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    Trim8 tripartite motif-containing 8 [ Mus musculus (house mouse) ]

    Gene ID: 93679, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trim8provided by MGI
    Official Full Name
    tripartite motif-containing 8provided by MGI
    Primary source
    MGI:MGI:1933302
    See related
    Ensembl:ENSMUSG00000025034 AllianceGenome:MGI:1933302
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GERP; Rnf27
    Summary
    Predicted to enable several functions, including mitogen-activated protein kinase kinase kinase binding activity; protein homodimerization activity; and transcription coactivator activity. Involved in defense response to symbiont; negative regulation of viral entry into host cell; and negative regulation of viral transcription. Acts upstream of or within positive regulation of protein localization to nucleus and stem cell population maintenance. Located in cytosol and nucleus. Is expressed in several structures, including central nervous system; female reproductive system; and urinary system. Orthologous to human TRIM8 (tripartite motif containing 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 48.9), lung adult (RPKM 41.9) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Trim8 in Genome Data Viewer
    Location:
    19 C3; 19 38.92 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46490087..46504894)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46501648..46516805)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3253 Neighboring gene ARP1 actin-related protein 1A, centractin alpha Neighboring gene STARR-positive B cell enhancer ABC_E7668 Neighboring gene STARR-positive B cell enhancer ABC_E1528 Neighboring gene SUFU negative regulator of hedgehog signaling Neighboring gene STARR-positive B cell enhancer ABC_E4288 Neighboring gene STARR-positive B cell enhancer ABC_E5708 Neighboring gene STARR-seq mESC enhancer starr_46309 Neighboring gene STARR-positive B cell enhancer ABC_E268 Neighboring gene STARR-seq mESC enhancer starr_46312 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:46592537-46592738 Neighboring gene STARR-seq mESC enhancer starr_46316 Neighboring gene ADP-ribosylation factor-like 3 Neighboring gene STARR-positive B cell enhancer ABC_E8752 Neighboring gene STARR-positive B cell enhancer mm9_chr19:46647489-46647790 Neighboring gene sideroflexin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitogen-activated protein kinase kinase kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of viral entry into host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of viral transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein K63-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in suppression of viral release by host IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in suppression of viral release by host ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM8
    Names
    RING-type E3 ubiquitin transferase TRIM8
    glioblastoma-expressed RING finger protein
    probable E3 ubiquitin-protein ligase TRIM8
    ring finger protein 27
    tripartite motif protein 8
    tripartite motif-containing protein 8
    NP_001411955.1
    NP_444330.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001425026.1NP_001411955.1  E3 ubiquitin-protein ligase TRIM8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC156982
    2. NM_053100.2NP_444330.2  E3 ubiquitin-protein ligase TRIM8 isoform 1

      See identical proteins and their annotated locations for NP_444330.2

      Status: VALIDATED

      Source sequence(s)
      BC082298, BM944255
      Consensus CDS
      CCDS38009.1
      UniProtKB/Swiss-Prot
      Q3U2G3, Q8C508, Q8C700, Q8CGI2, Q99PJ2, Q99PQ4
      Related
      ENSMUSP00000026008.8, ENSMUST00000026008.9
      Conserved Domains (3) summary
      pfam00643
      Location:140182
      zf-B_box; B-box zinc finger
      cl17238
      Location:1555
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl23765
      Location:189257
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      46490087..46504894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)