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    Fbxw2 F-box and WD-40 domain protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 30050, updated on 3-Dec-2024

    Summary

    Official Symbol
    Fbxw2provided by MGI
    Official Full Name
    F-box and WD-40 domain protein 2provided by MGI
    Primary source
    MGI:MGI:1353435
    See related
    Ensembl:ENSMUSG00000035949 AllianceGenome:MGI:1353435
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MD6; FBW2; Fwd2; 2700071L08Rik
    Summary
    Located in cytoplasm. Is expressed in central nervous system; retina; and urinary system. Orthologous to human FBXW2 (F-box and WD repeat domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 8.5), bladder adult (RPKM 8.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Fbxw2 in Genome Data Viewer
    Location:
    2; 2 B
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34694185..34716229, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (34804364..34826282, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Rab9 effector protein with kelch motifs Neighboring gene heat shock protein 5 Neighboring gene predicted gene, 53241 Neighboring gene STARR-seq mESC enhancer starr_04266 Neighboring gene STARR-seq mESC enhancer starr_04267 Neighboring gene beta-1,3-galactosyltransferase 9 Neighboring gene STARR-seq mESC enhancer starr_04268 Neighboring gene STARR-seq mESC enhancer starr_04269 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 Neighboring gene STARR-positive B cell enhancer ABC_E3369

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    F-box/WD repeat-containing protein 2
    Names
    F-box and WD-40 domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164769.2NP_001158241.1  F-box/WD repeat-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001158241.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks the 3' exon, but has an alternate 3' sequence, compared to variant 1. The resulting isoform (2) is C-terminal truncated, compared to isoform 1.
      Source sequence(s)
      AL929106
      Consensus CDS
      CCDS50574.1
      UniProtKB/Swiss-Prot
      E9PXP3, Q60584
      UniProtKB/TrEMBL
      Q8BS25
      Related
      ENSMUSP00000108698.2, ENSMUST00000113075.8
      Conserved Domains (4) summary
      smart00256
      Location:6094
      FBOX; A Receptor for Ubiquitination Targets
      COG2319
      Location:140359
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:151185
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:140354
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001164770.2NP_001158242.1  F-box/WD repeat-containing protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001158242.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an internal segment in the 5' region, resulting in a downstream in-frame AUG start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL929106
      Consensus CDS
      CCDS50573.1
      UniProtKB/TrEMBL
      A2AUF9
      Related
      ENSMUSP00000088541.4, ENSMUST00000091020.10
      Conserved Domains (2) summary
      sd00039
      Location:2256
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:11318
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. NM_001164772.2NP_001158244.1  F-box/WD repeat-containing protein 2 isoform 4

      See identical proteins and their annotated locations for NP_001158244.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks several 3' exons, but has an alternate 3' sequence, compared to variant 1. The resulting isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL929106
      UniProtKB/TrEMBL
      Q99L53, Q9CPQ6
      Conserved Domains (4) summary
      smart00256
      Location:6094
      FBOX; A Receptor for Ubiquitination Targets
      COG2319
      Location:142236
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:151185
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:140232
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. NM_001379115.2NP_001366044.1  F-box/WD repeat-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL929106
      UniProtKB/TrEMBL
      A2AUF9
      Conserved Domains (2) summary
      sd00039
      Location:2256
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:11318
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. NM_001379116.2NP_001366045.1  F-box/WD repeat-containing protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL929106
      Conserved Domains (2) summary
      sd00039
      Location:2256
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:11286
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    6. NM_001379117.2NP_001366046.1  F-box/WD repeat-containing protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL929106
      UniProtKB/TrEMBL
      Q8CCH8
      Conserved Domains (3) summary
      smart00256
      Location:6094
      FBOX; A Receptor for Ubiquitination Targets
      sd00039
      Location:151185
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:140415
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    7. NM_001379118.2NP_001366047.1  F-box/WD repeat-containing protein 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL929106
      Conserved Domains (3) summary
      smart00256
      Location:6094
      FBOX; A Receptor for Ubiquitination Targets
      sd00039
      Location:151185
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:140280
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    8. NM_001406267.1NP_001393196.1  F-box/WD repeat-containing protein 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL929106
      UniProtKB/TrEMBL
      Q8CCH8
    9. NM_001406268.1NP_001393197.1  F-box/WD repeat-containing protein 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL929106
      UniProtKB/TrEMBL
      Q8CCH8
    10. NM_001406269.1NP_001393198.1  F-box/WD repeat-containing protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL929106
      UniProtKB/TrEMBL
      Q8CCH8, Q9QUH1
      Related
      ENSMUSP00000028220.4, ENSMUST00000028220.10
    11. NM_001406270.1NP_001393199.1  F-box/WD repeat-containing protein 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL929106
      UniProtKB/TrEMBL
      A2AUG1
      Related
      ENSMUSP00000108700.2, ENSMUST00000113077.8
    12. NM_001406271.1NP_001393200.1  F-box/WD repeat-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL929106
      UniProtKB/TrEMBL
      A2AUF9
    13. NM_001406272.1NP_001393201.1  F-box/WD repeat-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL929106
      UniProtKB/TrEMBL
      A2AUF9
    14. NM_001406273.1NP_001393202.1  F-box/WD repeat-containing protein 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL929106
    15. NM_001406274.1NP_001393203.1  F-box/WD repeat-containing protein 2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL929106
      UniProtKB/TrEMBL
      Q99L53
    16. NM_001406275.1NP_001393204.1  F-box/WD repeat-containing protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL929106
      UniProtKB/TrEMBL
      Q99L53, Q9CPQ6
    17. NM_001406276.1NP_001393205.1  F-box/WD repeat-containing protein 2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL929106
      UniProtKB/TrEMBL
      Q9D5X2
      Related
      ENSMUST00000134323.2
    18. NM_001406277.1NP_001393206.1  F-box/WD repeat-containing protein 2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL929106
      Related
      ENSMUST00000156130.2
    19. NM_001406278.1NP_001393207.1  F-box/WD repeat-containing protein 2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL929106
    20. NM_001406279.1NP_001393208.1  F-box/WD repeat-containing protein 2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL929106
    21. NM_013890.5NP_038918.3  F-box/WD repeat-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_038918.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AL929106
      Consensus CDS
      CCDS15952.1
      UniProtKB/TrEMBL
      Q8CCH8, Q9QUH1
      Related
      ENSMUSP00000108703.3, ENSMUST00000113080.9
      Conserved Domains (3) summary
      smart00256
      Location:6094
      FBOX; A Receptor for Ubiquitination Targets
      sd00039
      Location:151185
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:140447
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      34694185..34716229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001164768.1: Suppressed sequence

      Description
      NM_001164768.1: This RefSeq was removed because currently there is insufficient support for the transcript.