Shisa6 shisa family member 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Shisa6provided by MGI
Official Full Name: shisa family member 6provided by MGI
Primary source: MGI:MGI:2685725
See related: Ensembl:ENSMUSG00000053930 AllianceGenome:MGI:2685725
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm879; ckamp52
Summary: Enables PDZ domain binding activity and ionotropic glutamate receptor binding activity. Involved in several processes, including excitatory chemical synaptic transmission; postsynaptic neurotransmitter receptor diffusion trapping; and regulation of signal transduction. Located in asymmetric, glutamatergic, excitatory synapse and postsynaptic density. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in central nervous system and testis. Orthologous to human SHISA6 (shisa family member 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 10.0), CNS E18 (RPKM 3.4) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 40.55 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (66102551..66418715, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (66211725..66527984, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AMPAR Auxiliary Protein SHISA6 Facilitates Purkinje Cell Synaptic Excitability and Procedural Memory Formation.
Title: AMPAR Auxiliary Protein SHISA6 Facilitates Purkinje Cell Synaptic Excitability and Procedural Memory Formation.
This study proposes a generic mechanism of stem cell regulation in a facultative (or open) niche environment, with which different levels of a cell-autonomous inhibitor (SHISA6, in this case) generates heterogeneous resistance to widely distributed differentiation-promoting extracellular signaling, such as WNTs.
Title: SHISA6 Confers Resistance to Differentiation-Promoting Wnt/β-Catenin Signaling in Mouse Spermatogenic Stem Cells.
This study indicates that AMPAR function is very precisely controlled by the cell-type specific expression of the CKAMP family members 39, 52 and 59.
Title: Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties.
Shisa6 prevents synaptically trapped AMPARs from depression at high-frequency synaptic transmission.
Title: Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Mit193 (e-PCR), detects polymorphism
- UniSTS:126390

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables ionotropic glutamate receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ionotropic glutamate receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in excitatory chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic neurotransmitter receptor diffusion trapping	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic neurotransmitter receptor diffusion trapping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of AMPA glutamate receptor clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic neurotransmitter receptor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of short-term neuronal synaptic plasticity	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of AMPA glutamate receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in asymmetric, glutamatergic, excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendritic spine membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IEP Inferred from Expression Pattern more info	PubMed
is_active_in postsynaptic density membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein shisa-6

Names: cysteine-knot AMPAR-modulating protein 52; cystine-knot AMPAR modulating protein of 52 kDa; protein shisa-6 homolog; shisa homolog 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034874.4 → NP_001030046.1 protein shisa-6 isoform 2 precursor

See identical proteins and their annotated locations for NP_001030046.1

Status: VALIDATED

Source sequence(s)

AL663051, AL663083

Consensus CDS

CCDS24848.1

UniProtKB/Swiss-Prot

A0A172Q417, Q3UH99

UniProtKB/TrEMBL

F6VQZ6

Related

ENSMUSP00000071025.7, ENSMUST00000066679.7

Conserved Domains (1) summary

pfam13908
Location:97 → 264

Shisa; Wnt and FGF inhibitory regulator
NM_001415764.1 → NP_001402693.1 protein shisa-6 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL663051, AL663083

Related

ENSMUSP00000120862.2, ENSMUST00000123454.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

66102551..66418715 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246098.2 → XP_030101958.1 protein shisa-6 isoform X1

UniProtKB/TrEMBL

F6VQZ6

Conserved Domains (1) summary

pfam13908
Location:97 → 276

Shisa; Wnt and FGF inhibitory regulator
XM_036156815.1 → XP_036012708.1 protein shisa-6 isoform X2

UniProtKB/Swiss-Prot

A0A172Q417, Q3UH99

UniProtKB/TrEMBL

F6VQZ6

Conserved Domains (1) summary

pfam13908
Location:97 → 264

Shisa; Wnt and FGF inhibitory regulator
XM_006533619.5 → XP_006533682.1 protein shisa-6 isoform X1

UniProtKB/TrEMBL

F6VQZ6

Conserved Domains (1) summary

pfam13908
Location:97 → 276

Shisa; Wnt and FGF inhibitory regulator