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    Dnah2 dynein, axonemal, heavy chain 2 [ Mus musculus (house mouse) ]

    Gene ID: 327954, updated on 3-Dec-2024

    Summary

    Official Symbol
    Dnah2provided by MGI
    Official Full Name
    dynein, axonemal, heavy chain 2provided by MGI
    Primary source
    MGI:MGI:107731
    See related
    Ensembl:ENSMUSG00000005237 AllianceGenome:MGI:107731
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dnhd3; Dnahc2; 4930564A01; D130094J20; 2900022L05Rik; D330014H01Rik
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in cilium movement. Located in motile cilium. Part of axonemal dynein complex. Is expressed in central nervous system. Human ortholog(s) of this gene implicated in spermatogenic failure 45. Orthologous to human DNAH2 (dynein axonemal heavy chain 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 9.8), ovary adult (RPKM 1.9) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dnah2 in Genome Data Viewer
    Location:
    11 B3; 11 42.63 cM
    Exon count:
    95
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69311635..69439934, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69420807..69549108, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5241 Neighboring gene STARR-positive B cell enhancer ABC_E2996 Neighboring gene STARR-positive B cell enhancer ABC_E5242 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69223376-69223485 Neighboring gene transmembrane protein 88 Neighboring gene N(alpha)-acetyltransferase 38, NatC auxiliary subunit Neighboring gene KDM1 lysine (K)-specific demethylase 6B Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69231989-69232098 Neighboring gene predicted gene, 51903 Neighboring gene STARR-seq mESC enhancer starr_29847 Neighboring gene STARR-seq mESC enhancer starr_29849 Neighboring gene ephrin B3 Neighboring gene WD repeat containing, antisense to Trp53 Neighboring gene ribosomal protein S27, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dynein light intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables minus-end-directed microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cilium movement IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cilium-dependent cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cilium-dependent cell motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in inner dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inner dynein arm assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of axonemal dynein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of inner dynein arm ISM
    Inferred from Sequence Model
    more info
    PubMed 
    part_of inner dynein arm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in motile cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    dynein axonemal heavy chain 2
    Names
    axonemal beta dynein heavy chain 2
    axonemal dynein heavy chain
    ciliary dynein heavy chain 2
    dynein heavy chain 2, axonemal
    dynein heavy chain domain 3
    dynein, axon, heavy chain 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081330.1NP_001074799.1  dynein axonemal heavy chain 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL596125, AL731687
      Consensus CDS
      CCDS36192.1
      UniProtKB/Swiss-Prot
      B1AR18, O08826, P0C6F1, Q8C0U5
      UniProtKB/TrEMBL
      D3Z667, Q5F222
      Related
      ENSMUSP00000104299.2, ENSMUST00000108659.2
      Conserved Domains (6) summary
      pfam03028
      Location:37594450
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08385
      Location:275760
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:12581663
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:30413373
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:34013617
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:18002030
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_001419927.1NP_001406856.1  dynein axonemal heavy chain 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596125, AL731687
      UniProtKB/Swiss-Prot
      B1AR18, O08826, P0C6F1, Q8C0U5
      UniProtKB/TrEMBL
      Q5F222

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69311635..69439934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156769.1XP_036012662.1  dynein axonemal heavy chain 2 isoform X3

      UniProtKB/Swiss-Prot
      B1AR18, O08826, P0C6F1, Q8C0U5
      UniProtKB/TrEMBL
      Q5F222
      Conserved Domains (6) summary
      COG5245
      Location:13734040
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:241798
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam12774
      Location:18462172
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:28133073
      AAA_8; P-loop containing dynein motor region D4
      pfam18198
      Location:40324134
      AAA_lid_11; Dynein heavy chain AAA lid domain
      pfam18199
      Location:41404440
      Dynein_C; Dynein heavy chain C-terminal domain
    2. XM_030246089.2XP_030101949.1  dynein axonemal heavy chain 2 isoform X2

      UniProtKB/Swiss-Prot
      B1AR18, O08826, P0C6F1, Q8C0U5
      UniProtKB/TrEMBL
      Q5F222
      Conserved Domains (5) summary
      COG5245
      Location:13124128
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:180737
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:12401648
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:17852111
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:41434443
      Dynein_C; Dynein heavy chain C-terminal domain
    3. XM_036156771.1XP_036012664.1  dynein axonemal heavy chain 2 isoform X5

      UniProtKB/Swiss-Prot
      B1AR18, O08826, P0C6F1, Q8C0U5
      UniProtKB/TrEMBL
      Q5F222
      Conserved Domains (5) summary
      COG5245
      Location:13734090
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:241798
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam12774
      Location:18462172
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:27142974
      AAA_8; P-loop containing dynein motor region D4
      pfam18199
      Location:41054405
      Dynein_C; Dynein heavy chain C-terminal domain
    4. XM_036156770.1XP_036012663.1  dynein axonemal heavy chain 2 isoform X4

      UniProtKB/Swiss-Prot
      B1AR18, O08826, P0C6F1, Q8C0U5
      UniProtKB/TrEMBL
      Q5F222
      Conserved Domains (4) summary
      COG5245
      Location:13014117
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:169726
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam12774
      Location:17742100
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:41324432
      Dynein_C; Dynein heavy chain C-terminal domain
    5. XM_006533559.3XP_006533622.1  dynein axonemal heavy chain 2 isoform X7

      See identical proteins and their annotated locations for XP_006533622.1

      UniProtKB/Swiss-Prot
      B1AR18, O08826, P0C6F1, Q8C0U5
      UniProtKB/TrEMBL
      Q5F222
      Conserved Domains (5) summary
      COG5245
      Location:6343450
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:159
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:562970
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:11071433
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:34653765
      Dynein_C; Dynein heavy chain C-terminal domain
    6. XM_006533560.5XP_006533623.1  dynein axonemal heavy chain 2 isoform X7

      See identical proteins and their annotated locations for XP_006533623.1

      UniProtKB/Swiss-Prot
      B1AR18, O08826, P0C6F1, Q8C0U5
      UniProtKB/TrEMBL
      Q5F222
      Conserved Domains (5) summary
      COG5245
      Location:6343450
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:159
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:562970
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:11071433
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:34653765
      Dynein_C; Dynein heavy chain C-terminal domain
    7. XM_017314611.3XP_017170100.1  dynein axonemal heavy chain 2 isoform X7

      UniProtKB/Swiss-Prot
      B1AR18, O08826, P0C6F1, Q8C0U5
      UniProtKB/TrEMBL
      Q5F222
      Conserved Domains (5) summary
      COG5245
      Location:6343450
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:159
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:562970
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:11071433
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:34653765
      Dynein_C; Dynein heavy chain C-terminal domain
    8. XM_030246092.1XP_030101952.1  dynein axonemal heavy chain 2 isoform X9

      Conserved Domains (4) summary
      COG5245
      Location:322432
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12774
      Location:89415
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:10561316
      AAA_8; P-loop containing dynein motor region D4
      pfam18199
      Location:24472747
      Dynein_C; Dynein heavy chain C-terminal domain
    9. XM_036156772.1XP_036012665.1  dynein axonemal heavy chain 2 isoform X6

      UniProtKB/Swiss-Prot
      B1AR18, O08826, P0C6F1, Q8C0U5
      UniProtKB/TrEMBL
      Q5F222
      Conserved Domains (4) summary
      COG5245
      Location:13734023
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:241798
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam12774
      Location:18462172
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:28133073
      AAA_8; P-loop containing dynein motor region D4
    10. XM_036156773.1XP_036012666.1  dynein axonemal heavy chain 2 isoform X8

      Conserved Domains (8) summary
      pfam12777
      Location:30873229
      MT; Microtubule-binding stalk of dynein motor
      pfam17857
      Location:26692759
      AAA_lid_1; AAA+ lid domain
      pfam08385
      Location:241798
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:13011709
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:18462172
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12775
      Location:24582638
      AAA_7; P-loop containing dynein motor region D3
      pfam12780
      Location:28133073
      AAA_8; P-loop containing dynein motor region D4
      pfam17852
      Location:23342452
      Dynein_AAA_lid; Dynein heavy chain AAA lid domain

    RNA

    1. XR_004936978.1 RNA Sequence

    2. XR_004936979.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177617.2: Suppressed sequence

      Description
      NM_177617.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.