Poln DNA polymerase N [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Polnprovided by MGI
Official Full Name: DNA polymerase Nprovided by MGI
Primary source: MGI:MGI:2675617
See related: Ensembl:ENSMUSG00000045102 AllianceGenome:MGI:2675617
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: POL4P
Summary: Predicted to enable DNA-directed DNA polymerase activity and cyclin binding activity. Predicted to be involved in double-strand break repair via homologous recombination; interstrand cross-link repair; and translesion synthesis. Predicted to act upstream of or within DNA-templated DNA replication. Predicted to be located in nucleoplasm. Is expressed in stomach and testis. Orthologous to human POLN (DNA polymerase nu). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 3.7), CNS E11.5 (RPKM 2.7) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B2; 5 17.83 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (34164523..34326870, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (34007179..34169526, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inactivation of Poln in mouse embryonic fibroblasts did not alter cellular sensitivity to mitomycin C, cisplatin, or aldehydes. Pol nu-defective mice had no alteration in DNA end-joining during immunoglobulin class-switching.
Title: Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance.
identification as homolog to Mus308
Title: POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF403055 (e-PCR)
- UniSTS:246283

RH138893 (e-PCR)
- UniSTS:220980

D5Jcs46 (e-PCR), detects polymorphism
- UniSTS:478882

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed DNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-directed DNA polymerase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables cyclin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA-templated DNA replication	ISO Inferred from Sequence Orthology more info	PubMed
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in interstrand cross-link repair	ISO Inferred from Sequence Orthology more info
involved_in translesion synthesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: DNA polymerase nu

Names: DNA-directed DNA polymerase nu

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.