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    Ppp1r2 protein phosphatase 1, regulatory inhibitor subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 66849, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ppp1r2provided by MGI
    Official Full Name
    protein phosphatase 1, regulatory inhibitor subunit 2provided by MGI
    Primary source
    MGI:MGI:1914099
    See related
    Ensembl:ENSMUSG00000047714 AllianceGenome:MGI:1914099
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    I-2; IPP-2; D16Ertd248e; 0610025N14Rik; 2310007G06Rik; 4930440J04Rik; 5430408E15Rik
    Summary
    Enables molecular function inhibitor activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in dendritic spine and growth cone. Is expressed in several structures, including branchial arch; cranial ganglion; dorsal root ganglion; forelimb bud; and sensory organ. Orthologous to several human genes including PPP1R2 (protein phosphatase 1 regulatory inhibitor subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 46.0), lung adult (RPKM 45.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ppp1r2 in Genome Data Viewer
    Location:
    16 B2; 16 21.41 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (31070359..31094095, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (31251541..31275277, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 Neighboring gene zinc finger protein 161 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40608 Neighboring gene STARR-positive B cell enhancer ABC_E4163 Neighboring gene STARR-positive B cell enhancer ABC_E7438 Neighboring gene predicted gene, 52237 Neighboring gene predicted gene, 41442 Neighboring gene STARR-seq mESC enhancer starr_40609 Neighboring gene STARR-seq mESC enhancer starr_40611 Neighboring gene predicted gene, 49767 Neighboring gene apolipoprotein D

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular function inhibitor activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables molecular function inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein phosphatase inhibitor 2
    NP_080076.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025800.3NP_080076.1  protein phosphatase inhibitor 2

      See identical proteins and their annotated locations for NP_080076.1

      Status: VALIDATED

      Source sequence(s)
      AI573352, AK053657, AK150281
      Consensus CDS
      CCDS28104.1
      UniProtKB/Swiss-Prot
      Q3UD25, Q8C1A6, Q9DCL8
      UniProtKB/TrEMBL
      Q8BVM6
      Related
      ENSMUSP00000060118.8, ENSMUST00000060188.14
      Conserved Domains (1) summary
      pfam04979
      Location:46165
      IPP-2; Protein phosphatase inhibitor 2 (IPP-2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      31070359..31094095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)