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    Ppp1r17 protein phosphatase 1, regulatory subunit 17 [ Mus musculus (house mouse) ]

    Gene ID: 19051, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ppp1r17provided by MGI
    Official Full Name
    protein phosphatase 1, regulatory subunit 17provided by MGI
    Primary source
    MGI:MGI:1333876
    See related
    Ensembl:ENSMUSG00000002930 AllianceGenome:MGI:1333876
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gsbs; Ppp1r2
    Summary
    Enables protein serine/threonine phosphatase inhibitor activity. Involved in regulation of phosphatase activity. Predicted to be located in cytosol. Is expressed in alimentary system; cerebellum; ganglia; heart; and neural retina. Human ortholog(s) of this gene implicated in familial hypercholesterolemia. Orthologous to human PPP1R17 (protein phosphatase 1 regulatory subunit 17). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 38.8) and CNS E11.5 (RPKM 4.9) See more
    Orthologs
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    Genomic context

    See Ppp1r17 in Genome Data Viewer
    Location:
    6 B3; 6 27.65 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (55994482..56009674)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (56017497..56032689)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15981 Neighboring gene STARR-seq mESC enhancer starr_15982 Neighboring gene predicted gene, 38820 Neighboring gene ITPR interacting domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_15983 Neighboring gene STARR-seq mESC enhancer starr_15984 Neighboring gene STARR-seq mESC enhancer starr_15985 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene phosphodiesterase 1C Neighboring gene STARR-seq mESC enhancer starr_15986 Neighboring gene STARR-positive B cell enhancer mm9_chr6:56183581-56183882 Neighboring gene STARR-seq mESC enhancer starr_15987 Neighboring gene STARR-seq mESC enhancer starr_15988 Neighboring gene predicted gene, 34753

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    protein phosphatase 1 regulatory subunit 17
    Names
    G substrate
    protein phosphatase 1, regulatory (inhibitor) 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011153.4NP_035283.1  protein phosphatase 1 regulatory subunit 17

      See identical proteins and their annotated locations for NP_035283.1

      Status: VALIDATED

      Source sequence(s)
      AC079365
      Consensus CDS
      CCDS20169.1
      UniProtKB/Swiss-Prot
      Q9Z2E4
      Related
      ENSMUSP00000059708.5, ENSMUST00000052827.6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      55994482..56009674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)