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    Pidd1 p53 induced death domain protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 57913, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pidd1provided by MGI
    Official Full Name
    p53 induced death domain protein 1provided by MGI
    Primary source
    MGI:MGI:1889507
    See related
    Ensembl:ENSMUSG00000025507 AllianceGenome:MGI:1889507
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lrdd; Pidd; 1200011D09Rik
    Summary
    Predicted to enable endopeptidase activity. Acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process and extrinsic apoptotic signaling pathway via death domain receptors. Located in cytoplasm. Is expressed in brain; liver; nose; and urinary system. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 75. Orthologous to human PIDD1 (p53-induced death domain protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in thymus adult (RPKM 13.9), liver E14.5 (RPKM 6.5) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pidd1 in Genome Data Viewer
    Location:
    7 F5; 7 86.79 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141018026..141027477, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141438113..141447565, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cell cycle exit and neuronal differentiation 1 Neighboring gene solute carrier family 25 (mitochondrial carrier, glutamate), member 22 Neighboring gene STARR-positive B cell enhancer ABC_E4986 Neighboring gene STARR-positive B cell enhancer ABC_E1097 Neighboring gene ribosomal protein lateral stalk subunit P2 Neighboring gene small nucleolar RNA, H/ACA box 52 Neighboring gene STARR-positive B cell enhancer ABC_E9305 Neighboring gene patatin-like phospholipase domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autoprocessing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein autoprocessing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of endopeptidase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    p53-induced death domain-containing protein 1
    Names
    leucine-rich and death domain containing
    leucine-rich repeat and death domain-containing protein
    p53 protein induced, with death domain
    p53-induced protein with a death domain

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360523.1NP_001347452.1  p53-induced death domain-containing protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (a).
      Source sequence(s)
      AC158224, BC145314
      Related
      ENSMUST00000131980.8
      Conserved Domains (3) summary
      cd08779
      Location:475560
      Death_PIDD; Death Domain of p53-induced protein with a death domain
      pfam10461
      Location:108140
      Peptidase_S68; Peptidase S68
      cl02517
      Location:1285
      ZU5; ZU5 domain
    2. NM_001360524.1NP_001347453.1  p53-induced death domain-containing protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (a).
      Source sequence(s)
      AC158224, BC089373
      Related
      ENSMUST00000147268.8
      Conserved Domains (3) summary
      cd08779
      Location:475560
      Death_PIDD; Death Domain of p53-induced protein with a death domain
      pfam10461
      Location:108140
      Peptidase_S68; Peptidase S68
      cl02517
      Location:1285
      ZU5; ZU5 domain
    3. NM_022654.2NP_073145.1  p53-induced death domain-containing protein 1 isoform a

      See identical proteins and their annotated locations for NP_073145.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC158224
      Consensus CDS
      CCDS22014.1
      UniProtKB/Swiss-Prot
      A6H6F4, Q9ERV7
      Related
      ENSMUSP00000026580.6, ENSMUST00000026580.12
      Conserved Domains (6) summary
      cd00116
      Location:132295
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:132154
      LRR_RI; leucine-rich repeat [structural motif]
      pfam10461
      Location:426458
      Peptidase_S68; Peptidase S68
      pfam13855
      Location:222280
      LRR_8; Leucine rich repeat
      cl02517
      Location:330403
      ZU5; ZU5 domain
      cl14633
      Location:793878
      DD; Death Domain Superfamily of protein-protein interaction domains

    RNA

    1. NR_153591.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC158224
      Related
      ENSMUST00000128703.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      141018026..141027477 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153304.1XP_036009197.1  p53-induced death domain-containing protein 1 isoform X2

      Conserved Domains (3) summary
      cd08779
      Location:475560
      Death_PIDD; Death Domain of p53-induced protein with a death domain
      pfam10461
      Location:108140
      Peptidase_S68; Peptidase S68
      cl02517
      Location:1285
      ZU5; ZU5 domain
    2. XM_011249849.4XP_011248151.1  p53-induced death domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011248151.1

      Conserved Domains (4) summary
      COG4886
      Location:126285
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:132154
      LRR_RI; leucine-rich repeat [structural motif]
      pfam10461
      Location:426458
      Peptidase_S68; Peptidase S68
      cl02517
      Location:330403
      ZU5; ZU5 domain

    RNA

    1. XR_001785592.3 RNA Sequence

    2. XR_389958.5 RNA Sequence

    3. XR_004934157.1 RNA Sequence