U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Palld palladin, cytoskeletal associated protein [ Mus musculus (house mouse) ]

    Gene ID: 72333, updated on 27-Nov-2024

    Summary

    Official Symbol
    Palldprovided by MGI
    Official Full Name
    palladin, cytoskeletal associated proteinprovided by MGI
    Primary source
    MGI:MGI:1919583
    See related
    Ensembl:ENSMUSG00000058056 AllianceGenome:MGI:1919583
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6030492A02; 2410003B16Rik
    Summary
    Predicted to enable axon guidance receptor activity and cytoskeletal protein binding activity. Acts upstream of or within actin cytoskeleton organization; epithelial cell morphogenesis; and keratinocyte development. Located in Z disc; focal adhesion; and stress fiber. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; heart; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human PALLD (palladin, cytoskeletal associated protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 40.1), ovary adult (RPKM 20.2) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Palld in Genome Data Viewer
    Location:
    8 B3.1; 8 31.23 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (61964465..62355741, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (61511431..61902707, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene SH3 domain containing ring finger 1 Neighboring gene STARR-positive B cell enhancer ABC_E10501 Neighboring gene STARR-seq mESC enhancer starr_21586 Neighboring gene STARR-seq mESC enhancer starr_21587 Neighboring gene predicted gene, 53435 Neighboring gene STARR-seq mESC enhancer starr_21588 Neighboring gene STARR-seq mESC enhancer starr_21589 Neighboring gene carbonyl reductase 4 Neighboring gene STARR-seq mESC enhancer starr_21591 Neighboring gene STARR-seq mESC enhancer starr_21593 Neighboring gene STARR-seq mESC enhancer starr_21597 Neighboring gene predicted gene, 35254 Neighboring gene STARR-seq mESC enhancer starr_21598 Neighboring gene STARR-seq mESC enhancer starr_21599 Neighboring gene predicted gene, 51576 Neighboring gene RIKEN cDNA 4930512H18 gene Neighboring gene lysyl-tRNA synthetase pseudogene Neighboring gene DExD/H box helicase 60 Neighboring gene STARR-seq mESC enhancer starr_21603 Neighboring gene STARR-seq mESC enhancer starr_21604 Neighboring gene annexin A10

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC150248

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables axon guidance receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within epithelial cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within keratinocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin filament ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in excitatory synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in podosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in podosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    palladin
    Names
    90kDa actin-associated protein palladin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081390.2NP_001074859.1  palladin isoform 4

      See identical proteins and their annotated locations for NP_001074859.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) lacks two alternate internal segments and has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC121881, AC139846, AC147616
      Consensus CDS
      CCDS40350.1
      UniProtKB/Swiss-Prot
      Q9ET54
      Related
      ENSMUSP00000034057.8, ENSMUST00000034057.14
      Conserved Domains (3) summary
      cd00096
      Location:465542
      Ig; Immunoglobulin domain
      cd05893
      Location:10341108
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:278368
      I-set; Immunoglobulin I-set domain
    2. NM_001293772.2NP_001280701.1  palladin isoform 1

      See identical proteins and their annotated locations for NP_001280701.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC121881, AC139846, AC147616
      Consensus CDS
      CCDS80882.1
      UniProtKB/Swiss-Prot
      A0JNZ3, Q69ZT7, Q6DFX7, Q9CWW1, Q9ET54
      Related
      ENSMUSP00000112442.2, ENSMUST00000121785.9
      Conserved Domains (2) summary
      cd05893
      Location:12761350
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:278368
      I-set; Immunoglobulin I-set domain
    3. NM_001293773.2NP_001280702.1  palladin isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AC121881, AC147616
      Consensus CDS
      CCDS80881.1
      UniProtKB/TrEMBL
      K0BWC3
      Related
      ENSMUSP00000113874.2, ENSMUST00000121493.9
      Conserved Domains (3) summary
      cd00096
      Location:76153
      Ig; Immunoglobulin domain
      cd05893
      Location:870944
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:754844
      I-set; Immunoglobulin I-set domain
    4. NM_001293774.2NP_001280703.1  palladin isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AC121881
      Consensus CDS
      CCDS80880.1
      UniProtKB/Swiss-Prot
      Q9ET54
      Related
      ENSMUSP00000112374.2, ENSMUST00000121200.9
      Conserved Domains (4) summary
      cd00096
      Location:415418
      Ig; Ig strand A [structural motif]
      cd05892
      Location:514605
      IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
      cd05893
      Location:281372
      IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:415505
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      61964465..62355741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242242.3XP_011240544.1  palladin isoform X1

      See identical proteins and their annotated locations for XP_011240544.1

      UniProtKB/Swiss-Prot
      A0JNZ3, Q69ZT7, Q6DFX7, Q9CWW1, Q9ET54
      Conserved Domains (2) summary
      cd05893
      Location:12761350
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:278368
      I-set; Immunoglobulin I-set domain
    2. XM_006509503.3XP_006509566.1  palladin isoform X2

      UniProtKB/Swiss-Prot
      Q9ET54
      Conserved Domains (2) summary
      cd05893
      Location:12591333
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:278368
      I-set; Immunoglobulin I-set domain
    3. XM_006509504.4XP_006509567.1  palladin isoform X4

      See identical proteins and their annotated locations for XP_006509567.1

      UniProtKB/TrEMBL
      K0BWC3
      Conserved Domains (2) summary
      cd05893
      Location:887961
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:771861
      I-set; Immunoglobulin I-set domain
    4. XM_006509505.4XP_006509568.1  palladin isoform X4

      See identical proteins and their annotated locations for XP_006509568.1

      UniProtKB/TrEMBL
      K0BWC3
      Conserved Domains (2) summary
      cd05893
      Location:887961
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:771861
      I-set; Immunoglobulin I-set domain
    5. XM_006509507.4XP_006509570.1  palladin isoform X5

      See identical proteins and their annotated locations for XP_006509570.1

      Conserved Domains (2) summary
      cd05893
      Location:548622
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:432522
      I-set; Immunoglobulin I-set domain
    6. XM_006509508.5XP_006509571.1  palladin isoform X5

      See identical proteins and their annotated locations for XP_006509571.1

      Conserved Domains (2) summary
      cd05893
      Location:548622
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:432522
      I-set; Immunoglobulin I-set domain
    7. XM_036154308.1XP_036010201.1  palladin isoform X6

      Conserved Domains (4) summary
      cd00096
      Location:415418
      Ig; Ig strand A [structural motif]
      cd05892
      Location:514605
      IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
      cd05893
      Location:281372
      IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:415505
      Ig; Immunoglobulin domain
    8. XM_036154307.1XP_036010200.1  palladin isoform X3

      Conserved Domains (6) summary
      pfam07679
      Location:448545
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:11601163
      Ig; Ig strand A [structural motif]
      cd05892
      Location:12591350
      IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
      cd05893
      Location:10261117
      IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
      cd20972
      Location:277368
      IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:11601250
      Ig; Immunoglobulin domain