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    Adora2a adenosine A2a receptor [ Mus musculus (house mouse) ]

    Gene ID: 11540, updated on 3-Dec-2024

    Summary

    Official Symbol
    Adora2aprovided by MGI
    Official Full Name
    adenosine A2a receptorprovided by MGI
    Primary source
    MGI:MGI:99402
    See related
    Ensembl:ENSMUSG00000020178 AllianceGenome:MGI:99402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A2aR; A2AAR; AA2AR; ARA2A
    Summary
    Enables G protein-coupled adenosine receptor activity. Involved in G protein-coupled adenosine receptor signaling pathway. Acts upstream of or within several processes, including chemical synaptic transmission; positive regulation of cell communication; and response to amphetamine. Located in plasma membrane. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; intestine; and liver and biliary system. Used to study myopia and primary pulmonary hypertension. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA2A (adenosine A2a receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thymus adult (RPKM 8.8), spleen adult (RPKM 8.0) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Adora2a in Genome Data Viewer
    Location:
    10 C1; 10 38.52 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75152711..75170626)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75316877..75334792)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene BCR activator of RhoGEF and GTPase Neighboring gene STARR-positive B cell enhancer ABC_E10622 Neighboring gene STARR-positive B cell enhancer mm9_chr10:74614065-74614365 Neighboring gene STARR-seq mESC enhancer starr_27150 Neighboring gene STARR-positive B cell enhancer ABC_E2943 Neighboring gene sperm antigen with calponin homology and coiled-coil domains 1-like Neighboring gene STARR-seq mESC enhancer starr_27151 Neighboring gene predicted gene, 46234 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:74783131-74783284 Neighboring gene STARR-positive B cell enhancer mm9_chr10:74789485-74789786 Neighboring gene STARR-seq mESC enhancer starr_27152 Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene STARR-seq mESC enhancer starr_27153 Neighboring gene predicted gene, 40694

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC118414

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled adenosine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled adenosine receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled adenosine receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables G protein-coupled adenosine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables alpha-actinin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables alpha-actinin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables type 5 metabotropic glutamate receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables type 5 metabotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled adenosine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within G protein-coupled adenosine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in G protein-coupled adenosine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within G protein-coupled adenosine receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within G protein-coupled adenosine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in G protein-coupled adenosine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in astrocyte activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in astrocyte activation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within eating behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in eating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inhibition of non-skeletal tissue mineralization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within inhibitory postsynaptic potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane depolarization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of alpha-beta T cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular permeability IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of vascular permeability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of acetylcholine secretion, neurotransmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of acetylcholine secretion, neurotransmission ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of circadian sleep/wake cycle, sleep IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of circadian sleep/wake cycle, sleep ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glutamate secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of glutamate secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of synaptic transmission, GABAergic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of synaptic transmission, GABAergic IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of urine volume IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of urine volume ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prepulse inhibition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in prepulse inhibition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in presynaptic modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in presynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitochondrial membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of norepinephrine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of norepinephrine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to alkaloid ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to amphetamine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to caffeine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to caffeine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic transmission, cholinergic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic transmission, cholinergic ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within synaptic transmission, dopaminergic IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vasodilation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vasodilation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in asymmetric synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in asymmetric synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axolemma IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axolemma ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intermediate filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic active zone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331095.2NP_001318024.1  adenosine receptor A2a isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AC137067
      Consensus CDS
      CCDS23924.1
      UniProtKB/Swiss-Prot
      Q2NLC1, Q60613
      Conserved Domains (1) summary
      cd15068
      Location:4294
      7tmA_Adenosine_R_A2A; adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001331096.2NP_001318025.1  adenosine receptor A2a isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AC137067
      Consensus CDS
      CCDS23924.1
      UniProtKB/Swiss-Prot
      Q2NLC1, Q60613
      Conserved Domains (1) summary
      cd15068
      Location:4294
      7tmA_Adenosine_R_A2A; adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_001428349.1NP_001415278.1  adenosine receptor A2a isoform a

      Status: VALIDATED

      Source sequence(s)
      AC137067
      UniProtKB/Swiss-Prot
      Q2NLC1, Q60613
    4. NM_001428350.1NP_001415279.1  adenosine receptor A2a isoform b

      Status: VALIDATED

      Source sequence(s)
      AC137067
      UniProtKB/TrEMBL
      Q8CAU3
    5. NM_001428351.1NP_001415280.1  adenosine receptor A2a isoform b

      Status: VALIDATED

      Source sequence(s)
      AC137067
      UniProtKB/TrEMBL
      Q8CAU3
    6. NM_001428352.1NP_001415281.1  adenosine receptor A2a isoform b

      Status: VALIDATED

      Source sequence(s)
      AC137067
      UniProtKB/TrEMBL
      Q8CAU3
    7. NM_001428353.1NP_001415282.1  adenosine receptor A2a isoform b

      Status: VALIDATED

      Source sequence(s)
      AC137067
      UniProtKB/TrEMBL
      Q8CAU3
    8. NM_009630.4NP_033760.2  adenosine receptor A2a isoform a

      See identical proteins and their annotated locations for NP_033760.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1), as well as variants 2-4, encodes the longer isoform (a).
      Source sequence(s)
      AC137067
      Consensus CDS
      CCDS23924.1
      UniProtKB/Swiss-Prot
      Q2NLC1, Q60613
      Related
      ENSMUSP00000101060.2, ENSMUST00000105420.3
      Conserved Domains (1) summary
      cd15068
      Location:4294
      7tmA_Adenosine_R_A2A; adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      75152711..75170626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244829.2XP_030100689.1  adenosine receptor A2a isoform X2

      Conserved Domains (2) summary
      cd14964
      Location:321
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:2179
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. XM_006513093.5XP_006513156.1  adenosine receptor A2a isoform X1

      Conserved Domains (1) summary
      cd15068
      Location:4294
      7tmA_Adenosine_R_A2A; adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. XM_036155515.1XP_036011408.1  adenosine receptor A2a isoform X2

      Conserved Domains (2) summary
      cd14964
      Location:321
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:2179
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily