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    Cyb5d2 cytochrome b5 domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 192986, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cyb5d2provided by MGI
    Official Full Name
    cytochrome b5 domain containing 2provided by MGI
    Primary source
    MGI:MGI:2684848
    See related
    Ensembl:ENSMUSG00000057778 AllianceGenome:MGI:2684848
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm2; 9330151E16Rik
    Summary
    Enables heme binding activity. Acts upstream of or within positive regulation of neuron differentiation. Located in extracellular region. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and immune system. Orthologous to human CYB5D2 (cytochrome b5 domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 4.1), testis adult (RPKM 3.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Cyb5d2 in Genome Data Viewer
    Location:
    11 B4; 11 44.51 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72668058..72686665, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72777232..72795839, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2G 1 Neighboring gene predicted gene, 24143 Neighboring gene STARR-seq mESC enhancer starr_29916 Neighboring gene STARR-positive B cell enhancer ABC_E7012 Neighboring gene ankyrin repeat and FYVE domain containing 1 Neighboring gene predicted gene, 46287 Neighboring gene STARR-positive B cell enhancer ABC_E8424 Neighboring gene zinc finger, ZZ-type with EF hand domain 1 Neighboring gene signal recognition particle receptor ('docking protein') pseudogene Neighboring gene predicted gene, 26121

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    neuferricin
    Names
    cytochrome b5 domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024926.3NP_001020097.2  neuferricin precursor

      See identical proteins and their annotated locations for NP_001020097.2

      Status: VALIDATED

      Source sequence(s)
      AK034043, BC086682, BX632403, CD776759, CJ150252, CJ151047, CJ284318
      Consensus CDS
      CCDS24990.2
      UniProtKB/Swiss-Prot
      A0AUN6, Q0VGS6, Q5SSH8, Q8BHV3
      Related
      ENSMUSP00000078623.6, ENSMUST00000079681.6
      Conserved Domains (1) summary
      pfam00173
      Location:3791
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      72668058..72686665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)