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    Tbc1d2b TBC1 domain family, member 2B [ Mus musculus (house mouse) ]

    Gene ID: 67016, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tbc1d2bprovided by MGI
    Official Full Name
    TBC1 domain family, member 2Bprovided by MGI
    Primary source
    MGI:MGI:1914266
    See related
    Ensembl:ENSMUSG00000037410 AllianceGenome:MGI:1914266
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1055; 1810061M12Rik
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in endocytosis. Predicted to be located in cytosol and early endosome. Is expressed in genitourinary system. Orthologous to human TBC1D2B (TBC1 domain family member 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 19.4), mammary gland adult (RPKM 17.7) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tbc1d2b in Genome Data Viewer
    Location:
    9 E3.1; 9 47.48 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (90084100..90152861, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (90202047..90270772, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9030 Neighboring gene STARR-seq mESC enhancer starr_24885 Neighboring gene nuclear encoded tRNA lysine 18 (anticodon CTT) Neighboring gene RIKEN cDNA 9430062P05 gene Neighboring gene STARR-seq mESC enhancer starr_24886 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 7 Neighboring gene STARR-positive B cell enhancer ABC_E8860 Neighboring gene predicted gene 16200 Neighboring gene predicted gene, 30849 Neighboring gene predicted gene, 22717 Neighboring gene predicted gene, 22866

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    TBC1 domain family member 2B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413795.1NP_001400724.1  TBC1 domain family member 2B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140392, AC151735
    2. NM_194334.3NP_919315.2  TBC1 domain family member 2B isoform 1

      See identical proteins and their annotated locations for NP_919315.2

      Status: VALIDATED

      Source sequence(s)
      AC140392, AC151735
      Consensus CDS
      CCDS23401.1
      UniProtKB/Swiss-Prot
      Q2VPQ4, Q3U0J8, Q6PHN8, Q6ZPZ5
      Related
      ENSMUSP00000045413.8, ENSMUST00000041767.14
      Conserved Domains (4) summary
      cd01265
      Location:36144
      PH_TBC1D2A; TBC1 domain family member 2A pleckstrin homology (PH) domain
      pfam00169
      Location:38136
      PH; PH domain
      pfam00566
      Location:710878
      RabGAP-TBC; Rab-GTPase-TBC domain
      pfam16515
      Location:341378
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      90084100..90152861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001778980.3 RNA Sequence