Fam107a family with sequence similarity 107, member A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fam107aprovided by MGI
Official Full Name: family with sequence similarity 107, member Aprovided by MGI
Primary source: MGI:MGI:3041256
See related: Ensembl:ENSMUSG00000021750 AllianceGenome:MGI:3041256
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DRR1
Summary: Predicted to enable actin binding activity. Involved in several processes, including actin filament organization; negative regulation of long-term synaptic potentiation; and regulation of postsynapse assembly. Located in actin cytoskeleton; neuron projection; and synapse. Is active in glutamatergic synapse; postsynaptic actin cytoskeleton; and presynaptic actin cytoskeleton. Is expressed in nervous system and sensory organ. Orthologous to human FAM107A (family with sequence similarity 107 member A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cortex adult (RPKM 93.4), cerebellum adult (RPKM 80.4) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A1; 14 4.8 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (14152166..14173503)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (8296270..8317607, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulated in renal carcinoma 1 (DRR1) mediates the differentiation of neural stem cells through transcriptional regulation.
Title: Downregulated in renal carcinoma 1 (DRR1) mediates the differentiation of neural stem cells through transcriptional regulation.
Loss of family with sequence similarity 107, member A (FAM107A) induces browning in 3T3-L1 adipocytes.
Title: Loss of family with sequence similarity 107, member A (FAM107A) induces browning in 3T3-L1 adipocytes.
Systemic inflammation further mobilized glucocorticoid signaling and in turn led to dysregulation of a large set of genes, including robust upregulation of FAM107A in the spinal cord, increased expression of which has been implicated in neurodegeneration.
Title: A severe mouse model of spinal muscular atrophy develops early systemic inflammation.
Study showed abundant expression of down-regulated in renal cell carcinoma 1 (DRR1) mRNA and protein in the adult mouse brain with pronounced differences between distinct brain regions. Glucocorticoid receptor activation induced DRR1 expression throughout the brain, with particularly strong induction in white matter and fiber tracts and in membrane-rich structures.
Title: Expression and glucocorticoid-dependent regulation of the stress-inducible protein DRR1 in the mouse adult brain.
Endogenous DRR1 localizes to some, but not all, synapses, with preference for the presynaptic region. Enhancement of DRR1 expression reduced spine density, diminished the probability of synaptic glutamate release, and altered cognitive performance.
Title: Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MTH277 (e-PCR)
- UniSTS:127254

D14Mit146.2 (e-PCR), detects polymorphism
- UniSTS:127255

AU048745 (e-PCR)
- UniSTS:145195

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament bundle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glucocorticoid stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to nutrient levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: actin-associated protein FAM107A

Names: protein FAM107A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360337.2 → NP_001347266.1 actin-associated protein FAM107A isoform 1

Status: VALIDATED

Source sequence(s)

CT025547

Consensus CDS

CCDS26813.1

UniProtKB/Swiss-Prot

Q78TU8

Related

ENSMUSP00000114015.2, ENSMUST00000121887.8

Conserved Domains (1) summary

pfam06625
Location:23 → 133

DUF1151; Protein of unknown function (DUF1151)
NM_001360338.2 → NP_001347267.1 actin-associated protein FAM107A isoform 1

Status: VALIDATED

Source sequence(s)

CT025547

Consensus CDS

CCDS26813.1

UniProtKB/Swiss-Prot

Q78TU8

Conserved Domains (1) summary

pfam06625
Location:23 → 133

DUF1151; Protein of unknown function (DUF1151)
NM_001360339.1 → NP_001347268.1 actin-associated protein FAM107A isoform 2

Status: VALIDATED

Source sequence(s)

AW047303, BY244357, CF172036, CT025547

Consensus CDS

CCDS88566.1

UniProtKB/TrEMBL

A0A5S8E879

Related

ENSMUSP00000112769.3, ENSMUST00000120411.9

Conserved Domains (1) summary

pfam06625
Location:51 → 161

DUF1151; Protein of unknown function (DUF1151)
NM_001425915.1 → NP_001412844.1 actin-associated protein FAM107A isoform 1

Status: VALIDATED

Source sequence(s)

CT025547

UniProtKB/Swiss-Prot

Q78TU8
NM_001425916.1 → NP_001412845.1 actin-associated protein FAM107A isoform 1

Status: VALIDATED

Source sequence(s)

CT025547

UniProtKB/Swiss-Prot

Q78TU8
NM_001425917.1 → NP_001412846.1 actin-associated protein FAM107A isoform 1

Status: VALIDATED

Source sequence(s)

CT025547

UniProtKB/Swiss-Prot

Q78TU8
NM_183187.5 → NP_899010.1 actin-associated protein FAM107A isoform 1

See identical proteins and their annotated locations for NP_899010.1

Status: VALIDATED

Source sequence(s)

CT025547

Consensus CDS

CCDS26813.1

UniProtKB/Swiss-Prot

Q78TU8

Related

ENSMUSP00000045513.9, ENSMUST00000036070.15

Conserved Domains (1) summary

pfam06625
Location:23 → 133

DUF1151; Protein of unknown function (DUF1151)