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    Psma3 proteasome subunit alpha 3 [ Mus musculus (house mouse) ]

    Gene ID: 19167, updated on 3-Dec-2024

    Summary

    Official Symbol
    Psma3provided by MGI
    Official Full Name
    proteasome subunit alpha 3provided by MGI
    Primary source
    MGI:MGI:104883
    See related
    Ensembl:ENSMUSG00000060073 AllianceGenome:MGI:104883
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lmpc8
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of endopeptidase activity. Part of proteasome core complex. Is expressed in several structures, including central nervous system; cranium; dorsal root ganglion; lung; and tooth. Orthologous to human PSMA3 (proteasome 20S subunit alpha 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 35.7), CNS E11.5 (RPKM 28.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Psma3 in Genome Data Viewer
    Location:
    12 C2; 12 29.39 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (71016082..71042651)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (70969283..70995877)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8488 Neighboring gene ARP10 actin-related protein 10 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:72069569-72069678 Neighboring gene STARR-positive B cell enhancer ABC_E1441 Neighboring gene STARR-positive B cell enhancer ABC_E7144 Neighboring gene STARR-positive B cell enhancer ABC_E1442 Neighboring gene nuclear encoded tRNA lysine 17 (anticodon CTT) Neighboring gene RIKEN cDNA 3110056K07 gene Neighboring gene STARR-positive B cell enhancer ABC_E11778 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:72116322-72116431 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:72116588-72116697 Neighboring gene AT-rich interaction domain 4A Neighboring gene STARR-seq mESC enhancer starr_32414 Neighboring gene STARR-positive B cell enhancer ABC_E7145 Neighboring gene STARR-seq mESC enhancer starr_32415 Neighboring gene translocase of outer mitochondrial membrane 20-like Neighboring gene predicted gene, 32906

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome core complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome core complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome core complex, alpha-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of proteasome core complex, alpha-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    proteasome subunit alpha type-3
    Names
    alpha-7
    macropain subunit C8
    multicatalytic endopeptidase complex subunit C8
    proteasome (prosome, macropain) subunit, alpha type 3
    proteasome component C8
    proteasome subunit K
    proteasome subunit alpha-7
    NP_001297524.1
    NP_001297525.1
    NP_001409967.1
    NP_001409969.1
    NP_001409970.1
    NP_001409971.1
    NP_001409974.1
    NP_035314.3
    XP_036013150.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310595.1NP_001297524.1  proteasome subunit alpha type-3 isoform b

      See identical proteins and their annotated locations for NP_001297524.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start site, compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC132325, AI303320, AK169577, BY159585
      Consensus CDS
      CCDS79119.1
      UniProtKB/TrEMBL
      E0CX62, Q3TEL1
      Related
      ENSMUSP00000124894.3, ENSMUST00000160864.8
      Conserved Domains (1) summary
      cl00467
      Location:1142
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
    2. NM_001310596.1NP_001297525.1  proteasome subunit alpha type-3 isoform b

      See identical proteins and their annotated locations for NP_001297525.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start site, compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC132325
      Consensus CDS
      CCDS79119.1
      UniProtKB/TrEMBL
      E0CX62, Q3TEL1
      Conserved Domains (1) summary
      cl00467
      Location:1142
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
    3. NM_001423038.1NP_001409967.1  proteasome subunit alpha type-3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC132325
      UniProtKB/Swiss-Prot
      O70435
      UniProtKB/TrEMBL
      Q58EV4, Q9DCD8
    4. NM_001423040.1NP_001409969.1  proteasome subunit alpha type-3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC132325
      UniProtKB/TrEMBL
      E0CX62, Q3TEL1
    5. NM_001423041.1NP_001409970.1  proteasome subunit alpha type-3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC132325
      UniProtKB/TrEMBL
      Q3TEL1
    6. NM_001423042.1NP_001409971.1  proteasome subunit alpha type-3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC132325
      UniProtKB/TrEMBL
      Q3TEL1
    7. NM_001423045.1NP_001409974.1  proteasome subunit alpha type-3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC132325
      UniProtKB/Swiss-Prot
      O70435
      UniProtKB/TrEMBL
      Q58EV4, Q9DCD8
    8. NM_011184.5NP_035314.3  proteasome subunit alpha type-3 isoform a

      See identical proteins and their annotated locations for NP_035314.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC132325, AI303320, AK168495, BY159585
      Consensus CDS
      CCDS25961.1
      UniProtKB/Swiss-Prot
      O70435
      UniProtKB/TrEMBL
      Q58EV4, Q9DCD8
      Related
      ENSMUSP00000125548.2, ENSMUST00000160027.8
      Conserved Domains (1) summary
      cd03751
      Location:5217
      proteasome_alpha_type_3; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      71016082..71042651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157257.1XP_036013150.1  proteasome subunit alpha type-3 isoform X2

      UniProtKB/TrEMBL
      Q9DCD8
      Conserved Domains (1) summary
      cd03751
      Location:5195
      proteasome_alpha_type_3; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...