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    Surf4 surfeit gene 4 [ Mus musculus (house mouse) ]

    Gene ID: 20932, updated on 3-Dec-2024

    Summary

    Official Symbol
    Surf4provided by MGI
    Official Full Name
    surfeit gene 4provided by MGI
    Primary source
    MGI:MGI:98445
    See related
    Ensembl:ENSMUSG00000014867 AllianceGenome:MGI:98445
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Surf-4
    Summary
    Enables COPII receptor activity. Involved in COPII-coated vesicle cargo loading; lipid export from cell; and lipoprotein transport. Predicted to be located in Golgi apparatus; cytosol; and nuclear membrane. Predicted to be active in COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum exit site; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in embryo and pancreas tip epithelium. Orthologous to human SURF4 (surfeit 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 218.1), large intestine adult (RPKM 165.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Surf4 in Genome Data Viewer
    Location:
    2 A3; 2 19.1 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26810052..26823801, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26920041..26933776, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 57689 Neighboring gene ribosomal protein L7A Neighboring gene surfeit gene 1 Neighboring gene surfeit gene 2 Neighboring gene STARR-positive B cell enhancer ABC_E2605 Neighboring gene serine/threonine kinase-like domain containing 1 Neighboring gene REX4, 3'-5' exonuclease Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:26819876-26820059 Neighboring gene predicted gene, 36649 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables COPII receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables COPII receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cargo receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cargo receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle cargo loading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Golgi organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid export from cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lipoprotein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipoprotein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipoprotein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of organelle organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of organelle organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of lipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of lipid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in COPII-coated ER to Golgi transport vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in COPII-coated ER to Golgi transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum exit site IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001421147.1NP_001408076.1  surfeit locus protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL773563
      UniProtKB/TrEMBL
      Q3U7E6
    2. NM_001421148.1NP_001408077.1  surfeit locus protein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL773563
      UniProtKB/TrEMBL
      Q3U7E6
    3. NM_011512.4NP_035642.1  surfeit locus protein 4 isoform 1

      See identical proteins and their annotated locations for NP_035642.1

      Status: VALIDATED

      Source sequence(s)
      AL773563
      Consensus CDS
      CCDS15817.1
      UniProtKB/Swiss-Prot
      Q64310
      UniProtKB/TrEMBL
      Q3U7E6, Q545Q2
      Related
      ENSMUSP00000015011.4, ENSMUST00000015011.10
      Conserved Domains (1) summary
      pfam02077
      Location:4269
      SURF4; SURF4 family

    RNA

    1. NR_185257.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL773563
    2. NR_185258.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL773563
    3. NR_185259.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL773563
    4. NR_185260.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL773563

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      26810052..26823801 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)