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    C8g complement component 8, gamma polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 69379, updated on 9-Dec-2024

    Summary

    Official Symbol
    C8gprovided by MGI
    Official Full Name
    complement component 8, gamma polypeptideprovided by MGI
    Primary source
    MGI:MGI:88237
    See related
    Ensembl:ENSMUSG00000015083 AllianceGenome:MGI:88237
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a secreted protein that is a core component of the complement 8 (C8) complex. C8 is part of the membrane attack complex which participates in the innate immune response against bacterial pathogens. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
    Expression
    Biased expression in liver adult (RPKM 279.9), liver E18 (RPKM 36.0) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See C8g in Genome Data Viewer
    Location:
    2 A3; 2 17.31 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25388662..25391731, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25498650..25501777, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 35287 Neighboring gene lipocalin 12 Neighboring gene STARR-positive B cell enhancer ABC_E9193 Neighboring gene F-box and WD-40 domain protein 5 Neighboring gene TNF receptor-associated factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E273 Neighboring gene cytochrome c oxidase subunit 7A2, mitochondrial pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:25404685-25404887 Neighboring gene STARR-positive B cell enhancer ABC_E11127 Neighboring gene predicted gene, 35476

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables complement binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables retinol binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in complement activation, alternative pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in killing of cells of another organism IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of membrane attack complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    complement component C8 gamma chain
    Names
    complement component 8, gamma subunit
    novel lipocalin protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271777.1NP_001258706.1  complement component C8 gamma chain isoform 2

      See identical proteins and their annotated locations for NP_001258706.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK005962, AL732557
      Consensus CDS
      CCDS71001.1
      UniProtKB/TrEMBL
      Q9DAC2
      Related
      ENSMUSP00000015227.4, ENSMUST00000015227.4
      Conserved Domains (1) summary
      pfam00061
      Location:14150
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    2. NM_001421917.1NP_001408846.1  complement component C8 gamma chain isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AL732557
    3. NM_001421918.1NP_001408847.1  complement component C8 gamma chain isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL732557
    4. NM_001421919.1NP_001408848.1  complement component C8 gamma chain isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL732557
    5. NM_027062.3NP_081338.1  complement component C8 gamma chain isoform 1 precursor

      See identical proteins and their annotated locations for NP_081338.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AL732557
      Consensus CDS
      CCDS15777.1
      UniProtKB/Swiss-Prot
      Q8VCG4
      Related
      ENSMUSP00000041855.5, ENSMUST00000040042.11
      Conserved Domains (1) summary
      pfam00061
      Location:48184
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25388662..25391731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)