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    Amn amnionless [ Mus musculus (house mouse) ]

    Gene ID: 93835, updated on 9-Dec-2024

    Summary

    Official Symbol
    Amnprovided by MGI
    Official Full Name
    amnionlessprovided by MGI
    Primary source
    MGI:MGI:1934943
    See related
    Ensembl:ENSMUSG00000021278 AllianceGenome:MGI:1934943
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a type I transmembrane protein. The encoded protein is an essential component of the cubulin receptor complex which is thought to play a role in coordinating growth and patterning of the embryo. This protein is thought to modulate a bone morphogenetic protein (BMP) signaling pathway. A homoygous mutation in the mouse gene results in the lack of an amnion in embryos. Mutations in the human gene are associated with Megaloblastic Anemia-1. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in duodenum adult (RPKM 275.2), small intestine adult (RPKM 230.3) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Amn in Genome Data Viewer
    Location:
    12 F1; 12 60.94 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111237530..111242860)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111271096..111276426)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:112310033-112310280 Neighboring gene REST corepressor 1 Neighboring gene STARR-positive B cell enhancer ABC_E7184 Neighboring gene DNA repair protein SWI5 homolog pseudogene Neighboring gene VISTA enhancer mm3 Neighboring gene RIKEN cDNA 4930595D18 gene Neighboring gene STARR-positive B cell enhancer mm9_chr12:112398161-112398462 Neighboring gene STARR-positive B cell enhancer ABC_E7186 Neighboring gene TNF receptor-associated factor 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:112477093-112477276 Neighboring gene RIKEN cDNA A230087F16 gene Neighboring gene predicted gene, 51960 Neighboring gene CDC42 binding protein kinase beta Neighboring gene LBH domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Clone Names

    • 5033428N14Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cargo receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cobalamin metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cobalamin transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in receptor-mediated endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in receptor-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within renal protein absorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in brush border membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microvillus membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein amnionless
    Names
    type I transmembrane protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033603.3NP_291081.2  protein amnionless precursor

      See identical proteins and their annotated locations for NP_291081.2

      Status: REVIEWED

      Source sequence(s)
      AC127580, BB873437, BC087954
      Consensus CDS
      CCDS36564.1
      UniProtKB/Swiss-Prot
      Q5I0U1, Q99JB7, Q99MP9
      Related
      ENSMUSP00000021707.7, ENSMUST00000021707.8
      Conserved Domains (1) summary
      pfam14828
      Location:21451
      Amnionless

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      111237530..111242860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)