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    Catsper1 cation channel, sperm associated 1 [ Mus musculus (house mouse) ]

    Gene ID: 225865, updated on 9-Dec-2024

    Summary

    Official Symbol
    Catsper1provided by MGI
    Official Full Name
    cation channel, sperm associated 1provided by MGI
    Primary source
    MGI:MGI:2179947
    See related
    Ensembl:ENSMUSG00000038498 AllianceGenome:MGI:2179947
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KSper; Catsper
    Summary
    Enables voltage-gated calcium channel activity. Acts upstream of or within several processes, including flagellated sperm motility; fusion of sperm to egg plasma membrane involved in single fertilization; and regulation of cilium beat frequency involved in ciliary motility. Located in plasma membrane and sperm principal piece. Part of CatSper complex. Is expressed in germ cell of testis; spermatid; spermatocyte; spermatozoon; and testis. Human ortholog(s) of this gene implicated in spermatogenic failure 7. Orthologous to human CATSPER1 (cation channel sperm associated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 93.8) See more
    Orthologs
    NEW
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    Genomic context

    See Catsper1 in Genome Data Viewer
    Location:
    19 A; 19 4.3 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5385643..5394309)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5335615..5344281)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene galactose-3-O-sulfotransferase 3 Neighboring gene predicted gene, 42064 Neighboring gene RNA polymerase II associated protein 2 pseudogene Neighboring gene cystatin E/M Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5366783-5366974 Neighboring gene BAF nuclear assembly factor 1 Neighboring gene eukaryotic translation initiation factor 1A domain containing

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium-activated cation channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of CatSper complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of CatSper complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm principal piece IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cation channel sperm-associated protein 1
    Names
    sperm calcium channel 1
    sperm ion channel
    sperm protein CATSPER1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139301.3NP_647462.1  cation channel sperm-associated protein 1

      See identical proteins and their annotated locations for NP_647462.1

      Status: VALIDATED

      Source sequence(s)
      AC122861
      Consensus CDS
      CCDS29456.1
      UniProtKB/Swiss-Prot
      Q4PZC3, Q4PZC4, Q4PZC5, Q4PZC6, Q4PZD2, Q91ZR5
      Related
      ENSMUSP00000045430.4, ENSMUST00000043380.5
      Conserved Domains (2) summary
      pfam00520
      Location:386581
      Ion_trans; Ion transport protein
      pfam15502
      Location:99201
      MPLKIP; M-phase-specific PLK1-interacting protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5385643..5394309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531708.2XP_006531771.1  cation channel sperm-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A494B9U9
      Related
      ENSMUSP00000157759.2, ENSMUST00000235380.2
      Conserved Domains (2) summary
      pfam00520
      Location:274502
      Ion_trans; Ion transport protein
      pfam05110
      Location:29106
      AF-4; AF-4 proto-oncoprotein
    2. XM_017318141.1XP_017173630.1  cation channel sperm-associated protein 1 isoform X2

      Conserved Domains (1) summary
      pfam00520
      Location:17171
      Ion_trans; Ion transport protein

    RNA

    1. XR_001782577.2 RNA Sequence