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    Morn2 MORN repeat containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 378462, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Morn2provided by MGI
    Official Full Name
    MORN repeat containing 2provided by MGI
    Primary source
    MGI:MGI:2674071
    See related
    Ensembl:ENSMUSG00000045257 AllianceGenome:MGI:2674071
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mopt
    Summary
    Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in acrosomal vesicle and nucleus. Orthologous to human MORN2 (MORN repeat containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 89.9), kidney adult (RPKM 7.0) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Morn2 in Genome Data Viewer
    Location:
    17 E3; 17 50.63 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (80597626..80613130)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (80290203..80300096)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7559 Neighboring gene STARR-positive B cell enhancer ABC_E5631 Neighboring gene gem nuclear organelle associated protein 6 Neighboring gene STARR-positive B cell enhancer ABC_E3217 Neighboring gene STARR-positive B cell enhancer ABC_E5632 Neighboring gene tetratricopeptide repeat domain 39D Neighboring gene STARR-seq mESC enhancer starr_43307 Neighboring gene STARR-seq mESC enhancer starr_43308 Neighboring gene DExH-box helicase 57 Neighboring gene STARR-positive B cell enhancer ABC_E7560 Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene STARR-seq mESC enhancer starr_43309 Neighboring gene STARR-seq mESC enhancer starr_43310 Neighboring gene predicted gene 10190 Neighboring gene STARR-seq mESC enhancer starr_43312 Neighboring gene SOS Ras/Rac guanine nucleotide exchange factor 1 Neighboring gene STARR-seq mESC enhancer starr_43313 Neighboring gene ribosomal protein L17 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MORN2 regulates the morphology and energy metabolism of mitochondria and is required for male fertility in mice. Liu Y, et al. J Transl Med, 2024 Mar 5. PMID 38443933, Free PMC Article
    2. Identification and characterization of a novel mouse and human MOPT gene containing MORN-motif protein in testis. Choi YJ, et al. Theriogenology, 2010 Feb. PMID 19913896
    3. Characterization of MORN2 stability and regulatory function in LC3-associated phagocytosis in macrophages. Morita M, et al. Biol Open, 2020 Jun 23. PMID 32414768, Free PMC Article
    4. Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase. Strong ER, et al. Genes (Basel), 2010 Dec 2. PMID 21779533, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MORN2 regulates the morphology and energy metabolism of mitochondria and is required for male fertility in mice.
      Title: MORN2 regulates the morphology and energy metabolism of mitochondria and is required for male fertility in mice.
    2. Characterization of MORN2 stability and regulatory function in LC3-associated phagocytosis in macrophages.
      Title: Characterization of MORN2 stability and regulatory function in LC3-associated phagocytosis in macrophages.
    3. MOPT is associated with dynamic regulation of acrosome biogenesis during late spermiogenesis.
      Title: Identification and characterization of a novel mouse and human MOPT gene containing MORN-motif protein in testis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC107136

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MORN repeat-containing protein 2
    Names
    MORN motif protein in testis
    protein containing single MORN motif in testis

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360440.2 → NP_001347369.1  MORN repeat-containing protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC132910
      Consensus CDS
      CCDS37703.1
      UniProtKB/Swiss-Prot
      Q6UL01
      Conserved Domains (1) summary
      COG4642
      Location:1 → 72
      COG4642; Uncharacterized conserved protein [Function unknown]

    2. NM_001413767.1 → NP_001400696.1  MORN repeat-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132910
      UniProtKB/Swiss-Prot
      Q6UL01

    3. NM_001433551.1 → NP_001420480.1  MORN repeat-containing protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132910
      UniProtKB/TrEMBL
      A0A2I3BRK9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      80597626..80613130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160655.1 → XP_036016548.1  MORN repeat-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6UL01
      Conserved Domains (1) summary
      COG4642
      Location:1 → 72
      COG4642; Uncharacterized conserved protein [Function unknown]

    2. XM_036160656.1 → XP_036016549.1  MORN repeat-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6UL01
      Conserved Domains (1) summary
      COG4642
      Location:1 → 72
      COG4642; Uncharacterized conserved protein [Function unknown]

    3. XM_036160654.1 → XP_036016547.1  MORN repeat-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6UL01
      Conserved Domains (1) summary
      COG4642
      Location:1 → 72
      COG4642; Uncharacterized conserved protein [Function unknown]

    4. XM_036160657.1 → XP_036016550.1  MORN repeat-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6UL01
      Conserved Domains (1) summary
      COG4642
      Location:1 → 72
      COG4642; Uncharacterized conserved protein [Function unknown]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_194269.3: Suppressed sequence

      Description
      NM_194269.3: This RefSeq was removed by NCBI staff.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UL01.1 GenPept UniProtKB/Swiss-Prot:Q6UL01

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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