U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ddias DNA damage-induced apoptosis suppressor [ Mus musculus (house mouse) ]

    Gene ID: 74041, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ddiasprovided by MGI
    Official Full Name
    DNA damage-induced apoptosis suppressorprovided by MGI
    Primary source
    MGI:MGI:1921291
    See related
    Ensembl:ENSMUSG00000030641 AllianceGenome:MGI:1921291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    noxin; 4632434I11Rik
    Summary
    Acts upstream of or within several processes, including cellular response to hydroperoxide; cellular response to radiation; and negative regulation of fibroblast apoptotic process. Located in cytoplasm and nucleus. Orthologous to human DDIAS (DNA damage induced apoptosis suppressor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 4.8), liver E14 (RPKM 2.6) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ddias in Genome Data Viewer
    Location:
    7 E1; 7 51.64 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (92506734..92523455, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (92857525..92874917, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4632427E13 gene Neighboring gene STARR-seq mESC enhancer starr_19530 Neighboring gene RAB30, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E8184 Neighboring gene STARR-seq mESC enhancer starr_19531 Neighboring gene STARR-positive B cell enhancer ABC_E9697 Neighboring gene STARR-seq mESC enhancer starr_19532 Neighboring gene predicted gene, 40448 Neighboring gene prolylcarboxypeptidase (angiotensinase C) Neighboring gene predicted gene, 31663

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA damage-induced apoptosis suppressor protein
    Names
    nitric oxide-inducible gene protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080995.2NP_001074464.1  DNA damage-induced apoptosis suppressor protein

      See identical proteins and their annotated locations for NP_001074464.1

      Status: VALIDATED

      Source sequence(s)
      AC158138
      Consensus CDS
      CCDS40022.1
      UniProtKB/Swiss-Prot
      A2T1E9, Q6NZG4
      UniProtKB/TrEMBL
      E9QLR9
      Conserved Domains (1) summary
      cl09930
      Location:8102
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
    2. NM_001355126.1NP_001342055.1  DNA damage-induced apoptosis suppressor protein

      Status: VALIDATED

      Source sequence(s)
      AC158138
      Consensus CDS
      CCDS40022.1
      UniProtKB/Swiss-Prot
      A2T1E9, Q6NZG4
      UniProtKB/TrEMBL
      E9QLR9
      Related
      ENSMUSP00000032877.10, ENSMUST00000032877.11
      Conserved Domains (1) summary
      cl09930
      Location:8102
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
    3. NM_001368705.1NP_001355634.1  DNA damage-induced apoptosis suppressor protein

      Status: VALIDATED

      Source sequence(s)
      AC158138
      Consensus CDS
      CCDS40022.1
      UniProtKB/Swiss-Prot
      A2T1E9, Q6NZG4
      UniProtKB/TrEMBL
      E9QLR9
      Conserved Domains (1) summary
      cl09930
      Location:8102
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      92506734..92523455 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_028729.1: Suppressed sequence

      Description
      NM_028729.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.