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    Usf2 upstream transcription factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 22282, updated on 3-Dec-2024

    Summary

    Official Symbol
    Usf2provided by MGI
    Official Full Name
    upstream transcription factor 2provided by MGI
    Primary source
    MGI:MGI:99961
    See related
    Ensembl:ENSMUSG00000058239 AllianceGenome:MGI:99961
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Usf-2; bHLHb12
    Summary
    Enables DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in glucose mediated signaling pathway; lipid homeostasis; and positive regulation of transcription from RNA polymerase II promoter by glucose. Acts upstream of or within lactation; positive regulation of DNA-templated transcription; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and sensory organ. Orthologous to human USF2 (upstream transcription factor 2, c-fos interacting). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 66.5), ovary adult (RPKM 53.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Usf2 in Genome Data Viewer
    Location:
    7 B1; 7 19.27 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30645421..30656288, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30945248..30956951, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene upstream transcription factor 2, pseudogene 1 Neighboring gene hepcidin antimicrobial peptide Neighboring gene lipolysis stimulated lipoprotein receptor Neighboring gene STARR-positive B cell enhancer ABC_E10435 Neighboring gene family with sequence similarity 187, member B Neighboring gene olfactory receptor 1359 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC91056

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables bHLH transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables bHLH transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    upstream stimulatory factor 2
    Names
    major late transcription factor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001421807.1NP_001408736.1  upstream stimulatory factor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC149055
      UniProtKB/TrEMBL
      F6PWU6, F8WI12
      Related
      ENSMUSP00000125520.3, ENSMUST00000162228.9
    2. NM_001421808.1NP_001408737.1  upstream stimulatory factor 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC149055
      Related
      ENSMUSP00000132021.2, ENSMUST00000108119.10
    3. NM_001421809.1NP_001408738.1  upstream stimulatory factor 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC149055
    4. NM_011680.3NP_035810.1  upstream stimulatory factor 2 isoform 1

      See identical proteins and their annotated locations for NP_035810.1

      Status: VALIDATED

      Source sequence(s)
      AC149055
      Consensus CDS
      CCDS21118.1
      UniProtKB/Swiss-Prot
      Q3UIL2, Q64705, Q8VE59
      UniProtKB/TrEMBL
      F6PWU6
      Related
      ENSMUSP00000132256.2, ENSMUST00000058860.14
      Conserved Domains (2) summary
      cd18923
      Location:229308
      bHLHzip_USF2; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) and similar proteins
      pfam06005
      Location:290334
      ZapB; Cell division protein ZapB

    RNA

    1. NR_185327.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC149055
    2. NR_185328.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC149055
    3. NR_185329.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC149055
    4. NR_185330.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC149055
    5. NR_185331.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC149055

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      30645421..30656288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)