Glyat glycine-N-acyltransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Glyatprovided by MGI
Official Full Name: glycine-N-acyltransferaseprovided by MGI
Primary source: MGI:MGI:2147502
See related: Ensembl:ENSMUSG00000063683 AllianceGenome:MGI:2147502
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CAT; GAT; ACGNAT; A330009E03Rik
Summary: Predicted to enable glycine N-acyltransferase activity and glycine N-benzoyltransferase activity. Predicted to be involved in benzoyl-CoA metabolic process; glycine metabolic process; and monocarboxylic acid metabolic process. Located in mitochondrion. Orthologous to human GLYAT (glycine-N-acyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in kidney adult (RPKM 73.4), liver adult (RPKM 26.2) and 1 other tissue See more
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Genomic context

Location:: 19 A; 19 8.73 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (12610672..12629101)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (12633308..12651737)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mouse glycine N-acyltransferase was successfully overexpressed and purified from Escherichia coli. Benzoyl-CoA and glycine were the substrates with the highest (kcat/Km)app values.
Title: Expression, purification, and characterization of mouse glycine N-acyltransferase in Escherichia coli.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1)

General gene information

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Markers

AI315345 (e-PCR)
- UniSTS:160806

AI195249 (e-PCR)
- UniSTS:181211

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glycine N-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine N-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycine N-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glycine N-benzoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine N-benzoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glycine N-benzoyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in benzoyl-CoA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in benzoyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in monocarboxylic acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glycine N-acyltransferase

Names: AAc; acyl-CoA:glycine N-acyltransferase; aralkyl acyl-CoA N-acyltransferase; aralkyl acyl-CoA:amino acid N-acyltransferase; benzoyl-coenzyme A:glycine N-acyltransferase; glycine N-benzoyltransferase

NP_666047.1

EC 2.3.1.13

EC 2.3.1.71

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145935.3 → NP_666047.1 glycine N-acyltransferase

See identical proteins and their annotated locations for NP_666047.1

Status: VALIDATED

Source sequence(s)

AK039262

Consensus CDS

CCDS29633.1

UniProtKB/Swiss-Prot

Q05DG2, Q91XE0

Related

ENSMUSP00000043308.6, ENSMUST00000044976.12

Conserved Domains (2) summary

pfam08444
Location:207 → 295

Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region

pfam06021
Location:11 → 206

Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase