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    Tmem131l transmembrane 131 like [ Mus musculus (house mouse) ]

    Gene ID: 229473, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem131lprovided by MGI
    Official Full Name
    transmembrane 131 likeprovided by MGI
    Primary source
    MGI:MGI:2443399
    See related
    Ensembl:ENSMUSG00000033767 AllianceGenome:MGI:2443399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kiaa0922; mKIAA0922; D930015E06Rik
    Summary
    Predicted to be involved in negative regulation of canonical Wnt signaling pathway and negative regulation of immature T cell proliferation in thymus. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human TMEM131L (transmembrane 131 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in thymus adult (RPKM 30.1), whole brain E14.5 (RPKM 27.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem131l in Genome Data Viewer
    Location:
    3 F1; 3 37.42 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (83804955..83947497, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (83898205..84040190, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 175 pseudogene Neighboring gene toll-like receptor 2 Neighboring gene STARR-seq mESC enhancer starr_08062 Neighboring gene STARR-seq mESC enhancer starr_08063 Neighboring gene STARR-seq mESC enhancer starr_08065 Neighboring gene STARR-positive B cell enhancer ABC_E518 Neighboring gene STARR-positive B cell enhancer ABC_E4548 Neighboring gene predicted gene, 30352 Neighboring gene predicted gene, 30458

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential gene expression during terminal erythroid differentiation. Koury S, et al. Genomics, 2007 Nov. PMID 17764892, Free PMC Article
    2. Regulatory pathway analysis by high-throughput in situ hybridization. Visel A, et al. PLoS Genet, 2007 Oct. PMID 17953485, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of immature T cell proliferation in thymus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of immature T cell proliferation in thymus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 131-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399526.1 → NP_001386455.1  transmembrane protein 131-like isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102289, AC133160, AC154875

    2. NM_172681.5 → NP_766269.3  transmembrane protein 131-like isoform 1 precursor

      See identical proteins and their annotated locations for NP_766269.3

      Status: VALIDATED

      Source sequence(s)
      AC102289, AC133160, AC154875
      Consensus CDS
      CCDS38463.1
      UniProtKB/Swiss-Prot
      Q3U3D7, Q6P5E2, Q6PHM5, Q6ZQ24, Q8C2B9, Q8K2U7, Q8R3Y2, Q8R580
      Related
      ENSMUSP00000141438.2, ENSMUST00000191758.6
      Conserved Domains (1) summary
      cl13764
      Location:91 → 174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      83804955..83947497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163039.1 → XP_036018932.1  transmembrane protein 131-like isoform X7

      Conserved Domains (1) summary
      cl13764
      Location:91 → 174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    2. XM_006501326.4 → XP_006501389.1  transmembrane protein 131-like isoform X5

      UniProtKB/TrEMBL
      A0A0B4J1F5
      Related
      ENSMUSP00000049808.9, ENSMUST00000052342.9
      Conserved Domains (2) summary
      pfam06070
      Location:1170 → 1520
      Herpes_UL32; Herpesvirus large structural phosphoprotein UL32
      cl13764
      Location:91 → 174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    3. XM_036163038.1 → XP_036018931.1  transmembrane protein 131-like isoform X3

      Conserved Domains (1) summary
      cl13764
      Location:91 → 174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    4. XM_006501323.3 → XP_006501386.1  transmembrane protein 131-like isoform X1

      Conserved Domains (1) summary
      cl13764
      Location:91 → 174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    5. XM_006501327.3 → XP_006501390.1  transmembrane protein 131-like isoform X6

      Related
      ENSMUSP00000141607.2, ENSMUST00000192095.6
      Conserved Domains (2) summary
      pfam06070
      Location:1189 → 1520
      Herpes_UL32; Herpesvirus large structural phosphoprotein UL32
      cl13764
      Location:91 → 174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    6. XM_006501325.2 → XP_006501388.1  transmembrane protein 131-like isoform X4

      UniProtKB/Swiss-Prot
      Q3U3D7
      Conserved Domains (2) summary
      pfam06070
      Location:1189 → 1521
      Herpes_UL32; Herpesvirus large structural phosphoprotein UL32
      cl13764
      Location:91 → 174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    7. XM_006501324.3 → XP_006501387.1  transmembrane protein 131-like isoform X2

      Conserved Domains (1) summary
      cl13764
      Location:91 → 174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U3D7.1 GenPept UniProtKB/Swiss-Prot:Q3U3D7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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