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    Itm2b integral membrane protein 2B [ Mus musculus (house mouse) ]

    Gene ID: 16432, updated on 9-Dec-2024

    Summary

    Official Symbol
    Itm2bprovided by MGI
    Official Full Name
    integral membrane protein 2Bprovided by MGI
    Primary source
    MGI:MGI:1309517
    See related
    Ensembl:ENSMUSG00000022108 AllianceGenome:MGI:1309517
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bri; Bri2; E25BMM; imBRI2; Bricd2b; D14Sel6
    Summary
    Enables ATP binding activity. Predicted to be involved in negative regulation of amyloid precursor protein biosynthetic process. Predicted to be located in Golgi-associated vesicle membrane and extracellular space. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in central nervous system; pancreas epithelium; and retina. Used to study cerebral amyloid angiopathy. Human ortholog(s) of this gene implicated in ITM2B-related cerebral amyloid angiopathy 1 and ITM2B-related cerebral amyloid angiopathy 2. Orthologous to human ITM2B (integral membrane protein 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in genital fat pad adult (RPKM 2218.4), kidney adult (RPKM 608.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Itm2b in Genome Data Viewer
    Location:
    14 D3; 14 38.88 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (73599666..73622729, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (73362226..73385289, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RB transcriptional corepressor 1 Neighboring gene STARR-seq mESC enhancer starr_37112 Neighboring gene microRNA 687 Neighboring gene VISTA enhancer mm1341 Neighboring gene STARR-seq mESC enhancer starr_37114 Neighboring gene lysophosphatidic acid receptor 6 Neighboring gene STARR-seq mESC enhancer starr_37116 Neighboring gene STARR-positive B cell enhancer ABC_E9900 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:73788957-73789140 Neighboring gene STARR-positive B cell enhancer ABC_E7335 Neighboring gene STARR-seq mESC enhancer starr_37118 Neighboring gene STARR-seq mESC enhancer starr_37119 Neighboring gene predicted gene, 35450 Neighboring gene predicted gene 4266

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables amyloid-beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi-associated vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi-associated vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in organelle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    integral membrane protein 2B
    Names
    immature BRI2
    integral membrane protein 2B (E25B protein)
    transmembrane protein BRI

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008410.3NP_032436.1  integral membrane protein 2B precursor

      See identical proteins and their annotated locations for NP_032436.1

      Status: VALIDATED

      Source sequence(s)
      AC154718
      Consensus CDS
      CCDS27269.1
      UniProtKB/Swiss-Prot
      O89051, Q545S7
      UniProtKB/TrEMBL
      Q3TVJ0, Q3UCT9
      Related
      ENSMUSP00000022704.8, ENSMUST00000022704.9
      Conserved Domains (1) summary
      smart01039
      Location:137231
      BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      73599666..73622729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)