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    Tln2 talin 2 [ Mus musculus (house mouse) ]

    Gene ID: 70549, updated on 3-Dec-2024

    Summary

    Official Symbol
    Tln2provided by MGI
    Official Full Name
    talin 2provided by MGI
    Primary source
    MGI:MGI:1917799
    See related
    Ensembl:ENSMUSG00000052698 AllianceGenome:MGI:1917799
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0320; 5730421P04Rik
    Summary
    Predicted to enable integrin binding activity. Predicted to be involved in cell-cell adhesion and presynaptic actin cytoskeleton organization. Located in fascia adherens and synapse. Is expressed in several structures, including brain; ganglia; heart; submandibular gland; and trigeminal nerve. Orthologous to human TLN2 (talin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in kidney adult (RPKM 19.0), testis adult (RPKM 15.4) and 20 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tln2 in Genome Data Viewer
    Location:
    9 C; 9 36.39 cM
    Exon count:
    67
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (67124371..67541357, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (67217085..67634045, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24488 Neighboring gene predicted gene 10646 Neighboring gene predicted gene, 22145 Neighboring gene STARR-seq mESC enhancer starr_24489 Neighboring gene predicted gene, 19299 Neighboring gene predicted gene, 40529 Neighboring gene STARR-seq mESC enhancer starr_24490 Neighboring gene STARR-seq mESC enhancer starr_24492 Neighboring gene microRNA 190a Neighboring gene STARR-seq mESC enhancer starr_24494 Neighboring gene STARR-seq mESC enhancer starr_24495 Neighboring gene STARR-seq mESC enhancer starr_24496 Neighboring gene STARR-seq mESC enhancer starr_24498 Neighboring gene predicted gene, 30936 Neighboring gene C2 calcium-dependent domain containing 4B Neighboring gene microRNA 7241

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC100340

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in presynaptic actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fascia adherens IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081242.3NP_001074711.2  talin-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107740, AC173343, CT573422
      Consensus CDS
      CCDS52849.1
      UniProtKB/TrEMBL
      B2RY15, E9PUM4
      Related
      ENSMUSP00000039633.8, ENSMUST00000040025.14
      Conserved Domains (10) summary
      cd12150
      Location:16561827
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:90316
      B41; Band 4.1 homologues
      smart00307
      Location:23372532
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:206316
      FERM_M; FERM central domain
      pfam08913
      Location:18501974
      VBS; Vinculin Binding Site
      pfam09141
      Location:494655
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92188
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:706832
      I_LWEQ; I/LWEQ domain
    2. NM_001408298.1NP_001395227.1  talin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC107740, AC173343, CT573422
      UniProtKB/TrEMBL
      B2RY15
    3. NM_001408299.1NP_001395228.1  talin-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC107740
      UniProtKB/TrEMBL
      Q9CS79
    4. NM_001408300.1NP_001395229.1  talin-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC107740
      UniProtKB/TrEMBL
      Q6PB69
    5. NM_001408301.1NP_001395230.1  talin-2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC107740
    6. NM_027458.2NP_081734.1  talin-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC107740
      UniProtKB/TrEMBL
      A0A1L1SRI1, Q8CDM9
      Related
      ENSMUSP00000149284.2, ENSMUST00000215267.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      67124371..67541357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511434.5XP_006511497.1  talin-2 isoform X1

      See identical proteins and their annotated locations for XP_006511497.1

      UniProtKB/TrEMBL
      B2RY15
      Conserved Domains (9) summary
      cd12150
      Location:16581829
      talin-RS; rod-segment of the talin C-terminal domain
      smart00307
      Location:23392549
      ILWEQ; I/LWEQ domain
      cd10569
      Location:314405
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:18521976
      VBS; Vinculin Binding Site
      cd17172
      Location:689
      FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
      cd17174
      Location:90201
      FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
      pfam00373
      Location:211318
      FERM_M; FERM central domain
      pfam09141
      Location:496657
      Talin_middle; Talin, middle domain
      cl19756
      Location:691767
      I_LWEQ; I/LWEQ domain
    2. XM_011242812.4XP_011241114.1  talin-2 isoform X3

      UniProtKB/TrEMBL
      B2RY15
      Conserved Domains (9) summary
      cd12150
      Location:16581829
      talin-RS; rod-segment of the talin C-terminal domain
      smart00307
      Location:22992509
      ILWEQ; I/LWEQ domain
      cd10569
      Location:314405
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:18521936
      VBS; Vinculin Binding Site
      cd17172
      Location:689
      FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
      cd17174
      Location:90201
      FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
      pfam00373
      Location:211318
      FERM_M; FERM central domain
      pfam09141
      Location:496657
      Talin_middle; Talin, middle domain
      cl19756
      Location:691767
      I_LWEQ; I/LWEQ domain
    3. XM_036155280.1XP_036011173.1  talin-2 isoform X2

      UniProtKB/TrEMBL
      A0A1L1SQ51, B2RY15
      Related
      ENSMUSP00000148901.2, ENSMUST00000215784.2
      Conserved Domains (9) summary
      cd12150
      Location:16581829
      talin-RS; rod-segment of the talin C-terminal domain
      smart00307
      Location:23392534
      ILWEQ; I/LWEQ domain
      cd10569
      Location:314405
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:18521976
      VBS; Vinculin Binding Site
      cd17172
      Location:689
      FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
      cd17174
      Location:90201
      FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
      pfam00373
      Location:211318
      FERM_M; FERM central domain
      pfam09141
      Location:496657
      Talin_middle; Talin, middle domain
      cl19756
      Location:691767
      I_LWEQ; I/LWEQ domain
    4. XM_036155278.1XP_036011171.1  talin-2 isoform X1

      UniProtKB/TrEMBL
      B2RY15
      Conserved Domains (9) summary
      cd12150
      Location:16581829
      talin-RS; rod-segment of the talin C-terminal domain
      smart00307
      Location:23392549
      ILWEQ; I/LWEQ domain
      cd10569
      Location:314405
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:18521976
      VBS; Vinculin Binding Site
      cd17172
      Location:689
      FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
      cd17174
      Location:90201
      FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
      pfam00373
      Location:211318
      FERM_M; FERM central domain
      pfam09141
      Location:496657
      Talin_middle; Talin, middle domain
      cl19756
      Location:691767
      I_LWEQ; I/LWEQ domain
    5. XM_006511433.3XP_006511496.1  talin-2 isoform X1

      See identical proteins and their annotated locations for XP_006511496.1

      UniProtKB/TrEMBL
      B2RY15
      Conserved Domains (9) summary
      cd12150
      Location:16581829
      talin-RS; rod-segment of the talin C-terminal domain
      smart00307
      Location:23392549
      ILWEQ; I/LWEQ domain
      cd10569
      Location:314405
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:18521976
      VBS; Vinculin Binding Site
      cd17172
      Location:689
      FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
      cd17174
      Location:90201
      FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
      pfam00373
      Location:211318
      FERM_M; FERM central domain
      pfam09141
      Location:496657
      Talin_middle; Talin, middle domain
      cl19756
      Location:691767
      I_LWEQ; I/LWEQ domain
    6. XM_036155279.1XP_036011172.1  talin-2 isoform X1

      UniProtKB/TrEMBL
      B2RY15
      Conserved Domains (9) summary
      cd12150
      Location:16581829
      talin-RS; rod-segment of the talin C-terminal domain
      smart00307
      Location:23392549
      ILWEQ; I/LWEQ domain
      cd10569
      Location:314405
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:18521976
      VBS; Vinculin Binding Site
      cd17172
      Location:689
      FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
      cd17174
      Location:90201
      FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
      pfam00373
      Location:211318
      FERM_M; FERM central domain
      pfam09141
      Location:496657
      Talin_middle; Talin, middle domain
      cl19756
      Location:691767
      I_LWEQ; I/LWEQ domain
    7. XM_011242811.3XP_011241113.1  talin-2 isoform X1

      See identical proteins and their annotated locations for XP_011241113.1

      UniProtKB/TrEMBL
      B2RY15
      Conserved Domains (9) summary
      cd12150
      Location:16581829
      talin-RS; rod-segment of the talin C-terminal domain
      smart00307
      Location:23392549
      ILWEQ; I/LWEQ domain
      cd10569
      Location:314405
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:18521976
      VBS; Vinculin Binding Site
      cd17172
      Location:689
      FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
      cd17174
      Location:90201
      FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
      pfam00373
      Location:211318
      FERM_M; FERM central domain
      pfam09141
      Location:496657
      Talin_middle; Talin, middle domain
      cl19756
      Location:691767
      I_LWEQ; I/LWEQ domain
    8. XM_030244583.1XP_030100443.1  talin-2 isoform X1

      UniProtKB/TrEMBL
      B2RY15
      Conserved Domains (9) summary
      cd12150
      Location:16581829
      talin-RS; rod-segment of the talin C-terminal domain
      smart00307
      Location:23392549
      ILWEQ; I/LWEQ domain
      cd10569
      Location:314405
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:18521976
      VBS; Vinculin Binding Site
      cd17172
      Location:689
      FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
      cd17174
      Location:90201
      FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
      pfam00373
      Location:211318
      FERM_M; FERM central domain
      pfam09141
      Location:496657
      Talin_middle; Talin, middle domain
      cl19756
      Location:691767
      I_LWEQ; I/LWEQ domain
    9. XM_006511441.3XP_006511504.1  talin-2 isoform X5

      UniProtKB/TrEMBL
      A0A1L1SRI1
      Related
      ENSMUSP00000149474.2, ENSMUST00000217550.2
      Conserved Domains (3) summary
      cd12150
      Location:504675
      talin-RS; rod-segment of the talin C-terminal domain
      pfam08913
      Location:698822
      VBS; Vinculin Binding Site
      cl19756
      Location:11851395
      I_LWEQ; I/LWEQ domain