylation factor-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Sac3 homologue shd1 is involved in mitotic progression in mammalian cells. Khuda SE, et al. J Biol Chem, 2004 Oct 29. PMID 15322101
    2. SHD1 is a novel cytokine-inducible, negative feedback regulator of STAT5-dependent transcription. Nakajima H, et al. Blood, 2009 Jan 29. PMID 18838617
    3. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SHD1 is a novel cytokine-inducible negative feedback regulator of STAT5a.
      Title: SHD1 is a novel cytokine-inducible, negative feedback regulator of STAT5-dependent transcription.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centrosome duplication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SAC3 domain-containing protein 1
    Names
    SAC3 homology domain-containing protein 1
    Sac3 homology domain 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133678.3 → NP_598439.3  SAC3 domain-containing protein 1

      See identical proteins and their annotated locations for NP_598439.3

      Status: VALIDATED

      Source sequence(s)
      AK075930, BI134670
      Consensus CDS
      CCDS37896.1
      UniProtKB/Swiss-Prot
      A6H687, B7ZMU9, Q8BVY1, Q9QXE1
      UniProtKB/TrEMBL
      G5E8Q7
      Related
      ENSMUSP00000109161.2, ENSMUST00000113533.3
      Conserved Domains (1) summary
      pfam03399
      Location:150 → 356
      SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6166025..6168689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161651.1 → XP_036017544.1  SAC3 domain-containing protein 1 isoform X1

      Conserved Domains (1) summary
      cl24019
      Location:81 → 266
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6H687.1 GenPept UniProtKB/Swiss-Prot:A6H687

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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