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    Chmp4c charged multivesicular body protein 4C [ Mus musculus (house mouse) ]

    Gene ID: 66371, updated on 9-Dec-2024

    Summary

    Official Symbol
    Chmp4cprovided by MGI
    Official Full Name
    charged multivesicular body protein 4Cprovided by MGI
    Primary source
    MGI:MGI:1913621
    See related
    Ensembl:ENSMUSG00000027536 AllianceGenome:MGI:1913621
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Shax3; Snf7-3; 2010012P02Rik; 2210015K02Rik; 2310010I16Rik
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be involved in several processes, including proteolysis involved in protein catabolic process; regulation of cell cycle process; and vacuolar transport. Predicted to be located in several cellular components, including Flemming body; bounding membrane of organelle; and kinetochore microtubule. Predicted to be part of ESCRT III complex and nuclear pore. Predicted to be active in cytoplasmic side of plasma membrane and multivesicular body. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; lung; and lymph node. Orthologous to human CHMP4C (charged multivesicular body protein 4C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 7.1), placenta adult (RPKM 5.2) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Chmp4c in Genome Data Viewer
    Location:
    3 A1; 3 2.63 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (10432033..10456065)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (10366973..10391005)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7900 Neighboring gene STARR-positive B cell enhancer mm9_chr3:10351257-10351557 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 5 Neighboring gene STARR-seq mESC enhancer starr_06944 Neighboring gene zinc finger, AN1-type domain 1 Neighboring gene sorting nexin 16 Neighboring gene STARR-seq mESC enhancer starr_06952 Neighboring gene STARR-seq mESC enhancer starr_06953 Neighboring gene STARR-seq mESC enhancer starr_06954 Neighboring gene STARR-seq mESC enhancer starr_06955 Neighboring gene STARR-seq mESC enhancer starr_06956 Neighboring gene STARR-seq mESC enhancer starr_06957 Neighboring gene STARR-seq mESC enhancer starr_06958 Neighboring gene von Hippel-Lindau binding protein 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC144772, MGC144773

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in abscission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagosome maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in late endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in membrane fission NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in midbody abscission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in midbody abscission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic cytokinesis checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cytokinesis checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in multivesicular body assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in multivesicular body-lysosome fusion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nuclear membrane reassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleus organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in plasma membrane repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of centrosome duplication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle budding from membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle fusion with vacuole NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in viral budding from plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in viral budding via host ESCRT complex ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of ESCRT III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Flemming body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Flemming body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in amphisome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in autophagosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in multivesicular body membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    charged multivesicular body protein 4c
    Names
    Snf7 homologue associated with Alix 3
    chromatin modifying protein 4C
    chromatin-modifying protein 4c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025519.2NP_079795.1  charged multivesicular body protein 4c

      See identical proteins and their annotated locations for NP_079795.1

      Status: PROVISIONAL

      Source sequence(s)
      AC123726
      Consensus CDS
      CCDS17243.1
      UniProtKB/Swiss-Prot
      Q149R2, Q3TVD7, Q9CWH8, Q9D7F7
      UniProtKB/TrEMBL
      Q3TLQ5
      Related
      ENSMUSP00000029049.6, ENSMUST00000029049.7
      Conserved Domains (1) summary
      pfam03357
      Location:24190
      Snf7; Snf7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      10432033..10456065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)