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    Cd19 CD19 antigen [ Mus musculus (house mouse) ]

    Gene ID: 12478, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cd19provided by MGI
    Official Full Name
    CD19 antigenprovided by MGI
    Primary source
    MGI:MGI:88319
    See related
    Ensembl:ENSMUSG00000030724 AllianceGenome:MGI:88319
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Involved in several processes, including B-1 B cell differentiation; positive regulation of release of sequestered calcium ion into cytosol; and regulation of signal transduction. Acts upstream of or within B cell receptor signaling pathway. Located in external side of plasma membrane. Is expressed in liver and spleen. Human ortholog(s) of this gene implicated in common variable immunodeficiency 3. Orthologous to human CD19 (CD19 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 117.1), mammary gland adult (RPKM 26.5) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Cd19 in Genome Data Viewer
    Location:
    7 F3; 7 69.01 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126007620..126016401, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126408448..126415148, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133521004-133521187 Neighboring gene SPNS lysolipid transporter 1, lysophospholipid Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein Neighboring gene STARR-seq mESC enhancer starr_20144 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133540343-133540526 Neighboring gene STARR-positive B cell enhancer ABC_E8208 Neighboring gene STARR-positive B cell enhancer ABC_E9706 Neighboring gene STARR-positive B cell enhancer ABC_E9707 Neighboring gene rabaptin, RAB GTPase binding effector protein 2 Neighboring gene ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133618829-133619012 Neighboring gene SH2B adaptor protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in B cell mediated immunity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in B cell proliferation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in B cell proliferation involved in immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within B cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in B cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in B-1 B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in antigen receptor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antigen receptor-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in immunoglobulin mediated immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in immunoglobulin mediated immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of release of sequestered calcium ion into cytosol IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of release of sequestered calcium ion into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of release of sequestered calcium ion into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of B cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of B cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of B cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of B cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    B-lymphocyte antigen CD19
    Names
    differentiation antigen CD19

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357091.2NP_001344020.1  B-lymphocyte antigen CD19 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC125322
      Consensus CDS
      CCDS90327.1
      UniProtKB/TrEMBL
      A0A0X1KG58, Q3U1A5
      Related
      ENSMUSP00000032968.7, ENSMUST00000032968.7
      Conserved Domains (2) summary
      smart00410
      Location:183263
      IG_like; Immunoglobulin like
      cd04979
      Location:21118
      Ig_Semaphorin_C; Immunoglobulin (Ig)-like domain of semaphorin
    2. NM_009844.3NP_033974.2  B-lymphocyte antigen CD19 isoform 1 precursor

      See identical proteins and their annotated locations for NP_033974.2

      Status: VALIDATED

      Source sequence(s)
      AC125322
      Consensus CDS
      CCDS21828.1
      UniProtKB/Swiss-Prot
      P25918, Q542B2
      UniProtKB/TrEMBL
      Q3TA95
      Related
      ENSMUSP00000145803.2, ENSMUST00000206325.2
      Conserved Domains (3) summary
      cd04979
      Location:21118
      Ig_Semaphorin_C; Immunoglobulin (Ig)-like domain of semaphorin
      smart00410
      Location:26115
      IG_like; Immunoglobulin like
      cl11960
      Location:180259
      Ig; Immunoglobulin domain

    RNA

    1. NR_178083.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125322

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126007620..126016401 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152614.1XP_036008507.1  B-lymphocyte antigen CD19 isoform X1

      UniProtKB/TrEMBL
      Q3TQG5
      Conserved Domains (2) summary
      cd00096
      Location:7078
      Ig; Ig strand B [structural motif]
      cl11960
      Location:65147
      Ig; Immunoglobulin domain
    2. XM_036152615.1XP_036008508.1  B-lymphocyte antigen CD19 isoform X2

      Related
      ENSMUST00000205997.2