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    Il25 interleukin 25 [ Mus musculus (house mouse) ]

    Gene ID: 140806, updated on 9-Dec-2024

    Summary

    Official Symbol
    Il25provided by MGI
    Official Full Name
    interleukin 25provided by MGI
    Primary source
    MGI:MGI:2155888
    See related
    Ensembl:ENSMUSG00000040770 AllianceGenome:MGI:2155888
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IL-25; Il17e; IL-17e
    Summary
    Enables cytokine activity. Acts upstream of or within several processes, including eosinophil differentiation; positive regulation of transcription by RNA polymerase II; and response to nematode. Predicted to be located in extracellular space. Orthologous to human IL25 (interleukin 25). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Il25 in Genome Data Viewer
    Location:
    14 C3; 14 28.0 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55170152..55173294)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54932695..54935837)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene poly(A) binding protein, nuclear 1 Neighboring gene solute carrier family 22 (organic cation transporter), member 17 Neighboring gene embryonal Fyn-associated substrate Neighboring gene STARR-seq mESC enhancer starr_36750 Neighboring gene CKLF-like MARVEL transmembrane domain containing 5 Neighboring gene myosin, heavy polypeptide 6, cardiac muscle, alpha Neighboring gene microRNA 208a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (8)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables interleukin-17E receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    interleukin-25
    Names
    interleukin 17E

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080729.3NP_542767.1  interleukin-25 precursor

      See identical proteins and their annotated locations for NP_542767.1

      Status: VALIDATED

      Source sequence(s)
      AF458060, AI429629, BQ554452, BX517868
      Consensus CDS
      CCDS36926.1
      UniProtKB/Swiss-Prot
      Q8VHH8
      UniProtKB/TrEMBL
      Q8VHC9
      Related
      ENSMUSP00000039641.6, ENSMUST00000037863.6
      Conserved Domains (1) summary
      pfam06083
      Location:77163
      IL17; Interleukin-17

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55170152..55173294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)