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    Zc3h7b zinc finger CCCH type containing 7B [ Mus musculus (house mouse) ]

    Gene ID: 20286, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zc3h7bprovided by MGI
    Official Full Name
    zinc finger CCCH type containing 7Bprovided by MGI
    Primary source
    MGI:MGI:1328310
    See related
    Ensembl:ENSMUSG00000022390 AllianceGenome:MGI:1328310
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm627; Scrg3; Zc2h7b; mKIAA1031
    Summary
    Predicted to enable miRNA binding activity. Predicted to be involved in miRNA processing. Predicted to act upstream of with a positive effect on post-transcriptional regulation of gene expression. Orthologous to human ZC3H7B (zinc finger CCCH-type containing 7B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 16.5), whole brain E14.5 (RPKM 16.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zc3h7b in Genome Data Viewer
    Location:
    15 E1; 15 38.23 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81629299..81680470)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81745098..81796269)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene L3MBTL2 polycomb repressive complex 1 subunit Neighboring gene STARR-seq mESC enhancer starr_39263 Neighboring gene chondroadherin-like Neighboring gene RAN GTPase activating protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1915 Neighboring gene STARR-seq mESC enhancer starr_39269 Neighboring gene STARR-positive B cell enhancer ABC_E944 Neighboring gene predicted gene, 17597 Neighboring gene thyrotroph embryonic factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. Dandoy-Dron F, et al. J Biol Chem, 1998 Mar 27. PMID 9516475
    2. Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells. Abramova N, et al. Dev Biol, 2005 Jul 15. PMID 15890332
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    4. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables miRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect post-transcriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCCH domain-containing protein 7B
    Names
    scrapie responsive gene 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081016.2 → NP_001074485.1  zinc finger CCCH domain-containing protein 7B

      See identical proteins and their annotated locations for NP_001074485.1

      Status: VALIDATED

      Source sequence(s)
      AC158970
      Consensus CDS
      CCDS37150.1
      UniProtKB/TrEMBL
      F8VPP8
      Related
      ENSMUSP00000105181.2, ENSMUST00000109554.3
      Conserved Domains (5) summary
      TIGR00990
      Location:18 → 162
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00020
      Location:845 → 867
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00006
      Location:39 → 64
      TPR; TPR repeat [structural motif]
      pfam00642
      Location:891 → 913
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam12171
      Location:845 → 868
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      81629299..81680470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316520.2 → XP_017172009.1  zinc finger CCCH domain-containing protein 7B isoform X2

      UniProtKB/TrEMBL
      F8VPP8
      Conserved Domains (5) summary
      TIGR00990
      Location:18 → 162
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00020
      Location:845 → 867
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00006
      Location:39 → 64
      TPR; TPR repeat [structural motif]
      pfam00642
      Location:891 → 913
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam12171
      Location:845 → 868
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    Nucleotide Protein Strain
    Heading Accession and Version

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