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    Meis2 Meis homeobox 2 [ Mus musculus (house mouse) ]

    Gene ID: 17536, updated on 9-Dec-2024

    Summary

    Official Symbol
    Meis2provided by MGI
    Official Full Name
    Meis homeobox 2provided by MGI
    Primary source
    MGI:MGI:108564
    See related
    Ensembl:ENSMUSG00000027210 AllianceGenome:MGI:108564
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mrg1; Stra10; A430109D20Rik
    Summary
    This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcriptional regulators and several members have been shown to be essential contributors to developmental programs. In mice, a knock-out of this gene leads to lethality at embryonic day 14, accompanied with hemorrhaging. Embryos lacking this gene show defects in tissues derived from the neural crest, suggesting a critical role of this gene during cranial and cardiac neural crest cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
    Expression
    Broad expression in frontal lobe adult (RPKM 31.3), CNS E14 (RPKM 21.9) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Meis2 in Genome Data Viewer
    Location:
    2 E4- E5; 2 58.28 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (115691745..115897925, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (115861264..116067537, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CDAN1 interacting nuclease 1 Neighboring gene predicted gene, 52524 Neighboring gene predicted gene, 31590 Neighboring gene STARR-seq mESC enhancer starr_05429 Neighboring gene STARR-seq mESC enhancer starr_05430 Neighboring gene RIKEN cDNA G630016G05 gene Neighboring gene RIKEN cDNA 2810405F15 gene Neighboring gene STARR-seq mESC enhancer starr_05431 Neighboring gene predicted gene, 57693

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in embryonic pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in eye development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within eye development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of myeloid cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in pancreas development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cardiac muscle myoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cardiac muscle myoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to growth factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    homeobox protein Meis2
    Names
    Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2
    meis1-related protein 1
    myeloid ecotropic viral integration site-related gene 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136072.2NP_001129544.1  homeobox protein Meis2 isoform 1

      See identical proteins and their annotated locations for NP_001129544.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' and 3' UTRs and has multiple differences in the coding region, compared to variant 9. The encoded isoform (1) is shorter and has distinct N- and C-termini compared to isoform 9.
      Source sequence(s)
      AK146633, AL929037
      Consensus CDS
      CCDS50666.1
      UniProtKB/TrEMBL
      Q3TY73, Q3UJ35
      Related
      ENSMUSP00000106533.3, ENSMUST00000110908.9
      Conserved Domains (2) summary
      pfam05920
      Location:294333
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:110194
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    2. NM_001159567.1NP_001153039.1  homeobox protein Meis2 isoform 3

      See identical proteins and their annotated locations for NP_001153039.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' UTRs and has multiple differences in the coding region, compared to variant 9. The encoded isoform (3) is shorter and has distinct N- and C-termini compared to isoform 9.
      Source sequence(s)
      AK146633, AK158839, AL929037
      Consensus CDS
      CCDS50668.1
      UniProtKB/TrEMBL
      Q3TY73
      Related
      ENSMUSP00000106532.2, ENSMUST00000110907.8
      Conserved Domains (2) summary
      pfam05920
      Location:294333
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:110194
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    3. NM_001159568.1NP_001153040.1  homeobox protein Meis2 isoform 4

      See identical proteins and their annotated locations for NP_001153040.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, and has multiple differences in the coding region, compared to variant 9. The encoded isoform (4) is shorter and has a distinct N-terminus compared to isoform 9.
      Source sequence(s)
      AK146633, AL929037, CX568764
      Consensus CDS
      CCDS50667.1
      UniProtKB/Swiss-Prot
      O35676, O35677, P97367, P97403, P97404
      UniProtKB/TrEMBL
      Q3TY73
      Related
      ENSMUSP00000028639.7, ENSMUST00000028639.13
      Conserved Domains (2) summary
      pfam05920
      Location:294333
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:110194
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    4. NM_001159569.2NP_001153041.1  homeobox protein Meis2 isoform 5

      See identical proteins and their annotated locations for NP_001153041.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has multiple differences in the coding region and differs in the 3' UTR, compared to variant 9. The encoded isoform (5) is shorter and has a distinct C-terminus compared to isoform 9.
      Source sequence(s)
      AK146633, AK158839, AL929037, CJ143034
      Consensus CDS
      CCDS50665.1
      UniProtKB/TrEMBL
      B1AWK4, Q3TY73
      Related
      ENSMUSP00000106531.3, ENSMUST00000110906.9
      Conserved Domains (2) summary
      pfam05920
      Location:293332
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:109193
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    5. NM_001159570.2NP_001153042.1  homeobox protein Meis2 isoform 6

      See identical proteins and their annotated locations for NP_001153042.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has multiple differences in the coding region and differs in the 3' UTR, compared to variant 9. The encoded isoform (6) is shorter and has a distinct C-terminus compared to isoform 9.
      Source sequence(s)
      AK146633, AK158839, AL929037, CJ143034
      Consensus CDS
      CCDS50664.1
      UniProtKB/TrEMBL
      Q3TY73, Q3TYM2
      Related
      ENSMUSP00000073898.7, ENSMUST00000074285.8
      Conserved Domains (2) summary
      pfam05920
      Location:293332
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:109193
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    6. NM_001346036.1NP_001332965.1  homeobox protein Meis2 isoform 9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) encodes the longest isoform (9).
      Source sequence(s)
      AK146633, AK158839, AL772135, AL929037, BB612458, BQ572308, CX568764
      UniProtKB/TrEMBL
      Q3TY73, Q3UJ35
    7. NM_001346038.1NP_001332967.1  homeobox protein Meis2 isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) lacks an alternate exon in the coding region, compared to variant 9. The encoded isoform (10) is shorter than isoform 9.
      Source sequence(s)
      AK146633, AK158839, AL772135, AL929037, BB612458, CX568764
      UniProtKB/TrEMBL
      Q3TY73
      Conserved Domains (2) summary
      pfam05920
      Location:293332
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:109193
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    8. NM_001346041.1NP_001332970.1  homeobox protein Meis2 isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) has multiple differences in the coding region, compared to variant 9. The encoded isoform (11) is shorter than isoform 9.
      Source sequence(s)
      AK146633, AK158839, AL772135, AL929037, BB612458, KM974644
      UniProtKB/TrEMBL
      Q3TY73
      Conserved Domains (2) summary
      pfam05920
      Location:293332
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:109193
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    9. NM_001346044.1NP_001332973.1  homeobox protein Meis2 isoform 12

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) has multiple differences in the coding region and differs in the 3' UTR, compared to variant 9. The encoded isoform (12) is shorter and has a distinct C-terminus, compared to isoform 9.
      Source sequence(s)
      AK146633, AK158839, AL772135, AL929037, BB612458, BQ572308
      UniProtKB/TrEMBL
      Q3TY73
    10. NM_001346045.1NP_001332974.1  homeobox protein Meis2 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' and 3' UTRs and has multiple differences in the coding region, compared to variant 9. The encoded isoform (7) is shorter and has distinct N- and C-termini compared to isoform 9.
      Source sequence(s)
      AK146633, AL772135, AL929037, BQ572308
      UniProtKB/TrEMBL
      Q3TY73
    11. NM_001346047.1NP_001332976.1  homeobox protein Meis2 isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' and 3' UTRs and has multiple differences in the coding region, compared to variant 9. The encoded isoform (8) is shorter and has distinct N- and C-termini compared to isoform 9.
      Source sequence(s)
      AK012325, AK146633, AK158839, AL772135, AL929037, BY012436
      UniProtKB/TrEMBL
      Q3TY73
      Conserved Domains (2) summary
      pfam05920
      Location:313352
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:129213
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    12. NM_001346053.1NP_001332982.1  homeobox protein Meis2 isoform 13

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) differs in the 5' and 3' UTRs and has multiple differences in the coding region, compared to variant 9. The encoded isoform (13) is shorter and has distinct N- and C-termini compared to isoform 9. Variants 13 and 14 encode the same isoform (13).
      Source sequence(s)
      AK146633, AK158839, AL929037, BY290986
      UniProtKB/TrEMBL
      A0A0A7EPH8
    13. NM_001346055.1NP_001332984.1  homeobox protein Meis2 isoform 13

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR, uses a downstream start codon, has multiple differences in the coding region and differs in the 3' UTR, compared to variant 9. The encoded isoform (13) is shorter and has distinct N- and C-termini compared to isoform 9. Variants 13 and 14 encode the same isoform (13).
      Source sequence(s)
      AK146633, AK158839, AL929037, BY290986, CJ143034
      UniProtKB/TrEMBL
      A0A0A7EPH8
    14. NM_001346056.1NP_001332985.1  homeobox protein Meis2 isoform 15

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) differs in the 5' and 3' UTRs and has multiple differences in the coding region, compared to variant 9. The encoded isoform (15) is shorter and has distinct N- and C-termini compared to isoform 9.
      Source sequence(s)
      AK146633, AL929037, BY290986
      UniProtKB/TrEMBL
      A0A0A7EPH8
      Conserved Domains (2) summary
      pfam05920
      Location:206245
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:22106
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    15. NM_010825.3NP_034955.1  homeobox protein Meis2 isoform 2

      See identical proteins and their annotated locations for NP_034955.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, and has multiple differences in the coding region, compared to variant 9. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 9.
      Source sequence(s)
      AK146633, AL929037, KM974644
      Consensus CDS
      CCDS16568.1
      UniProtKB/TrEMBL
      Q3TY73, Q6GU28
      Related
      ENSMUSP00000099597.4, ENSMUST00000102538.11
      Conserved Domains (2) summary
      pfam05920
      Location:294333
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:110194
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      115691745..115897925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159069.1XP_036014962.1  homeobox protein Meis2 isoform X12

      Conserved Domains (2) summary
      pfam05920
      Location:148187
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:148
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    2. XM_036159067.1XP_036014960.1  homeobox protein Meis2 isoform X11

      Conserved Domains (2) summary
      pfam05920
      Location:148187
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:148
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    3. XM_030248227.2XP_030104087.1  homeobox protein Meis2 isoform X13

      Conserved Domains (2) summary
      pfam05920
      Location:148187
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:148
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    4. XM_036159066.1XP_036014959.1  homeobox protein Meis2 isoform X10

      Conserved Domains (2) summary
      pfam05920
      Location:211250
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:148
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    5. XM_030248221.2XP_030104081.1  homeobox protein Meis2 isoform X5

      Conserved Domains (2) summary
      pfam05920
      Location:313352
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:129213
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    6. XM_006498871.5XP_006498934.1  homeobox protein Meis2 isoform X9

      See identical proteins and their annotated locations for XP_006498934.1

      UniProtKB/TrEMBL
      Q3TY73
      Conserved Domains (2) summary
      pfam05920
      Location:313352
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:129213
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    7. XM_030248224.2XP_030104084.1  homeobox protein Meis2 isoform X9

      UniProtKB/TrEMBL
      Q3TY73
      Conserved Domains (2) summary
      pfam05920
      Location:313352
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:129213
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    8. XM_036159058.1XP_036014951.1  homeobox protein Meis2 isoform X4

      Conserved Domains (2) summary
      pfam05920
      Location:313352
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:129213
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    9. XM_036159055.1XP_036014948.1  homeobox protein Meis2 isoform X2

      Conserved Domains (2) summary
      pfam05920
      Location:376415
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:129213
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    10. XM_036159064.1XP_036014957.1  homeobox protein Meis2 isoform X7

      UniProtKB/TrEMBL
      Q3TY73
      Conserved Domains (2) summary
      pfam05920
      Location:376415
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:129213
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    11. XM_011239337.4XP_011237639.1  homeobox protein Meis2 isoform X1

      See identical proteins and their annotated locations for XP_011237639.1

      Conserved Domains (2) summary
      pfam05920
      Location:376415
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:129213
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    12. XM_036159061.1XP_036014954.1  homeobox protein Meis2 isoform X6

      UniProtKB/TrEMBL
      Q3TY73
      Conserved Domains (2) summary
      pfam05920
      Location:376415
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:129213
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    13. XM_036159065.1XP_036014958.1  homeobox protein Meis2 isoform X8

      UniProtKB/TrEMBL
      Q3TY73
      Conserved Domains (2) summary
      pfam05920
      Location:357396
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:110194
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    14. XM_006498864.5XP_006498927.1  homeobox protein Meis2 isoform X3

      Conserved Domains (2) summary
      pfam05920
      Location:357396
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:110194
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    15. XM_030248225.2XP_030104085.1  homeobox protein Meis2 isoform X11

      Conserved Domains (2) summary
      pfam05920
      Location:148187
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:148
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    16. XM_030248226.2XP_030104086.1  homeobox protein Meis2 isoform X12

      Conserved Domains (2) summary
      pfam05920
      Location:148187
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:148
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1